P49869 · HR38_DROME

Function

function

Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.

Features

Showing features for dna binding.

110731002003004005006007008009001,000
TypeIDPosition(s)Description
DNA binding741-816Nuclear receptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular Functioncore promoter sequence-specific DNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionnuclear glucocorticoid receptor binding
Molecular Functionnuclear receptor activity
Molecular Functionprotein heterodimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific DNA binding
Molecular Functionsignaling receptor binding
Molecular Functionzinc ion binding
Biological Processcellular response to corticotropin-releasing hormone stimulus
Biological Processcuticle development
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of adult chitin-containing cuticle pigmentation
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable nuclear hormone receptor HR38
  • Short names
    dHR38
  • Alternative names
    • Nuclear receptor subfamily 4 group A member 4

Gene names

    • Name
      Hr38
    • Synonyms
      NR4A4
    • ORF names
      CG1864

Organism names

  • Taxonomic identifier
  • Strains
    • Berkeley
    • Canton-S
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P49869
  • Secondary accessions
    • O18383
    • Q9VIK4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000537251-1073Probable nuclear hormone receptor HR38

Proteomic databases

Expression

Tissue specificity

Ubiquitously expressed in preblastoderm embryos, specifically in central nervous system and intestinal tract. Highly expressed in third instar larval imaginal disks and brain complexes, but not in ovaries.

Developmental stage

Low levels in 0-8 hours embryos and adults. Higher in late embryogenesis and during larval and pupal stages. Short isoform is enriched in pupae and adults, long isoform in larvae.

Gene expression databases

Interaction

Subunit

Forms a heterodimer with USP.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, zinc finger, domain.

TypeIDPosition(s)Description
Compositional bias55-81Polar residues
Region55-87Disordered
Region150-185Disordered
Compositional bias263-279Polar residues
Region263-326Disordered
Compositional bias290-326Polar residues
Region437-458Disordered
Region492-514Disordered
Region529-579Disordered
Compositional bias537-579Polar residues
Region618-640Disordered
Zinc finger744-764NR C4-type
Zinc finger780-804NR C4-type
Region819-841Disordered
Domain840-1070NR LBD

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P49869-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,073
  • Mass (Da)
    116,992
  • Last updated
    2000-12-01 v3
  • Checksum
    126A30DAFA1C096A
MMRDRLASLIVVKQEGGSNTSISHHQATAIKCEASLYTESSLFQEINNNSCYRQNLNAPTHQQSHTSHLQHAQQHQTHQQHPLLPPPLPTLPLIYPCRNLFPDGCDINHLACCSSSNSNSNCNSDSNSTSSSPGNSHFFANGNTCAAALTPAPPATEPRKIKPLGAGKLKVGKTDSNSDSNSNCDSRAAAAASTSATSATSATTLAATAAATAAAAEAGGAASAAAAAKISQVRLTNQATTSMLLLQPNSSFSSLSPFDNFSTQTASTTTTTSASAAGHHQHHNHLLHQQHHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSPQQHLLKSETLLSHEEDQLISNLTDSSVVSHSELFSDLFFPSDSNNSLLSPTTSGYPDNPAEDLTSSIENLTKLTCLRDKRLSSIPEQQLSSEQEQQLCLLSLRSSSDPAIALHAQQQQQQQQQQQQQQQQHQQQQQHLQLQLISPIGGPLSCGSSLPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAAAATVGGPPPVRRASLPVQRTVSPAGSTAQSPKLAKITLNQRHSHAHAHALQLNSAPNSAASSPASADLQAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSPQESPPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTTLPF

P49869-2

  • Name
    Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E1JHM7E1JHM7_DROMEHr38836

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0037141-522in isoform Short
Compositional bias55-81Polar residues
Compositional bias263-279Polar residues
Compositional bias290-326Polar residues
Compositional bias537-579Polar residues
Sequence conflict667in Ref. 4; AAF53914
Sequence conflict685in Ref. 1 and 3
Sequence conflict689-692in Ref. 2; CAA75690
Sequence conflict697in Ref. 2; CAA75690
Sequence conflict702in Ref. 2; CAA75690
Sequence conflict1041in Ref. 2; CAA75690
Sequence conflict1064in Ref. 2; CAA75690

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X89246
EMBL· GenBank· DDBJ
CAA61534.1
EMBL· GenBank· DDBJ
mRNA
Y15606
EMBL· GenBank· DDBJ
CAA75690.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ002073
EMBL· GenBank· DDBJ
CAA05172.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
AAF53914.1
EMBL· GenBank· DDBJ
Genomic DNA
U36762
EMBL· GenBank· DDBJ
AAC46926.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp