P51827 · AFF3_MOUSE

  • Protein
    AF4/FMR2 family member 3
  • Gene
    Aff3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Putative transcription activator that may function in lymphoid development and oncogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnuclear body
Cellular Componentnucleus
Cellular Componentsuper elongation complex
Molecular FunctionDNA-binding transcription factor activity
Molecular Functiondouble-stranded DNA binding
Biological ProcessDNA-templated transcription
Biological Processembryonic hindlimb morphogenesis
Biological Processregulation of DNA-templated transcription
Biological Processregulation of gene expression
Biological Processresponse to tumor necrosis factor

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    AF4/FMR2 family member 3
  • Alternative names
    • Lymphoid nuclear protein related to AF4 (Protein LAF-4)

Gene names

    • Name
      Aff3
    • Synonyms
      Laf4

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P51827
  • Secondary accessions
    • Q80WS6

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002159171-1254AF4/FMR2 family member 3
Modified residue782Phosphoserine
Modified residue908Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highest levels found in lymphoid tissues, lower levels in brain and lung.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region45-90Disordered
Compositional bias46-64Basic and acidic residues
Compositional bias65-80Polar residues
Region139-190Disordered
Compositional bias142-162Polar residues
Region261-324Disordered
Region350-534Disordered
Compositional bias413-477Polar residues
Region552-752Disordered
Compositional bias659-690Basic and acidic residues
Compositional bias691-705Polar residues
Compositional bias715-752Polar residues
Region813-883Disordered
Compositional bias838-867Basic and acidic residues
Compositional bias869-883Polar residues
Region919-991Disordered
Compositional bias924-984Polar residues
Compositional bias1128-1146Polar residues
Region1128-1171Disordered
Compositional bias1153-1171Polar residues

Sequence similarities

Belongs to the AF4 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P51827-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,254
  • Mass (Da)
    136,131
  • Last updated
    2007-01-09 v2
  • Checksum
    240E0CCB568B9478
MDSFDLALLQEWDLESLWGEDILSQRNDSLVLEVQASASRCRSVYEPDRNALRRKERERRSQETQQDSGSFNSGYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFGAESRAQPQPSTVCSTASSTPAAVPVQQGKRGAMGWQKAGHPPSDGQQRAAQQGSLRTLLGDGVGRQQTRAKQVCNMETGLQTQERPPAMAAKHGGSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSTETAVHCTAYRGVPANKPESARAKAKLAKFSIPKQAEESRSGENNSCVEEIIREMTWLPPLSAIQAPAKVEPSKFPFPNKDSQLVSSGHSNPKKADAEPGSPDNGASNTSTLEDDLKLSSDDEEGEQQAAQRTALRALADSSVVQQTNCRGSAPSSKGGGSSSSSGGSSSSSDSESTSGSDSETESSSSSSESEGSKPPHCSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGPERNQYYTPPVKDEGQDCGKLPEICQASLRDKELKTTCKEEQRPRTANKAPGSKSVKQKSPPAAVAVTAAALPPAVPSAPTESAPAPTRRSAGKKPTRRTERTSAGDGANCHRPEEPVAPDTLGASVVGPLEPPKTRPCGNNRTGHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYVLSKAPTTTGSEQRLKEAASSNNNSNSNSSTSRASVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEVRSLWVKIDLTLLSRIPEHLSQEPGVLSAPSAKDTDSAPASHALDAPAEKTLPKSKRKRKCDNEDDYREIKKVQGRKESASRLAASTNNTLSGNHCNVNVNSLAIPINKNEKMLRSPTSPLSDTCKHKYASEDLTSSSRPHGNGLLTSASSNKEPKAESQLQTIAGDLTKASHNSSENGTLHSKSRPQTEPWSPGSNGHRDCKRQKLIFDDMPRSADYFMREAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGSSGKSTGSPSPMSPNPSPASSVGSQGSLSSSSGLSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRSSVHLS

P51827-2

  • Name
    2
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3YYI6D3YYI6_MOUSEAff31229
F8WJA7F8WJA7_MOUSEAff31228
D6RHR2D6RHR2_MOUSEAff353

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict18-51in Ref. 3; AAA98764
Compositional bias46-64Basic and acidic residues
Compositional bias65-80Polar residues
Sequence conflict79-80in Ref. 3; AAA98764
Sequence conflict84in Ref. 3; AAA98764
Compositional bias142-162Polar residues
Sequence conflict145in Ref. 3; AAA98764
Alternative sequenceVSP_022225407in isoform 2
Compositional bias413-477Polar residues
Alternative sequenceVSP_022226564-1254in isoform 2
Compositional bias659-690Basic and acidic residues
Compositional bias691-705Polar residues
Compositional bias715-752Polar residues
Compositional bias838-867Basic and acidic residues
Compositional bias869-883Polar residues
Compositional bias924-984Polar residues
Compositional bias1128-1146Polar residues
Compositional bias1153-1171Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC117789
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC122026
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC132381
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC138386
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC052061
EMBL· GenBank· DDBJ
-mRNA No translation available.
U34361
EMBL· GenBank· DDBJ
AAA98764.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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