P52106 · CSGD_ECOLI

  • Protein
    CsgBAC operon transcriptional regulatory protein
  • Gene
    csgD
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up-regulates 10 genes and down-regulates 14 others.

Features

Showing features for dna binding.

121620406080100120140160180200
TypeIDPosition(s)Description
DNA binding173-192H-T-H motif

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentprotein-DNA complex
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular FunctionDNA-binding transcription activator activity
Molecular FunctionDNA-binding transcription repressor activity
Molecular Functionidentical protein binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processpositive regulation of DNA-templated transcription initiation
Biological Processregulation of single-species biofilm formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CsgBAC operon transcriptional regulatory protein

Gene names

    • Name
      csgD
    • Ordered locus names
      b1040, JW1023

Organism names

  • Taxonomic identifier
  • Strains
    • K12 / MC4100 / ATCC 35695 / DSM 6574
    • K12 / W3110 / ATCC 27325 / DSM 5911
    • K12 / MG1655 / ATCC 47076
    • O78
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    P52106

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein
Note: In experiments done with low-level constitutively expressed protein.

Keywords

Phenotypes & Variants

Disruption phenotype

No curli production.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001841431-216CsgBAC operon transcriptional regulatory protein

Proteomic databases

Expression

Induction

Regulation is very complex. Strongly induced at 28 degrees Celsius (at protein level), transcription regulation requires c-di-GMP, although the mechanism is currently unknown. c-di-GMP levels are stimulated by the diguanylate cyclase DgcM and repressed by the c-di-GMP phosphodiesterase PdeR (YciR) (PubMed:17010156).
Transcription directly repressed by MqsA, and indirectly repressed by MqsA via MqsA's repression of rpoS (PubMed:24212724).

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P52106csgD P521063EBI-555538, EBI-555538

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain149-214HTH luxR-type

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    24,935
  • Last updated
    1996-10-01 v1
  • MD5 Checksum
    5E25048121E1C8E85602A729B9DC269A
MFNEVHSIHGHTLLLITKSSLQATALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYSMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X90754
EMBL· GenBank· DDBJ
CAA62280.1
EMBL· GenBank· DDBJ
Genomic DNA
U00096
EMBL· GenBank· DDBJ
AAC74124.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009048
EMBL· GenBank· DDBJ
BAA35830.1
EMBL· GenBank· DDBJ
Genomic DNA
AH007429
EMBL· GenBank· DDBJ
AAD16025.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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