P51600 · GCH1_PHYBL
- ProteinGTP cyclohydrolase 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Catalytic activity
- GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+
Activity regulation
GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.
Pathway
Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GTP binding | |
Molecular Function | GTP cyclohydrolase I activity | |
Molecular Function | metal ion binding | |
Biological Process | folic acid biosynthetic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase 1
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Phycomycetaceae > Phycomyces
Accessions
- Primary accessionP51600
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000119487 | 1-94 | GTP cyclohydrolase 1 | |||
Sequence: EDHDEMVIVKDVDIFSLCEHHKVPSTGKISIGYIPNRRVVGLSKLARIAEMFSRRLQVQERLTKQVATALMEILQPQGVAVVVECSHLCMVMRG |
Interaction
Subunit
Toroid-shaped homodecamer, composed of two pentamers of five dimers.
Structure
Sequence
- Sequence statusFragment
- Length94
- Mass (Da)10,586
- Last updated1996-10-01 v1
- Checksum4F8C12A0407A65DD
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E | ||||||
Non-terminal residue | 94 | |||||
Sequence: G |