Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors that may work together to mediate an anti-depressant effect.
Overall methylation levels in the promoter regions of three genes (ALDH1A1 OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity.
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