Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.Kawamura M., McVicar D.W., Johnston J.A., Blake T.B., Chen Y.-Q., Lal B.K., Lloyd A.R., Kelvin D.J., Staples J.E.[...], O'Shea J.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 91:6374-6378 (1994)Cited in11Mapped to5
A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells.Lai K.S., Jin Y., Graham D.K., Witthuhn B.A., Ihle J.N., Liu E.T.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 2)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 270:25028-25036 (1995)Cited in11
Genomic sequence, organization, and chromosomal localization of human JAK3.Riedy M.C., Dutra A.S., Blake T.B., Modi W., Lal B.K., Davis J., Bosse A., O'Shea J.J., Johnston J.A.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenomics 37:57-61 (1996)Cited in1
No title available.SeattleSNPs variation discovery resourceCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-132 AND ILE-722CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (MAY-2002)Cited in5
The DNA sequence and biology of human chromosome 19.Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O.[...], Lucas S.M.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 428:529-535 (2004)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JUL-2005)Cited in99+99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)TissueBloodCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells.Verbsky J.W., Bach E.A., Fang Y.F., Yang L., Randolph D.A., Fields L.E.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 36-191CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:13976-13980 (1996)Cited in1
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.Johnston J.A., Kawamura M., Kirken R.A., Chen Y.Q., Blake T.B., Shibuya K., Ortaldo J.R., McVicar D.W., O'Shea J.J.View abstractCited forFUNCTION IN IL2 SIGNALING PATHWAYCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 370:151-153 (1994)Cited in1Mapped to13
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase.Sharfe N., Dadi H.K., Roifman C.M.View abstractCited forFUNCTION IN IL7 SIGNALING PATHWAYCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 86:2077-2085 (1995)Cited in1
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.Musso T., Johnston J.A., Linnekin D., Varesio L., Rowe T.K., O'Shea J.J., McVicar D.W.View abstractCited forTISSUE SPECIFICITYCategoriesExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Exp. Med. 181:1425-1431 (1995)Cited in1
STAM2, a new member of the STAM family, binding to the Janus kinases.Endo K., Takeshita T., Kasai H., Sasaki Y., Tanaka N., Asao H., Kikuchi K., Yamada M., Chenb M.[...], Sugamura K.View abstractCited forINTERACTION WITH STAM2TissueFetal brainCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFEBS Lett. 477:55-61 (2000)Cited in3
IL-2 receptor signaling through the Shb adapter protein in T and NK cells.Lindholm C.K.View abstractCited forINTERACTION WITH SHBCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 296:929-936 (2002)Cited in5Mapped to8
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.Simoncic P.D., Lee-Loy A., Barber D.L., Tremblay M.L., McGlade C.J.View abstractCited forFUNCTION IN CYTOKINE SIGNALING, PHOSPHORYLATION, DEPHOSPHORYLATION AT TYR-980 AND TYR-981 BY PTPN2CategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 12:446-453 (2002)Cited in4Mapped to3
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.Saharinen P., Silvennoinen O.View abstractCited forDOMAINCategoriesFamily & DomainsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 277:47954-47963 (2002)Cited in1Mapped to18
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.Kurzer J.H., Argetsinger L.S., Zhou Y.J., Kouadio J.L., O'Shea J.J., Carter-Su C.View abstractCited forPHOSPHORYLATION AT TYR-785, MUTAGENESIS OF TYR-785CategoriesPTM / Processing, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 24:4557-4570 (2004)Cited in2Mapped to7
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Biotechnol. 23:94-101 (2005)Cited in99+99+Mapped to4
Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.Cheng H., Ross J.A., Frost J.A., Kirken R.A.View abstractCited forPHOSPHORYLATION AT TYR-904 AND TYR-939, MUTAGENESIS OF LYS-855; TYR-904 AND TYR-939CategoriesPTM / Processing, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 28:2271-2282 (2008)Cited in1Mapped to11
Janus kinases in immune cell signaling.Ghoreschi K., Laurence A., O'Shea J.J.View abstractCited forREVIEW ON FUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCImmunol. Rev. 228:273-287 (2009)Cited in2
Large-scale proteomics analysis of the human kinome.Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Proteomics 8:1751-1764 (2009)Cited in99+99+
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueLeukemic T-cellCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Signal. 2:RA46-RA46 (2009)Cited in99+99+
IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis.Malamut G., El Machhour R., Montcuquet N., Martin-Lanneree S., Dusanter-Fourt I., Verkarre V., Mention J.J., Rahmi G., Kiyono H.[...], Meresse B.View abstractCited forFUNCTION IN IL15 SIGNALING PATHWAYCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Clin. Invest. 120:2131-2143 (2010)Cited in1
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.Boggon T.J., Li Y., Manley P.W., Eck M.J.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 814-1103 IN COMPLEX WITH STAUROSPORINE ANALOG AFN941, PHOSPHORYLATION AT TYR-980 AND TYR-981CategoriesPTM / Processing, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 106:996-1002 (2005)Cited in1Mapped to6
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).Macchi P., Villa A., Giliani S., Sacco M.G., Frattini A., Porta F., Ugazio A.G., Johnston J.A., Candotti F.[...], Notarangelo L.D.View abstractCited forVARIANT T(-)B(+)NK(-) SCID CYS-100CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 377:65-68 (1995)Cited in1Mapped to6
Structural and functional basis for JAK3-deficient severe combined immunodeficiency.Candotti F., Oakes S.A., Johnston J.A., Giliani S., Schumacher R.F., Mella P., Fiorini M., Ugazio A.G., Badolato R.[...], Villa A.View abstractCited forVARIANTS T(-)B(+)NK(-) SCID GLY-481; 586-LEU--MET-592 DEL AND ARG-759CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 90:3996-4003 (1997)Cited in1