P51796 · CLCN5_RAT

  • Protein
    H(+)/Cl(-) exchange transporter 5
  • Gene
    Clcn5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity).
The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)

Catalytic activity

Features

Showing features for binding site, site.

1816100200300400500600700800
TypeIDPosition(s)Description
Binding site238chloride (UniProtKB | ChEBI)
Site281Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H+ and Cl- transport
Site338Mediates proton transfer from the protein to the inner aqueous phase
Binding site525chloride (UniProtKB | ChEBI)
Binding site628chloride (UniProtKB | ChEBI)
Binding site666ATP (UniProtKB | ChEBI)
Binding site687-689ATP (UniProtKB | ChEBI)
Binding site794-797ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentapical part of cell
Cellular Componentcytosol
Cellular Componentearly endosome
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentsynaptic vesicle
Molecular Functionantiporter activity
Molecular FunctionATP binding
Molecular Functionidentical protein binding
Molecular Functionvoltage-gated chloride channel activity
Biological Processchloride transport
Biological Processendocytosis
Biological Processrenal system process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    H(+)/Cl(-) exchange transporter 5
  • Alternative names
    • Chloride channel protein 5 (ClC-5)
    • Chloride transporter ClC-5

Gene names

    • Name
      Clcn5

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P51796
  • Secondary accessions
    • A0A0G2K839
    • P70642

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-124Cytoplasmic
Transmembrane125-162Helical
Transmembrane208-231Helical
Intramembrane240-247Helical
Transmembrane256-275Helical
Transmembrane281-300Helical
Intramembrane312-324Helical
Intramembrane328-336Helical
Transmembrane348-366Helical
Transmembrane389-414Helical
Transmembrane422-442Helical
Transmembrane498-518Helical
Transmembrane523-542Helical
Intramembrane570-584Helical
Intramembrane585-587Note=Loop between two helices
Intramembrane588-599Helical
Intramembrane600-604Note=Loop between two helices
Transmembrane605-622Helical
Topological domain623-816Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000944481-816H+/Cl- exchange transporter 5

Post-translational modification

Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Kidney specific.

Gene expression databases

Interaction

Subunit

Interacts with NEDD4 and NEDD4L.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif, domain.

TypeIDPosition(s)Description
Motif237-241Selectivity filter part_1
Motif279-283Selectivity filter part_2
Motif523-527Selectivity filter part_3
Domain656-720CBS 1
Domain752-811CBS 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P51796-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    816
  • Mass (Da)
    90,687
  • Last updated
    2020-08-12 v2
  • Checksum
    68AE3812E820141D
MAMWQGAMDNRGFHQGSFSSFQSSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEDRDKCPEWNSWSQLIISTDQGAFAYIVNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFIVLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPMPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPESILFN

P51796-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5ZVV0A0A8I5ZVV0_RATClcn5813

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0606591-70in isoform 2
Sequence conflict385in Ref. 2; BAA09091

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z56277
EMBL· GenBank· DDBJ
CAA91216.1
EMBL· GenBank· DDBJ
mRNA
D50497
EMBL· GenBank· DDBJ
BAA09091.1
EMBL· GenBank· DDBJ
mRNA
AABR07037207
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07037208
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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