P50501 · AQPA_PELLE
- ProteinAquaporin FA-CHIP
- GeneAQPA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids272 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Forms a water-specific channel.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 193 | Hg2+-sensitive residue | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ammonium channel activity | |
Molecular Function | carbon dioxide transmembrane transporter activity | |
Molecular Function | glycerol transmembrane transporter activity | |
Molecular Function | water channel activity | |
Biological Process | glycerol transmembrane transport | |
Biological Process | hyperosmotic response | |
Biological Process | renal water transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAquaporin FA-CHIP
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Neobatrachia > Ranoidea > Ranidae > Pelophylax
Accessions
- Primary accessionP50501
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-17 | Cytoplasmic | |||
Transmembrane | 18-35 | Helical | |||
Topological domain | 36-52 | Extracellular | |||
Transmembrane | 53-71 | Helical | |||
Topological domain | 72-97 | Cytoplasmic | |||
Transmembrane | 98-119 | Helical | |||
Topological domain | 120-139 | Extracellular | |||
Transmembrane | 140-160 | Helical | |||
Topological domain | 161-168 | Cytoplasmic | |||
Transmembrane | 169-188 | Helical | |||
Topological domain | 189-214 | Extracellular | |||
Transmembrane | 215-236 | Helical | |||
Topological domain | 237-272 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000063973 | 1-272 | Aquaporin FA-CHIP | ||
Glycosylation | 44 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 125 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 209 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 80-82 | NPA 1 | |||
Motif | 196-198 | NPA 2 | |||
Domain
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length272
- Mass (Da)28,881
- Last updated1996-10-01 v1
- Checksum9E79B4BD4E168BD2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L24754 EMBL· GenBank· DDBJ | AAC38016.1 EMBL· GenBank· DDBJ | mRNA |