P50239 · E75_GALME

Function

function

Orphan receptor possibly involved in the regulation of genes in the ecdysteroid cascade.

Features

Showing features for dna binding.

1711100200300400500600700
TypeIDPosition(s)Description
DNA binding44-120Nuclear receptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionnuclear receptor activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processcell differentiation
Biological Processhormone-mediated signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ecdysone-inducible protein E75
  • Alternative names
    • Nuclear receptor subfamily 1 group D member 3

Gene names

    • Name
      E75
    • Synonyms
      NR1D3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Pyraloidea > Pyralidae > Galleriinae > Galleria

Accessions

  • Primary accession
    P50239
  • Secondary accessions
    • Q24994

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000535081-711Ecdysone-inducible protein E75

Expression

Induction

Expression is induced by 20-OH-ecdysone which initiates and coordinates the molts.

Developmental stage

Both isoforms first expressed in stage-2 larvae and then highly expressed during larval and pupal molts. Only isoform E75A is expressed at the time of pupal ecdysis.

Structure

Family & Domains

Features

Showing features for zinc finger, domain, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger47-67NR C4-type
Zinc finger84-108NR C4-type
Domain153-400NR LBD
Region405-432Disordered
Compositional bias412-431Polar residues
Region466-530Disordered
Compositional bias478-500Basic and acidic residues
Compositional bias511-526Basic and acidic residues
Region559-602Disordered
Compositional bias574-597Pro residues
Region680-711Disordered
Compositional bias689-711Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist. Isoforms differ in their N-termini.

P50239-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    E75A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    711
  • Mass (Da)
    78,530
  • Last updated
    1996-10-01 v1
  • Checksum
    BA591C6E7735B6EC
MTLVMSPDSSYGRYDAPAPADNRIMSPVHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQSSTTRAHEQAAAAELDDGPRLLARVVRAHLDTCEFTRDRVAAMRNGARDCPTYSQPTLACPLNPAPELQSEKEFSQRFAHVIRGVIDFAGLIPGFQLLTQDDKFTLLKSGLFDALFVRLICMFDAPLNSIICLNGQLMKRDSIQSGANARFLVDSTFKFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNVELVERMHSRLKSCLQTVIAQNRSDGPGFLRELMDTLPDLRTLSTLHTEKLVVFRTEHKELLRQQMWVEDEGALWADSGADDSARSPIGSVSSSESSETTGDCGTPLLAATLAGRRRLDSRGSVDEEALGVAHLAHNGLTVTPVRPPPRYRKLDSPTDSGIESGNEKHERIVGPESGCSSPRSSLEEHSDDRRPIAPADDMPVLKRVLQAPPLYDASSLMDEAYKPHKKFRAMRRDTWSEAEARPGRPTPSPQPPHHPHPASPAHPAHSPRPIRAPLSSTHSVLAKSLMEGPRMTPEQLKRTDIIQQYMRRGETGAPTEGCPLRAGGLLTCFRGASPAPQPVIALQVDVAETDAPQPLNLSKKSPSPSPPPPPPRSYMPPMLPA

P50239-2

  • Name
    2
  • Synonyms
    E75B
  • Note
    Lacks the first zinc-finger.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-68: MTLVMSPDSSYGRYDAPAPADNRIMSPVHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCK → MVRAMSCGAELRERHSVLVSMLESRRESSDSGCSSDESSDLERNSNCRCDSQ

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0036521-68in isoform 2
Compositional bias412-431Polar residues
Compositional bias478-500Basic and acidic residues
Compositional bias511-526Basic and acidic residues
Compositional bias574-597Pro residues
Compositional bias689-711Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U02620
EMBL· GenBank· DDBJ
AAA19579.1
EMBL· GenBank· DDBJ
mRNA
U51008
EMBL· GenBank· DDBJ
AAA93484.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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