P50432 · GLYC_CAEEL

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    mel-32
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Interconversion of serine and glycine.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processembryo development ending in birth or egg hatching
Biological Processglycine biosynthetic process from serine
Biological Processserine family amino acid metabolic process
Biological Processtetrahydrofolate interconversion
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
  • Alternative names
    • Glycine hydroxymethyltransferase
    • Glycosylation-related protein 1
    • Maternal effect lethal protein 32
    • Serine methylase

Gene names

    • Name
      mel-32
    • Synonyms
      gly-1
    • ORF names
      C05D11.11

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P50432
  • Secondary accessions
    • Q95QX8

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis86In t1473; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype; when associated with F-169.
Mutagenesis107In t1597; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis125In t1555; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis126In t1666; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis149In s2518; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis166In t1679; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis169In t1473; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype; when associated with V-86.
Mutagenesis172In t1665; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis227In t1552; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis274In t1520; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis282In t1607; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis291In t1616; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis336In t1456; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis395In t1576; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Mutagenesis429In t1632; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001135081-507Serine hydroxymethyltransferase
Modified residue283N6-(pyridoxal phosphate)lysine

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P50432-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    507
  • Mass (Da)
    55,765
  • Last updated
    2002-08-02 v2
  • Checksum
    693B380E77BB07D8
MFARIVSRRAATGLFAGASSQCKMADRQVHTPLAKVQRHKYTNNENILVDHVEKVDPEVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQMELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGGHLTHGFFTPARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGALIFYRKGVRSTNAKGVDTLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALRQCLSEDFVQYGEQVLKNAKTLAERMKKHGYALATGGTDNHLLLVDLRPIGVEGARAEHVLDLAHIACNKNTCPGDVSALRPGGIRLGTPALTSRGFQEQDFEKVGDFIHEGVQIAKKYNAEAGKTLKDFKSFTETNEPFKKDVADLAKRVEEFSTKFEIPGNETF

P50432-2

  • Name
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0060971-23in isoform a

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO080365
EMBL· GenBank· DDBJ
CCD63201.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080365
EMBL· GenBank· DDBJ
CCD63202.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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