P50432 · GLYC_CAEEL
- ProteinSerine hydroxymethyltransferase
- Genemel-32
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids507 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Interconversion of serine and glycine.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | glycine hydroxymethyltransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | embryo development ending in birth or egg hatching | |
Biological Process | glycine biosynthetic process from serine | |
Biological Process | serine family amino acid metabolic process | |
Biological Process | tetrahydrofolate interconversion | |
Biological Process | tetrahydrofolate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine hydroxymethyltransferase
- EC number
- Short namesSHMT
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionP50432
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 86 | In t1473; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype; when associated with F-169. | ||||
Sequence: A → V | ||||||
Mutagenesis | 107 | In t1597; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: R → Q | ||||||
Mutagenesis | 125 | In t1555; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: R → K | ||||||
Mutagenesis | 126 | In t1666; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: A → V | ||||||
Mutagenesis | 149 | In s2518; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: A → V | ||||||
Mutagenesis | 166 | In t1679; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: G → D | ||||||
Mutagenesis | 169 | In t1473; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype; when associated with V-86. | ||||
Sequence: L → F | ||||||
Mutagenesis | 172 | In t1665; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: G → E | ||||||
Mutagenesis | 227 | In t1552; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: G → E | ||||||
Mutagenesis | 274 | In t1520; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: S → F | ||||||
Mutagenesis | 282 | In t1607; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: H → Y | ||||||
Mutagenesis | 291 | In t1616; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: A → T | ||||||
Mutagenesis | 336 | In t1456; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: G → E | ||||||
Mutagenesis | 395 | In t1576; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: G → R | ||||||
Mutagenesis | 429 | In t1632; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype. | ||||
Sequence: G → E |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000113508 | 1-507 | Serine hydroxymethyltransferase | |||
Sequence: MFARIVSRRAATGLFAGASSQCKMADRQVHTPLAKVQRHKYTNNENILVDHVEKVDPEVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQMELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGGHLTHGFFTPARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGALIFYRKGVRSTNAKGVDTLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALRQCLSEDFVQYGEQVLKNAKTLAERMKKHGYALATGGTDNHLLLVDLRPIGVEGARAEHVLDLAHIACNKNTCPGDVSALRPGGIRLGTPALTSRGFQEQDFEKVGDFIHEGVQIAKKYNAEAGKTLKDFKSFTETNEPFKKDVADLAKRVEEFSTKFEIPGNETF | ||||||
Modified residue | 283 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P50432-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length507
- Mass (Da)55,765
- Last updated2002-08-02 v2
- Checksum693B380E77BB07D8
P50432-2
- Namea
- Differences from canonical
- 1-23: Missing
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_006097 | 1-23 | in isoform a | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO080365 EMBL· GenBank· DDBJ | CCD63201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080365 EMBL· GenBank· DDBJ | CCD63202.1 EMBL· GenBank· DDBJ | Genomic DNA |