P52787 · IF_MOUSE
- ProteinCobalamin binding intrinsic factor
- GeneCblif
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids417 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 171 | cob(II)alamin (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 222 | cob(II)alamin (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 270 | cob(II)alamin (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 365-370 | cob(II)alamin (UniProtKB | ChEBI) | ||||
Sequence: SWGLIV | ||||||
Binding site | 386-395 | cob(II)alamin (UniProtKB | ChEBI) | ||||
Sequence: WEFLSGKTPL |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | endosome | |
Cellular Component | extracellular space | |
Cellular Component | microvillus | |
Molecular Function | cargo receptor ligand activity | |
Molecular Function | cobalamin binding | |
Biological Process | cobalamin transport | |
Biological Process | cobalt ion transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCobalamin binding intrinsic factor
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP52787
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MAWLTLYLLSVLWAVAGT | ||||||
Chain | PRO_0000005559 | 19-417 | Cobalamin binding intrinsic factor | |||
Sequence: STRAQSSCSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGKTPLDEGVAYYIPFNHEHITANFTQY | ||||||
Disulfide bond | 26↔246 | |||||
Sequence: CSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDC | ||||||
Disulfide bond | 103↔288 | |||||
Sequence: CRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTC | ||||||
Disulfide bond | 143↔182 | |||||
Sequence: CQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTC | ||||||
Modified residue | 191 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 311 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 330 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 413 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length417
- Mass (Da)45,497
- Last updated2009-03-03 v2
- ChecksumBF38663EFC90F34A
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 86 | in Ref. 1; AAA37881/AAA37882 | ||||
Sequence: D → N | ||||||
Sequence conflict | 156 | in Ref. 1; AAA37881/AAA37882 | ||||
Sequence: R → A | ||||||
Sequence conflict | 327 | in Ref. 1; AAA37881/AAA37882 | ||||
Sequence: L → P |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L24192 EMBL· GenBank· DDBJ | AAA37881.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L24191 EMBL· GenBank· DDBJ | AAA37882.1 EMBL· GenBank· DDBJ | mRNA | ||
AK078933 EMBL· GenBank· DDBJ | BAC37468.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466534 EMBL· GenBank· DDBJ | EDL41439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC118519 EMBL· GenBank· DDBJ | AAI18520.1 EMBL· GenBank· DDBJ | mRNA |