P50239 · E75_GALME
- ProteinEcdysone-inducible protein E75
- GeneE75
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids711 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Orphan receptor possibly involved in the regulation of genes in the ecdysteroid cascade.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 44-120 | Nuclear receptor | ||||
Sequence: TVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRF |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | nuclear receptor activity | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | cell differentiation | |
Biological Process | hormone-mediated signaling pathway | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEcdysone-inducible protein E75
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Pyraloidea > Pyralidae > Galleriinae > Galleria
Accessions
- Primary accessionP50239
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053508 | 1-711 | Ecdysone-inducible protein E75 | |||
Sequence: MTLVMSPDSSYGRYDAPAPADNRIMSPVHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQSSTTRAHEQAAAAELDDGPRLLARVVRAHLDTCEFTRDRVAAMRNGARDCPTYSQPTLACPLNPAPELQSEKEFSQRFAHVIRGVIDFAGLIPGFQLLTQDDKFTLLKSGLFDALFVRLICMFDAPLNSIICLNGQLMKRDSIQSGANARFLVDSTFKFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNVELVERMHSRLKSCLQTVIAQNRSDGPGFLRELMDTLPDLRTLSTLHTEKLVVFRTEHKELLRQQMWVEDEGALWADSGADDSARSPIGSVSSSESSETTGDCGTPLLAATLAGRRRLDSRGSVDEEALGVAHLAHNGLTVTPVRPPPRYRKLDSPTDSGIESGNEKHERIVGPESGCSSPRSSLEEHSDDRRPIAPADDMPVLKRVLQAPPLYDASSLMDEAYKPHKKFRAMRRDTWSEAEARPGRPTPSPQPPHHPHPASPAHPAHSPRPIRAPLSSTHSVLAKSLMEGPRMTPEQLKRTDIIQQYMRRGETGAPTEGCPLRAGGLLTCFRGASPAPQPVIALQVDVAETDAPQPLNLSKKSPSPSPPPPPPRSYMPPMLPA |
Expression
Induction
Expression is induced by 20-OH-ecdysone which initiates and coordinates the molts.
Developmental stage
Both isoforms first expressed in stage-2 larvae and then highly expressed during larval and pupal molts. Only isoform E75A is expressed at the time of pupal ecdysis.
Structure
Family & Domains
Features
Showing features for zinc finger, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 47-67 | NR C4-type | ||||
Sequence: CRVCGDKASGFHYGVHSCEGC | ||||||
Zinc finger | 84-108 | NR C4-type | ||||
Sequence: CTKNQQCSILRINRNRCQYCRLKKC | ||||||
Domain | 153-400 | NR LBD | ||||
Sequence: DGPRLLARVVRAHLDTCEFTRDRVAAMRNGARDCPTYSQPTLACPLNPAPELQSEKEFSQRFAHVIRGVIDFAGLIPGFQLLTQDDKFTLLKSGLFDALFVRLICMFDAPLNSIICLNGQLMKRDSIQSGANARFLVDSTFKFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNVELVERMHSRLKSCLQTVIAQNRSDGPGFLRELMDTLPDLRTLSTLHTEKLVVFRTEHKELLRQQMWVEDEGA | ||||||
Region | 405-432 | Disordered | ||||
Sequence: SGADDSARSPIGSVSSSESSETTGDCGT | ||||||
Compositional bias | 412-431 | Polar residues | ||||
Sequence: RSPIGSVSSSESSETTGDCG | ||||||
Region | 466-530 | Disordered | ||||
Sequence: LTVTPVRPPPRYRKLDSPTDSGIESGNEKHERIVGPESGCSSPRSSLEEHSDDRRPIAPADDMPV | ||||||
Compositional bias | 478-500 | Basic and acidic residues | ||||
Sequence: RKLDSPTDSGIESGNEKHERIVG | ||||||
Compositional bias | 511-526 | Basic and acidic residues | ||||
Sequence: SLEEHSDDRRPIAPAD | ||||||
Region | 559-602 | Disordered | ||||
Sequence: AMRRDTWSEAEARPGRPTPSPQPPHHPHPASPAHPAHSPRPIRA | ||||||
Compositional bias | 574-597 | Pro residues | ||||
Sequence: RPTPSPQPPHHPHPASPAHPAHSP | ||||||
Region | 680-711 | Disordered | ||||
Sequence: DAPQPLNLSKKSPSPSPPPPPPRSYMPPMLPA | ||||||
Compositional bias | 689-711 | Pro residues | ||||
Sequence: KKSPSPSPPPPPPRSYMPPMLPA |
Sequence similarities
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist. Isoforms differ in their N-termini.
P50239-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsE75A
- Length711
- Mass (Da)78,530
- Last updated1996-10-01 v1
- ChecksumBA591C6E7735B6EC
P50239-2
- Name2
- SynonymsE75B
- NoteLacks the first zinc-finger.
- Differences from canonical
- 1-68: MTLVMSPDSSYGRYDAPAPADNRIMSPVHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCK → MVRAMSCGAELRERHSVLVSMLESRRESSDSGCSSDESSDLERNSNCRCDSQ
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_003652 | 1-68 | in isoform 2 | |||
Sequence: MTLVMSPDSSYGRYDAPAPADNRIMSPVHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCK → MVRAMSCGAELRERHSVLVSMLESRRESSDSGCSSDESSDLERNSNCRCDSQ | ||||||
Compositional bias | 412-431 | Polar residues | ||||
Sequence: RSPIGSVSSSESSETTGDCG | ||||||
Compositional bias | 478-500 | Basic and acidic residues | ||||
Sequence: RKLDSPTDSGIESGNEKHERIVG | ||||||
Compositional bias | 511-526 | Basic and acidic residues | ||||
Sequence: SLEEHSDDRRPIAPAD | ||||||
Compositional bias | 574-597 | Pro residues | ||||
Sequence: RPTPSPQPPHHPHPASPAHPAHSP | ||||||
Compositional bias | 689-711 | Pro residues | ||||
Sequence: KKSPSPSPPPPPPRSYMPPMLPA |
Keywords
- Coding sequence diversity
- Technical term