P51067 · ACEK_SALTY
- ProteinIsocitrate dehydrogenase kinase/phosphatase
- GeneaceK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids583 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
Catalytic activity
- ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H+ + O-phospho-L-seryl-[isocitrate dehydrogenase]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | [isocitrate dehydrogenase (NADP+)] kinase activity | |
Molecular Function | AMP binding | |
Molecular Function | ATP binding | |
Molecular Function | phosphoprotein phosphatase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | glucose metabolic process | |
Biological Process | glyoxylate cycle | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIsocitrate dehydrogenase kinase/phosphatase
- EC number
- Short namesIDH kinase/phosphatase ; IDHK/P
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionP51067
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 2 | in strain: S2980 and S2983 | ||||
Sequence: P → S | ||||||
Natural variant | 4 | in strain: S2978 and S2979 | ||||
Sequence: G → C | ||||||
Natural variant | 20 | in strain: S3333 | ||||
Sequence: Q → R | ||||||
Natural variant | 41 | in strain: S2978 and S2979 | ||||
Sequence: H → Q | ||||||
Natural variant | 73 | in strain: S2980 and S2983 | ||||
Sequence: S → N | ||||||
Natural variant | 77 | in strain: S2980, S2983, S3013, S3014, S3015 and S3027 | ||||
Sequence: D → N | ||||||
Natural variant | 146-147 | in strain: S3041 and S3044 | ||||
Sequence: DH → EQ | ||||||
Natural variant | 151 | in strain: S2980 and S2983 | ||||
Sequence: P → L | ||||||
Natural variant | 151 | in strain: S2978, S2979 and S2993 | ||||
Sequence: P → S | ||||||
Natural variant | 154 | in strain: S3041 and S3044 | ||||
Sequence: M → V | ||||||
Natural variant | 156 | in strain: S3044 | ||||
Sequence: I → M | ||||||
Natural variant | 163 | in strain: S3333 | ||||
Sequence: R → C | ||||||
Natural variant | 167 | in strain: S3015 and S3027 | ||||
Sequence: Q → L | ||||||
Natural variant | 170 | in strain: S3013, S3014, S3015 and S3027 | ||||
Sequence: S → R | ||||||
Natural variant | 174 | in strain: S3041 and S3044 | ||||
Sequence: R → H | ||||||
Natural variant | 181 | in strain: S3015 and S3027 | ||||
Sequence: T → A | ||||||
Natural variant | 183 | in strain: S3015 and S3027 | ||||
Sequence: T → A | ||||||
Natural variant | 183 | in strain: S2980 and S2983 | ||||
Sequence: T → I | ||||||
Natural variant | 184 | in strain: S3041 and S3044 | ||||
Sequence: L → F | ||||||
Natural variant | 186-188 | in strain: S3041 and S3044 | ||||
Sequence: EDA → AEG | ||||||
Natural variant | 188 | in strain: S3014 | ||||
Sequence: A → G | ||||||
Natural variant | 194 | in strain: S2980, S2983, S3041 and S3044 | ||||
Sequence: V → L | ||||||
Natural variant | 197 | in strain: S3041 | ||||
Sequence: A → T | ||||||
Natural variant | 213-214 | in strain: S3041 and S3044 | ||||
Sequence: LT → FI | ||||||
Natural variant | 214 | in strain: S2980 and S2983 | ||||
Sequence: T → A | ||||||
Natural variant | 303 | in strain: S3041 and S3044 | ||||
Sequence: C → G | ||||||
Natural variant | 307 | in strain: S3041 and S3044 | ||||
Sequence: E → N | ||||||
Natural variant | 348 | in strain: S3041 and S3044 | ||||
Sequence: M → V | ||||||
Natural variant | 383-384 | in strain: S3041 and S3044 | ||||
Sequence: RQ → QR | ||||||
Natural variant | 391 | in strain: S2995 and S3057 | ||||
Sequence: A → T | ||||||
Natural variant | 394 | in strain: S2980, S2983, S3041 and S3044 | ||||
Sequence: R → Q | ||||||
Natural variant | 407 | in strain: S2978, S2979, S2993, S2995, S3013, S3014, S3015, S3027, S3041, S3044 and S3057 | ||||
Sequence: H → Q | ||||||
Natural variant | 409 | in strain: S3041 and S3044 | ||||
