P50815 · VL1_HPV43
- ProteinMajor capsid protein L1
- GeneL1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids531 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Cellular Component | T=7 icosahedral viral capsid | |
Molecular Function | structural molecule activity | |
Biological Process | endocytosis involved in viral entry into host cell | |
Biological Process | virion attachment to host cell |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMajor capsid protein L1
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 8
- Virus hosts
Accessions
- Primary accessionP50815
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000133527 | 1-531 | Major capsid protein L1 | |||
Sequence: MALIFICILHCGIWANAVNAFHIFLQITMWRLNDNKVYLPPPGPIASIVSTDEYVQRTNLFYYAGSSRLLAVGHPYFPLKNSSGKITVPKVSGYQYRVFRVKLPDPNKFGFSETTLVTSDTQRLVWGCVGVEIGRGQPLGVGISGHPYLNKYDDTENPSGYGTSPGQDNRENVAMDYKQTQLCIVGCTPPMGEYWGQGVPCNASGVTQGDCPVIELKSEVIQDGDMVDTGFGAMDFASLQASKSDVPLDLVNTKSKYPDYLGMAAEPYGNSLFFFLRREQMFLRHFFNKAGKTGDVVPSDMYIAGSNTRSKIADSIYFSTPSGSLVTSDSQLFNKPLWIQKAQGHNNGICFGNQLFVTVVDTTRSTNLTLCASTDPTVPSTYDNAKFKEYLRHVEEYDLQFIFQLCIITLNPEVMTYIHTMDPTLLEDWNFGVSPPASASLEDTYRFLSNKAIACQKNAPPKEREDPYKKYTFWDINLTEKFSAQLTQFPLGRKFVMQAGLRPKPKLKTVKRSAPSSSTSAPASKRKKTKR | ||||||
Disulfide bond | 201 | Interchain (with C-455) | ||||
Sequence: C | ||||||
Disulfide bond | 455 | Interchain (with C-201) | ||||
Sequence: C |
Keywords
- PTM
Expression
Keywords
- Developmental stage
Interaction
Subunit
Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation. Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation.
Sequence
- Sequence statusComplete
- Length531
- Mass (Da)59,213
- Last updated2005-09-27 v2
- ChecksumE1AFB0EBAD0FD816
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 493 | in Ref. 2; AAA67248 | ||||
Sequence: R → A |