P50746 · CADH_EUCBO

Function

function

Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Aromatic compound metabolism; phenylpropanoid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site49NADP+ (UniProtKB | ChEBI)
Binding site69Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site70Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site100Zn2+ 2 (UniProtKB | ChEBI)
Binding site103Zn2+ 2 (UniProtKB | ChEBI)
Binding site106Zn2+ 2 (UniProtKB | ChEBI)
Binding site114Zn2+ 2 (UniProtKB | ChEBI)
Binding site162Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site166NADP+ (UniProtKB | ChEBI)
Binding site187-192NADP+ (UniProtKB | ChEBI)
Binding site210-215NADP+ (UniProtKB | ChEBI)
Binding site250NADP+ (UniProtKB | ChEBI)
Binding site274NADP+ (UniProtKB | ChEBI)
Binding site297-299NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncinnamyl-alcohol dehydrogenase activity
Molecular Functionconiferyl-alcohol dehydrogenase activity
Molecular Functionzinc ion binding
Biological Processlignin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cinnamyl alcohol dehydrogenase
  • EC number
  • Short names
    CAD

Gene names

    • Name
      CAD1

Organism names

Accessions

  • Primary accession
    P50746

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001607921-355Probable cinnamyl alcohol dehydrogenase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    38,679
  • Last updated
    1996-10-01 v1
  • Checksum
    8F1D067A409D629A
MGSLEKERTTTGWAARDPSGVLSPYTYSLRNTGPEDLYIKVLSCGICHSDIHQIKNDLGMSHYPMVPGHEVVGEVLEVGSEVTKYRVGDRVGTGIVVGCCRSCGPCNSDQEQYCNKKIWNYNDVYTDGKPTQGGFAGEIVVGQRFVVKIPDGLESEQDAVMCAGVTVYSPLVRFGLKQSGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSDKKRTEALEHLGADAYLVSSDENGMKEATDSLDYIFDTIPVVHPLEPYLALLKLDGKLILTGVINAPLQFISPMVMLGRKSITGSFIGSMKETEEMLEFCKEKGLTSQIEVIKMDYVNTALERLEKNDVRYRFVVDVAGSKLD

Sequence caution

The sequence BAA04046.1 differs from that shown. Reason: Erroneous gene model prediction

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D16624
EMBL· GenBank· DDBJ
BAA04046.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Similar Proteins

Disclaimer

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