Sequence: V → A | ||||||
Natural variant | 411 | in strain: S2993 | ||||
Sequence: R → C | ||||||
Natural variant | 429 | in strain: S3041 and S3044 | ||||
Sequence: V → A | ||||||
Natural variant | 486 | in strain: S3041 and S3044 | ||||
Sequence: N → H | ||||||
Natural variant | 492 | in strain: S3044 | ||||
Sequence: P → T | ||||||
Natural variant | 501 | in strain: S2979 | ||||
Sequence: A → S | ||||||
Natural variant | 502 | in strain: S3041 and S3044 | ||||
Sequence: S → C | ||||||
Natural variant | 510-511 | in strain: S2979 | ||||
Sequence: PG → RC | ||||||
Natural variant | 547 | in strain: S3041 and S3044 | ||||
Sequence: A → G | ||||||
Natural variant | 554 | in strain: S3041 and S3044 | ||||
Sequence: E → N | ||||||
Natural variant | 557 | in strain: S2978, S2979 and S2993 | ||||
Sequence: V → I | ||||||
Natural variant | 570 | in strain: S2978, S2979, S2995 and S3057 | ||||
Sequence: S → G | ||||||
Natural variant | 574-583 | in strain: S2980 and S2983 | ||||
Sequence: GAISSTANSS → DIDRRLDKAPAPAGNVCRTA | ||||||
Natural variant | 574-583 | in strain: S3333 | ||||
Sequence: GAISSTANSS → ETDRRPDKAFAPPSGNVRRA | ||||||
Natural variant | 576-583 | in strain: S2995 and S3057 | ||||
Sequence: ISSTANSS → KEASPL | ||||||
Natural variant | 578 | in strain: S3041 and S3044 | ||||
Sequence: S → T | ||||||
Natural variant | 580 | in strain: S3015, S3027, S3041 and S3044 | ||||
Sequence: A → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 49 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000057909 | 1-583 | Isocitrate dehydrogenase kinase/phosphatase | |||
Sequence: MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKSRIHLYDHHVGLVVEQLRCITDGKSTDADFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFFPDHGWEPLLMRILSDLPLRLPWQNKSRDIRYIIAHLTETLGEDALPRCHVQVANELFYRNKAAWLVGKLTTPDGTLPFLLPIHRTDEGELFVDTCLTTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLCYLAESDEKFIEAPGIRGMVMLVFTLPGFDRVFKIIKDKFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLDKRQIDPALMALLRQEAPEKITDLGEHIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQTRIKEGHVEDVYAYRRRQRFSVRYGAISSTANSS |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length583
- Mass (Da)67,956
- Last updated2002-01-23 v2
- Checksum6214DEB7D8ACD04E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U43344 EMBL· GenBank· DDBJ | AAC43868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43345 EMBL· GenBank· DDBJ | AAC43870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43347 EMBL· GenBank· DDBJ | AAC43873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43348 EMBL· GenBank· DDBJ | AAC43875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43349 EMBL· GenBank· DDBJ | AAC43877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43350 EMBL· GenBank· DDBJ | AAC43879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43351 EMBL· GenBank· DDBJ | AAC43881.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43352 EMBL· GenBank· DDBJ | AAC43883.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43353 EMBL· GenBank· DDBJ | AAC43885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43354 EMBL· GenBank· DDBJ | AAC43887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43355 EMBL· GenBank· DDBJ | AAC43889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43356 EMBL· GenBank· DDBJ | AAC43891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43357 EMBL· GenBank· DDBJ | AAC43893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43358 EMBL· GenBank· DDBJ | AAC43895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U43359 EMBL· GenBank· DDBJ | AAC43897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE006468 EMBL· GenBank· DDBJ | AAL23009.1 EMBL· GenBank· DDBJ | Genomic DNA |