P51996 · YPT32_YEAST

Function

function

Required for protein transport through the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Mediates the proper polarized localization of SEC2, a GEF for SEC4, but does not alter the exchange activity of SEC2 on SEC4. Plays a role in autophagy.

Miscellaneous

Present with 4298 molecules/cell in log phase SD medium.

Activity regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the guanine nucleotide-exchange factor (GEF) TRAPP complex, and inactivated by GTPase-activating protein (GAP) GYP3.

Features

Showing features for binding site.

122220406080100120140160180200220
TypeIDPosition(s)Description
Binding site20-27GTP (UniProtKB | ChEBI)
Binding site68-72GTP (UniProtKB | ChEBI)
Binding site126-129GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcellular bud neck
Cellular Componentcytosol
Cellular Componentendosome
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentrecycling endosome
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processautophagy
Biological Processearly endosome to Golgi transport
Biological Processexocytosis
Biological Processprotein transport
Biological Processvesicle-mediated transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP-binding protein YPT32/YPT11
  • Alternative names
    • Rab GTPase YPT32

Gene names

    • Name
      YPT32
    • Synonyms
      YPT11
    • Ordered locus names
      YGL210W

Organism names

Accessions

  • Primary accession
    P51996
  • Secondary accessions
    • D6VTU5

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis27Binds preferentially GDP.
Mutagenesis49Cold sensitive.
Mutagenesis72Reduces GTPase activity.
Mutagenesis126Blocks nucleotide binding.
Mutagenesis141Loss of function at 37 degrees Celsius.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, lipidation.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00001213242-222GTP-binding protein YPT32/YPT11
Lipidation221S-geranylgeranyl cysteine
Lipidation222S-geranylgeranyl cysteine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with YIF1, YIP3, YIP4 and YIP5. Interacts with the GEF SEC2. Interacts with TRS130.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for motif, compositional bias, region.

TypeIDPosition(s)Description
Motif42-50Effector region
Compositional bias186-202Polar residues
Region186-222Disordered

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    222
  • Mass (Da)
    24,520
  • Last updated
    2007-01-23 v3
  • Checksum
    621217A296161964
MSNEDYGYDYDYLFKIVLIGDSGVGKSNLLSRFTTDEFNIESKSTIGVEFATRTIEVENKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYENCNHWLTELRENADDNVAVGLIGNKSDLAHLRAVPTDEAKNFAMENQMLFTETSALNSDNVDKAFRELIVAIFQMVSKHQVDLSGSGTNNMGSNGAPKGPTISLTPAPKEDKKKKSSNCC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias186-202Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X72834
EMBL· GenBank· DDBJ
CAA51355.1
EMBL· GenBank· DDBJ
Genomic DNA
U33754
EMBL· GenBank· DDBJ
AAC49495.1
EMBL· GenBank· DDBJ
Genomic DNA
Z72732
EMBL· GenBank· DDBJ
CAA96926.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558506
EMBL· GenBank· DDBJ
AAS56832.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006941
EMBL· GenBank· DDBJ
DAA07906.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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