P51827 · AFF3_MOUSE
- ProteinAF4/FMR2 family member 3
- GeneAff3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1254 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Putative transcription activator that may function in lymphoid development and oncogenesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nuclear body | |
Cellular Component | nucleus | |
Cellular Component | super elongation complex | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | double-stranded DNA binding | |
Biological Process | DNA-templated transcription | |
Biological Process | embryonic hindlimb morphogenesis | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of gene expression | |
Biological Process | response to tumor necrosis factor |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAF4/FMR2 family member 3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP51827
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000215917 | 1-1254 | AF4/FMR2 family member 3 | |||
Sequence: MDSFDLALLQEWDLESLWGEDILSQRNDSLVLEVQASASRCRSVYEPDRNALRRKERERRSQETQQDSGSFNSGYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFGAESRAQPQPSTVCSTASSTPAAVPVQQGKRGAMGWQKAGHPPSDGQQRAAQQGSLRTLLGDGVGRQQTRAKQVCNMETGLQTQERPPAMAAKHGGSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSTETAVHCTAYRGVPANKPESARAKAKLAKFSIPKQAEESRSGENNSCVEEIIREMTWLPPLSAIQAPAKVEPSKFPFPNKDSQLVSSGHSNPKKADAEPGSPDNGASNTSTLEDDLKLSSDDEEGEQQAAQRTALRALADSSVVQQTNCRGSAPSSKGGGSSSSSGGSSSSSDSESTSGSDSETESSSSSSESEGSKPPHCSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGPERNQYYTPPVKDEGQDCGKLPEICQASLRDKELKTTCKEEQRPRTANKAPGSKSVKQKSPPAAVAVTAAALPPAVPSAPTESAPAPTRRSAGKKPTRRTERTSAGDGANCHRPEEPVAPDTLGASVVGPLEPPKTRPCGNNRTGHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYVLSKAPTTTGSEQRLKEAASSNNNSNSNSSTSRASVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEVRSLWVKIDLTLLSRIPEHLSQEPGVLSAPSAKDTDSAPASHALDAPAEKTLPKSKRKRKCDNEDDYREIKKVQGRKESASRLAASTNNTLSGNHCNVNVNSLAIPINKNEKMLRSPTSPLSDTCKHKYASEDLTSSSRPHGNGLLTSASSNKEPKAESQLQTIAGDLTKASHNSSENGTLHSKSRPQTEPWSPGSNGHRDCKRQKLIFDDMPRSADYFMREAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGSSGKSTGSPSPMSPNPSPASSVGSQGSLSSSSGLSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRSSVHLS | ||||||
Modified residue | 782 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 908 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highest levels found in lymphoid tissues, lower levels in brain and lung.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 45-90 | Disordered | ||||
Sequence: YEPDRNALRRKERERRSQETQQDSGSFNSGYSLFSEPYKTNKGDEL | ||||||
Compositional bias | 46-64 | Basic and acidic residues | ||||
Sequence: EPDRNALRRKERERRSQET | ||||||
Compositional bias | 65-80 | Polar residues | ||||
Sequence: QQDSGSFNSGYSLFSE | ||||||
Region | 139-190 | Disordered | ||||
Sequence: AESRAQPQPSTVCSTASSTPAAVPVQQGKRGAMGWQKAGHPPSDGQQRAAQQ | ||||||
Compositional bias | 142-162 | Polar residues | ||||
Sequence: RAQPQPSTVCSTASSTPAAVP | ||||||
Region | 261-324 | Disordered | ||||
Sequence: RPMDGQDQAPDESPKLKSSTETAVHCTAYRGVPANKPESARAKAKLAKFSIPKQAEESRSGENN | ||||||
Region | 350-534 | Disordered | ||||
Sequence: EPSKFPFPNKDSQLVSSGHSNPKKADAEPGSPDNGASNTSTLEDDLKLSSDDEEGEQQAAQRTALRALADSSVVQQTNCRGSAPSSKGGGSSSSSGGSSSSSDSESTSGSDSETESSSSSSESEGSKPPHCSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGPERNQYYTPPVKDEGQD | ||||||
Compositional bias | 413-477 | Polar residues | ||||
Sequence: ALRALADSSVVQQTNCRGSAPSSKGGGSSSSSGGSSSSSDSESTSGSDSETESSSSSSESEGSKP | ||||||
Region | 552-752 | Disordered | ||||
Sequence: KTTCKEEQRPRTANKAPGSKSVKQKSPPAAVAVTAAALPPAVPSAPTESAPAPTRRSAGKKPTRRTERTSAGDGANCHRPEEPVAPDTLGASVVGPLEPPKTRPCGNNRTGHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYVLSKAPTTTGSEQRLKEAASSNNNSNSNSSTSRASVGS | ||||||
