Presynaptic Galphao (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans.
Mutations in tra-1 and goa-1 decouple behavioural patterns from the number of X chromosomes. TRA-1 binds to a conserved binding site located in the goa-1 coding region and downregulates goa-1 expression in hermaphrodites particularly during embryogenesis when neuronal development largely occurs.
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