P51557 · STAR_MOUSE

  • Protein
    Steroidogenic acute regulatory protein, mitochondrial
  • Gene
    Star
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion.

Catalytic activity

Pathway

Steroid metabolism; cholesterol metabolism.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial crista
Cellular Componentmitochondrion
Cellular Componentneuronal cell body
Molecular Functioncholesterol binding
Molecular Functioncholesterol transfer activity
Biological Processbile acid biosynthetic process
Biological Processbiphenyl metabolic process
Biological Processcellular lipid metabolic process
Biological Processcellular response to alkaloid
Biological Processcellular response to antibiotic
Biological Processcellular response to cadmium ion
Biological Processcellular response to cAMP
Biological Processcellular response to dexamethasone stimulus
Biological Processcellular response to epinephrine stimulus
Biological Processcellular response to fibroblast growth factor stimulus
Biological Processcellular response to follicle-stimulating hormone stimulus
Biological Processcellular response to glucose stimulus
Biological Processcellular response to growth hormone stimulus
Biological Processcellular response to insulin stimulus
Biological Processcellular response to interferon-alpha
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to luteinizing hormone stimulus
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processcellular response to type II interferon
Biological Processcholesterol metabolic process
Biological Processcircadian rhythm
Biological Processdibenzo-p-dioxin metabolic process
Biological Processditerpenoid metabolic process
Biological Processestrogen biosynthetic process
Biological Processglucocorticoid metabolic process
Biological Processinsecticide metabolic process
Biological Processintracellular cholesterol transport
Biological Processmale gonad development
Biological Processnegative regulation of neuron apoptotic process
Biological Processphenol-containing compound metabolic process
Biological Processphthalate metabolic process
Biological Processpositive regulation of bile acid biosynthetic process
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of neurogenesis
Biological Processregulation of neuronal synaptic plasticity
Biological Processregulation of steroid biosynthetic process
Biological Processresponse to activity
Biological Processresponse to benzoic acid
Biological Processresponse to corticosterone
Biological Processresponse to estrogen
Biological Processresponse to ethanol
Biological Processresponse to fungicide
Biological Processresponse to herbicide
Biological Processresponse to hydrogen peroxide
Biological Processresponse to ionizing radiation
Biological Processresponse to lead ion
Biological Processresponse to leptin
Biological Processresponse to nicotine
Biological Processresponse to nutrient
Biological Processresponse to retinoic acid
Biological Processsteroid biosynthetic process
Biological Processtestosterone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Steroidogenic acute regulatory protein, mitochondrial
  • Short names
    StAR
  • Alternative names
    • Luteinizing hormone-induced protein
    • START domain-containing protein 1 (StARD1)

Gene names

    • Name
      Star

Organism names

  • Taxonomic identifier
  • Strains
    • 129
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P51557
  • Secondary accessions
    • Q543A5
    • Q924Y5
    • Q9D2G1

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for transit peptide, modified residue, chain.

TypeIDPosition(s)Description
Transit peptide1-62Mitochondrion
Modified residue56Phosphoserine; by PKA
ChainPRO_000003331863-284Steroidogenic acute regulatory protein, mitochondrial
Modified residue194Phosphoserine; by PKA

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed within glia and neurons in discrete regions of the brain.

Gene expression databases

Interaction

Subunit

May interact with TSPO.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain66-279START

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    284
  • Mass (Da)
    31,626
  • Last updated
    1996-10-01 v1
  • Checksum
    9BB13E52D4439B72
MFLATFKLCAGSSYRHMRNMKGLRHQAVLAIGQELNWRALGDSSPGWMGQVRRRSSLLGSQLEATLYSDQELSYIQQGEVAMQKALGILNNQEGWKKESQQENGDEVLSKMVPDVGKVFRLEVVVDQPMDRLYEELVDRMEAMGEWNPNVKEIKVLQRIGKDTVITHELAAAAAGNLVGPRDFVSVRCTKRRGSTCVLAGMATHFGEMPEQSGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKTIINQVLSQTQIEFANHLRKRLEASPASEAQC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1B0GSV6A0A1B0GSV6_MOUSEStar157

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict139in Ref. 3; BAB31842

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L36062
EMBL· GenBank· DDBJ
AAB94783.1
EMBL· GenBank· DDBJ
mRNA
AY032730
EMBL· GenBank· DDBJ
AAK50433.2
EMBL· GenBank· DDBJ
Genomic DNA
AK019725
EMBL· GenBank· DDBJ
BAB31842.1
EMBL· GenBank· DDBJ
mRNA
AK054470
EMBL· GenBank· DDBJ
BAC35791.1
EMBL· GenBank· DDBJ
mRNA
AK136327
EMBL· GenBank· DDBJ
BAE22934.1
EMBL· GenBank· DDBJ
mRNA
BC082283
EMBL· GenBank· DDBJ
AAH82283.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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