P52787 · IF_MOUSE

  • Protein
    Cobalamin binding intrinsic factor
  • Gene
    Cblif
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).

Features

Showing features for binding site.

141750100150200250300350400
TypeIDPosition(s)Description
Binding site171cob(II)alamin (UniProtKB | ChEBI)
Binding site222cob(II)alamin (UniProtKB | ChEBI)
Binding site270cob(II)alamin (UniProtKB | ChEBI)
Binding site365-370cob(II)alamin (UniProtKB | ChEBI)
Binding site386-395cob(II)alamin (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentendosome
Cellular Componentextracellular space
Cellular Componentmicrovillus
Molecular Functioncargo receptor ligand activity
Molecular Functioncobalamin binding
Biological Processcobalamin transport
Biological Processcobalt ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cobalamin binding intrinsic factor
  • Alternative names
    • Gastric intrinsic factor
    • Intrinsic factor (IF; INF)

Gene names

    • Name
      Cblif
    • Synonyms
      Gif

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P52787
  • Secondary accessions
    • Q8C5C1

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000000555919-417Cobalamin binding intrinsic factor
Disulfide bond26↔246
Disulfide bond103↔288
Disulfide bond143↔182
Modified residue191Phosphoserine
Glycosylation311N-linked (GlcNAc...) asparagine
Glycosylation330N-linked (GlcNAc...) asparagine
Glycosylation413N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Gastric mucosa.

Gene expression databases

Interaction

Subunit

Interacts with CUBN (via CUB domains).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    417
  • Mass (Da)
    45,497
  • Last updated
    2009-03-03 v2
  • Checksum
    BF38663EFC90F34A
MAWLTLYLLSVLWAVAGTSTRAQSSCSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGKTPLDEGVAYYIPFNHEHITANFTQY

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict86in Ref. 1; AAA37881/AAA37882
Sequence conflict156in Ref. 1; AAA37881/AAA37882
Sequence conflict327in Ref. 1; AAA37881/AAA37882

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L24192
EMBL· GenBank· DDBJ
AAA37881.1
EMBL· GenBank· DDBJ
Genomic DNA
L24191
EMBL· GenBank· DDBJ
AAA37882.1
EMBL· GenBank· DDBJ
mRNA
AK078933
EMBL· GenBank· DDBJ
BAC37468.1
EMBL· GenBank· DDBJ
mRNA
CH466534
EMBL· GenBank· DDBJ
EDL41439.1
EMBL· GenBank· DDBJ
Genomic DNA
BC118519
EMBL· GenBank· DDBJ
AAI18520.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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