Compositional bias | 659-690 | Basic and acidic residues | ||||
Sequence: NRTGHRKELRSSVTCEKRRTRGLSRIVPKSKE | ||||||
Compositional bias | 691-705 | Polar residues | ||||
Sequence: FIETESSSSSSSSDS | ||||||
Compositional bias | 715-752 | Polar residues | ||||
Sequence: VLSKAPTTTGSEQRLKEAASSNNNSNSNSSTSRASVGS | ||||||
Region | 813-883 | Disordered | ||||
Sequence: PGVLSAPSAKDTDSAPASHALDAPAEKTLPKSKRKRKCDNEDDYREIKKVQGRKESASRLAASTNNTLSGN | ||||||
Compositional bias | 838-867 | Basic and acidic residues | ||||
Sequence: EKTLPKSKRKRKCDNEDDYREIKKVQGRKE | ||||||
Compositional bias | 869-883 | Polar residues | ||||
Sequence: ASRLAASTNNTLSGN | ||||||
Region | 919-991 | Disordered | ||||
Sequence: ASEDLTSSSRPHGNGLLTSASSNKEPKAESQLQTIAGDLTKASHNSSENGTLHSKSRPQTEPWSPGSNGHRDC | ||||||
Compositional bias | 924-984 | Polar residues | ||||
Sequence: TSSSRPHGNGLLTSASSNKEPKAESQLQTIAGDLTKASHNSSENGTLHSKSRPQTEPWSPG | ||||||
Compositional bias | 1128-1146 | Polar residues | ||||
Sequence: AAQAPSPWGSSGKSTGSPS | ||||||
Region | 1128-1171 | Disordered | ||||
Sequence: AAQAPSPWGSSGKSTGSPSPMSPNPSPASSVGSQGSLSSSSGLS | ||||||
Compositional bias | 1153-1171 | Polar residues | ||||
Sequence: SPASSVGSQGSLSSSSGLS |
Sequence similarities
Belongs to the AF4 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P51827-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,254
- Mass (Da)136,131
- Last updated2007-01-09 v2
- Checksum240E0CCB568B9478
P51827-2
- Name2
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 18-51 | in Ref. 3; AAA98764 | ||||
Sequence: WGEDILSQRNDSLVLEVQASASRCRSVYEPDRNA → CVSITGQEV | ||||||
Compositional bias | 46-64 | Basic and acidic residues | ||||
Sequence: EPDRNALRRKERERRSQET | ||||||
Compositional bias | 65-80 | Polar residues | ||||
Sequence: QQDSGSFNSGYSLFSE | ||||||
Sequence conflict | 79-80 | in Ref. 3; AAA98764 | ||||
Sequence: SE → RQ | ||||||
Sequence conflict | 84 | in Ref. 3; AAA98764 | ||||
Sequence: T → S | ||||||
Compositional bias | 142-162 | Polar residues | ||||
Sequence: RAQPQPSTVCSTASSTPAAVP | ||||||
Sequence conflict | 145 | in Ref. 3; AAA98764 | ||||
Sequence: P → S | ||||||
Alternative sequence | VSP_022225 | 407 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 413-477 | Polar residues | ||||
Sequence: ALRALADSSVVQQTNCRGSAPSSKGGGSSSSSGGSSSSSDSESTSGSDSETESSSSSSESEGSKP | ||||||
Alternative sequence | VSP_022226 | 564-1254 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 659-690 | Basic and acidic residues | ||||
Sequence: NRTGHRKELRSSVTCEKRRTRGLSRIVPKSKE | ||||||
Compositional bias | 691-705 | Polar residues | ||||
Sequence: FIETESSSSSSSSDS | ||||||
Compositional bias | 715-752 | Polar residues | ||||
Sequence: VLSKAPTTTGSEQRLKEAASSNNNSNSNSSTSRASVGS | ||||||
Compositional bias | 838-867 | Basic and acidic residues | ||||
Sequence: EKTLPKSKRKRKCDNEDDYREIKKVQGRKE | ||||||
Compositional bias | 869-883 | Polar residues | ||||
Sequence: ASRLAASTNNTLSGN | ||||||
Compositional bias | 924-984 | Polar residues | ||||
Sequence: TSSSRPHGNGLLTSASSNKEPKAESQLQTIAGDLTKASHNSSENGTLHSKSRPQTEPWSPG | ||||||
Compositional bias | 1128-1146 | Polar residues | ||||
Sequence: AAQAPSPWGSSGKSTGSPS | ||||||
Compositional bias | 1153-1171 | Polar residues | ||||
Sequence: SPASSVGSQGSLSSSSGLS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC117789 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC122026 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC132381 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC138386 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC052061 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
U34361 EMBL· GenBank· DDBJ | AAA98764.1 EMBL· GenBank· DDBJ | mRNA |