P49869 · HR38_DROME
- ProteinProbable nuclear hormone receptor HR38
- GeneHr38
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1073 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 741-816 | Nuclear receptor | ||||
Sequence: SQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRT |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable nuclear hormone receptor HR38
- Short namesdHR38
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP49869
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053725 | 1-1073 | Probable nuclear hormone receptor HR38 | |||
Sequence: MMRDRLASLIVVKQEGGSNTSISHHQATAIKCEASLYTESSLFQEINNNSCYRQNLNAPTHQQSHTSHLQHAQQHQTHQQHPLLPPPLPTLPLIYPCRNLFPDGCDINHLACCSSSNSNSNCNSDSNSTSSSPGNSHFFANGNTCAAALTPAPPATEPRKIKPLGAGKLKVGKTDSNSDSNSNCDSRAAAAASTSATSATSATTLAATAAATAAAAEAGGAASAAAAAKISQVRLTNQATTSMLLLQPNSSFSSLSPFDNFSTQTASTTTTTSASAAGHHQHHNHLLHQQHHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSPQQHLLKSETLLSHEEDQLISNLTDSSVVSHSELFSDLFFPSDSNNSLLSPTTSGYPDNPAEDLTSSIENLTKLTCLRDKRLSSIPEQQLSSEQEQQLCLLSLRSSSDPAIALHAQQQQQQQQQQQQQQQQHQQQQQHLQLQLISPIGGPLSCGSSLPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAAAATVGGPPPVRRASLPVQRTVSPAGSTAQSPKLAKITLNQRHSHAHAHALQLNSAPNSAASSPASADLQAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSPQESPPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTTLPF |
Proteomic databases
Expression
Tissue specificity
Ubiquitously expressed in preblastoderm embryos, specifically in central nervous system and intestinal tract. Highly expressed in third instar larval imaginal disks and brain complexes, but not in ovaries.
Developmental stage
Low levels in 0-8 hours embryos and adults. Higher in late embryogenesis and during larval and pupal stages. Short isoform is enriched in pupae and adults, long isoform in larvae.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 55-81 | Polar residues | ||||
Sequence: NLNAPTHQQSHTSHLQHAQQHQTHQQH | ||||||
Region | 55-87 | Disordered | ||||
Sequence: NLNAPTHQQSHTSHLQHAQQHQTHQQHPLLPPP | ||||||
Region | 150-185 | Disordered | ||||
Sequence: TPAPPATEPRKIKPLGAGKLKVGKTDSNSDSNSNCD | ||||||
Compositional bias | 263-279 | Polar residues | ||||
Sequence: TQTASTTTTTSASAAGH | ||||||
Region | 263-326 | Disordered | ||||
Sequence: TQTASTTTTTSASAAGHHQHHNHLLHQQHHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSP | ||||||
Compositional bias | 290-326 | Polar residues | ||||
Sequence: QHHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSP | ||||||
Region | 437-458 | Disordered | ||||
Sequence: ALHAQQQQQQQQQQQQQQQQHQ | ||||||
Region | 492-514 | Disordered | ||||
Sequence: KYNSSSGSSPQQASSSSTAAPTP | ||||||
Region | 529-579 | Disordered | ||||
Sequence: PPLSGGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGG | ||||||
Compositional bias | 537-579 | Polar residues | ||||
Sequence: ASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGG | ||||||
Region | 618-640 | Disordered | ||||
Sequence: GQQQQQQQQSYQQHNYNSHNGER | ||||||
Zinc finger | 744-764 | NR C4-type | ||||
Sequence: CAVCGDTAACQHYGVRTCEGC | ||||||
Zinc finger | 780-804 | NR C4-type | ||||
Sequence: CLADKNCPVDKRRRNRCQFCRFQKC | ||||||
Region | 819-841 | Disordered | ||||
Sequence: LKGRRGRLPSKPKSPQESPPSPP | ||||||
Domain | 840-1070 | NR LBD | ||||
Sequence: PPISLITALVRSHVDTTPDPSCLDYSHYEEQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTT |
Sequence similarities
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P49869-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameLong
- Length1,073
- Mass (Da)116,992
- Last updated2000-12-01 v3
- Checksum126A30DAFA1C096A
P49869-2
- NameShort
- Differences from canonical
- 1-522: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E1JHM7 | E1JHM7_DROME | Hr38 | 836 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_003714 | 1-522 | in isoform Short | |||
Sequence: Missing | ||||||
Compositional bias | 55-81 | Polar residues | ||||
Sequence: NLNAPTHQQSHTSHLQHAQQHQTHQQH | ||||||
Compositional bias | 263-279 | Polar residues | ||||
Sequence: TQTASTTTTTSASAAGH | ||||||
Compositional bias | 290-326 | Polar residues | ||||
Sequence: QHHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSP | ||||||
Compositional bias | 537-579 | Polar residues | ||||
Sequence: ASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGG | ||||||
Sequence conflict | 667 | in Ref. 4; AAF53914 | ||||
Sequence: V → VSSPSV | ||||||
Sequence conflict | 685 | in Ref. 1 and 3 | ||||
Sequence: S → L | ||||||
Sequence conflict | 689-692 | in Ref. 2; CAA75690 | ||||
Sequence: STAQ → LHGER | ||||||
Sequence conflict | 697 | in Ref. 2; CAA75690 | ||||
Sequence: A → D | ||||||
Sequence conflict | 702 | in Ref. 2; CAA75690 | ||||
Sequence: N → S | ||||||
Sequence conflict | 1041 | in Ref. 2; CAA75690 | ||||
Sequence: S → R | ||||||
Sequence conflict | 1064 | in Ref. 2; CAA75690 | ||||
Sequence: E → D |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X89246 EMBL· GenBank· DDBJ | CAA61534.1 EMBL· GenBank· DDBJ | mRNA | ||
Y15606 EMBL· GenBank· DDBJ | CAA75690.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ002073 EMBL· GenBank· DDBJ | CAA05172.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF53914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U36762 EMBL· GenBank· DDBJ | AAC46926.1 EMBL· GenBank· DDBJ | mRNA |