P51611 · HCFC1_MESAU
- ProteinHost cell factor 1
- GeneHCFC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2090 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional coregulator (By similarity).
Involved in control of the cell cycle (PubMed:9087427).
Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity).
Coactivator for EGR2 and GABP2 (By similarity).
Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity).
Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity).
Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity).
May negatively modulate transcriptional activity of FOXO3 (By similarity).
Involved in control of the cell cycle (PubMed:9087427).
Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity).
Coactivator for EGR2 and GABP2 (By similarity).
Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity).
Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity).
Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity).
May negatively modulate transcriptional activity of FOXO3 (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 1019-1020 | Cleavage; by autolysis | ||||
Sequence: ET | ||||||
Site | 1081-1082 | Cleavage; by autolysis | ||||
Sequence: ET | ||||||
Site | 1110-1111 | Cleavage; by autolysis | ||||
Sequence: ET | ||||||
Site | 1304-1305 | Cleavage; by autolysis | ||||
Sequence: ET | ||||||
Site | 1332-1333 | Cleavage; by autolysis | ||||
Sequence: ET | ||||||
Site | 1432-1433 | Cleavage; by autolysis | ||||
Sequence: ET |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | histone acetyltransferase complex | |
Cellular Component | MLL1 complex | |
Cellular Component | neuronal cell body | |
Cellular Component | nucleus | |
Cellular Component | Set1C/COMPASS complex | |
Molecular Function | chromatin binding | |
Molecular Function | transcription coactivator activity | |
Biological Process | chromatin organization | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of mitotic cell cycle | |
Biological Process | protein stabilization |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHost cell factor 1
- Short namesHCF ; HCF-1
- Alternative names
- Cleaved into 12 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus
Accessions
- Primary accessionP51611
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 134 | Causes temperature-sensitive cell cycle arrest in a Go-like state. | ||||
Sequence: P → S |
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000016628 | 2-1019 | HCF N-terminal chain 1 | |||
Sequence: ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQGVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCE | ||||||
Chain | PRO_0000016627 | 2-1081 | HCF N-terminal chain 2 | |||
Sequence: ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQGVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCE | ||||||
Chain | PRO_0000016626 | 2-1110 | HCF N-terminal chain 3 | |||
Sequence: ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQGVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCE | ||||||
Chain | PRO_0000016625 | 2-1304 | HCF N-terminal chain 4 | |||
Sequence: ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQGVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRHTSSNPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRSPCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMPTGHQLETYHTYTTNTPTTALSIMGAGELGTARLIPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCE | ||||||
Chain | PRO_0000016624 | 2-1332 | HCF N-terminal chain 5 | |||
Sequence: ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQGVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRHTSSNPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRSPCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMPTGHQLETYHTYTTNTPTTALSIMGAGELGTARLIPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNPPCE | ||||||
Chain | PRO_0000016623 | 2-1432 | HCF N-terminal chain 6 | |||
Sequence: ASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPGSSISVPTAARAQGVPAVLKVTGPQATTGTPLVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQASGAGSKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRHTSSNPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRSPCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMPTGHQLETYHTYTTNTPTTALSIMGAGELGTARLIPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTLESGLEVVAVSTVTSQAGATLLASFPTQRVCSNPPCE | ||||||
Modified residue | 6 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 105 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Cross-link | 163 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Cross-link | 244 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Cross-link | 282 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 288 | N6-acetyllysine | ||||
Sequence: K | ||||||
Cross-link | 363 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Modified residue | 411 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 504 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 524 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 598 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 666 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 669 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 813 | N6-acetyllysine | ||||
Sequence: K | ||||||
Chain | PRO_0000016629 | 1020-2090 | HCF C-terminal chain 1 | |||
Sequence: THETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRHTSSNPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRSPCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMPTGHQLETYHTYTTNTPTTALSIMGAGELGTARLIPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTLESGLEVVAVSTVTSQAGATLLASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESSEVLSASQTPELQAAVDLSSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEVQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Chain | PRO_0000016630 | 1082-2090 | HCF C-terminal chain 2 | |||
Sequence: THETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRHTSSNPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRSPCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMPTGHQLETYHTYTTNTPTTALSIMGAGELGTARLIPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTLESGLEVVAVSTVTSQAGATLLASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESSEVLSASQTPELQAAVDLSSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEVQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Chain | PRO_0000016631 | 1111-2090 | HCF C-terminal chain 3 | |||
Sequence: THETGTTSTATTAMSSMGTGQQRDTRHTSSNPTVVRITVAPGALERTQGTVKPQCQTQQANMTNTTMTVQATRSPCPAGPLLRPSVALEAGNHSPAFVQLALPSVRVGLSGPSNKDMPTGHQLETYHTYTTNTPTTALSIMGAGELGTARLIPTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTLESGLEVVAVSTVTSQAGATLLASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESSEVLSASQTPELQAAVDLSSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEVQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Modified residue | 1204 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1216 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 1223 | Phosphoserine | ||||
Sequence: S | ||||||
Chain | PRO_0000016632 | 1305-2090 | HCF C-terminal chain 4 | |||
Sequence: THETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTLESGLEVVAVSTVTSQAGATLLASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESSEVLSASQTPELQAAVDLSSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEVQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Chain | PRO_0000016633 | 1333-2090 | HCF C-terminal chain 5 | |||
Sequence: THETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTSTGTTMSVSVGALLPDATPSHGTLESGLEVVAVSTVTSQAGATLLASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESSEVLSASQTPELQAAVDLSSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEVQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Chain | PRO_0000016634 | 1433-2090 | HCF C-terminal chain 6 | |||
Sequence: THETGTTHTATTVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETPGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESSEVLSASQTPELQAAVDLSSTGDPSSGQEPTSSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEAAAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEVQAQAQQQHHLPTEALAPADSLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQAAATLTEVDNGIESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Modified residue | 1500 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1506 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1559 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1826 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 1862 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Cross-link | 1863 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Modified residue | 1893 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2060 | N6-acetyllysine | ||||
Sequence: K | ||||||
Cross-link | 2079 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K |
Post-translational modification
Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Cleavage is promoted by O-glycosylation (By similarity).
Further cleavage of the primary N- and C-terminal chains results in a 'trimming' and accumulation of the smaller chains (By similarity).
Cleavage is promoted by O-glycosylation (By similarity).
Further cleavage of the primary N- and C-terminal chains results in a 'trimming' and accumulation of the smaller chains (By similarity).
Cleavage is promoted by O-glycosylation (By similarity).
O-glycosylated. GlcNAcylation by OGT promotes proteolytic processing.
Ubiquitinated. Lys-1862 and Lys-1863 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. BAP1 mediated deubiquitination of 'Lys-48'-linked polyubiquitin chains; deubiquitination by BAP1 does not seem to stabilize the protein.
Keywords
- PTM
Interaction
Subunit
Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa polypeptide. The majority of N- and C-terminal cleavage products remain tightly, albeit non-covalently, associated. Interacts with POU2F1, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1, GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SUDS3), SAP30, SIN3B and FHL2. Component of a MLL1 complex, composed of at least the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, DPY30, E2F6, HCFC2, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8, PELP1, PHF20, PRP31, RING2, RUVBL1, RUVBL2, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Interacts directly with THAP3 (via its HBM). Interacts (via the Kelch-repeat domain) with THAP1 (via the HBM); the interaction recruits HCHC1 to the RRM1. Interacts directly with OGT; the interaction, which requires the HCFC1 cleavage site domain, glycosylates and promotes the proteolytic processing of HCFC1 and retains OGT in the nucleus. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L, CXXC1, HCFC1 and DPY30. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5; the complex is formed as a result of interactions between components of a nuclear receptor-mediated transcription complex and a histone methylation complex (By similarity).
Within the complex interacts with ZNF335 (By similarity).
Interacts with TET2 and TET3. Interacts with HCFC1R1. Interacts with THAP11. Interacts (via Kelch domain) with KMT2E (via HBM motif). Interacts with E2F1. Accessory scaffold component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of BAP1, one of ASXL1, ASXL2 or (probably) ASXL3 and one of MBD5 or MBD6; the PR-DUB core associates with a number of accessory proteins, including FOXK1, FOXK2, KDM1B, HCFC1, YY1 and OGT (By similarity).
Interacts with YY1 (via Gly-rich region); the interaction is direct (By similarity).
Interacts with BAP1 (via HBM-like motif) (By similarity).
Within the complex interacts with ZNF335 (By similarity).
Interacts with TET2 and TET3. Interacts with HCFC1R1. Interacts with THAP11. Interacts (via Kelch domain) with KMT2E (via HBM motif). Interacts with E2F1. Accessory scaffold component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of BAP1, one of ASXL1, ASXL2 or (probably) ASXL3 and one of MBD5 or MBD6; the PR-DUB core associates with a number of accessory proteins, including FOXK1, FOXK2, KDM1B, HCFC1, YY1 and OGT (By similarity).
Interacts with YY1 (via Gly-rich region); the interaction is direct (By similarity).
Interacts with BAP1 (via HBM-like motif) (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 44-89 | Kelch 1 | ||||
Sequence: LIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVC | ||||||
Repeat | 93-140 | Kelch 2 | ||||
Sequence: RLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGH | ||||||
Repeat | 148-194 | Kelch 3 | ||||
Sequence: KCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYG | ||||||
Repeat | 217-265 | Kelch 4 | ||||
Sequence: KLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGN | ||||||
Repeat | 266-313 | Kelch 5 | ||||
Sequence: KMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDT | ||||||
Domain | 366-469 | Fibronectin type-III 1 | ||||
Sequence: PPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVPG | ||||||
Region | 407-434 | Disordered | ||||
Sequence: ATATSPTPNPVPSVPANPPKSPAPAAAA | ||||||
Compositional bias | 414-432 | Pro residues | ||||
Sequence: PNPVPSVPANPPKSPAPAA | ||||||
Region | 500-550 | Required for interaction with OGT | ||||
Sequence: LVTMRPAGQAGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALA | ||||||
Region | 610-722 | Interaction with SIN3A | ||||
Sequence: LKTAAAQVGTSVSSAANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTIL | ||||||
Region | 750-902 | Interaction with ZBTB17 | ||||
Sequence: ILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSTPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHST | ||||||
Region | 813-912 | Interaction with GABP2 | ||||
Sequence: KIITAVPKIATGHGQQGVTQVVLKGAPGQPGAILRTVPMSGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITT | ||||||
Repeat | 1010-1035 | HCF repeat 1 | ||||
Sequence: TLVCSNPPCETHETGTTNTATTTVVA | ||||||
Repeat | 1072-1097 | HCF repeat 2 | ||||
Sequence: VRVCSNPPCETHETGTTNTATTATSN | ||||||
Region | 1098-1140 | Disordered | ||||
Sequence: MAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRHTSS | ||||||
Repeat | 1101-1126 | HCF repeat 3 | ||||
Sequence: QHGCSNPPCETHETGTTSTATTAMSS | ||||||
Repeat | 1157-1182 | HCF repeat 4; degenerate | ||||
Sequence: TQGTVKPQCQTQQANMTNTTMTVQAT | ||||||
Repeat | 1295-1320 | HCF repeat 5 | ||||
Sequence: TQVCSNPPCETHETGTTNTATTSNAG | ||||||
Compositional bias | 1302-1354 | Polar residues | ||||
Sequence: PCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQP | ||||||
Region | 1302-1374 | Disordered | ||||
Sequence: PCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPAGGRPCETHQTTST | ||||||
Repeat | 1323-1348 | HCF repeat 6 | ||||
Sequence: QRVCSNPPCETHETGTTHTATTATSN | ||||||
Repeat | 1358-1383 | HCF repeat 7; degenerate | ||||
Sequence: QQPAGGRPCETHQTTSTGTTMSVSVG | ||||||
Repeat | 1423-1448 | HCF repeat 8 | ||||
Sequence: QRVCSNPPCETHETGTTHTATTVTSN | ||||||
Region | 1444-1486 | Disordered | ||||
Sequence: TVTSNMSSNQDPPPAASDQGEVVSTQGDSANITSSSGITTTVS | ||||||
Domain | 1853-1943 | Fibronectin type-III 2 | ||||
Sequence: PPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTIPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLP | ||||||
Domain | 1945-2061 | Fibronectin type-III 3 | ||||
Sequence: FPGAPCAIKISKSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKD | ||||||
Region | 2049-2090 | Disordered | ||||
Sequence: ATQVRWLQETSKDSSGTKPASKRPMSSPEMKSAPKKSKADGQ | ||||||
Compositional bias | 2052-2070 | Polar residues | ||||
Sequence: VRWLQETSKDSSGTKPASK |
Domain
The HCF repeat is a highly specific proteolytic cleavage signal.
The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller domain which mediates interaction with HCFC1R1.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,090
- Mass (Da)214,942
- Last updated1996-10-01 v1
- ChecksumE495E8B1F2385E17
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 414-432 | Pro residues | ||||
Sequence: PNPVPSVPANPPKSPAPAA | ||||||
Compositional bias | 1302-1354 | Polar residues | ||||
Sequence: PCETHETGTTNTATTSNAGSAQRVCSNPPCETHETGTTHTATTATSNGGAGQP | ||||||
Compositional bias | 2052-2070 | Polar residues | ||||
Sequence: VRWLQETSKDSSGTKPASK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D45419 EMBL· GenBank· DDBJ | BAA08258.1 EMBL· GenBank· DDBJ | mRNA |