P49657 · MNB_DROME
- ProteinSerine/threonine-protein kinase minibrain
- Genemnb
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids908 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Role in the specific control of proper proliferation of optic lobe neuronal progeny.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase minibrain
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP49657
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Flies exhibit a specific and marked size reduction of the optic lobes and central brain hemispheres but no major alteration in neuronal architecture can be found.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 191 | in mnb1; reduced brain volume | ||||
Sequence: A → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086340 | 1-908 | Serine/threonine-protein kinase minibrain | |||
Sequence: MYRLEDTNSGGVMDKNKQKLSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGGVGVGVVGQRRHITGPAAQVGISQSVGSGSSGSATGASSSDASSSSPMVGVCVQQNPVVIH |
Proteomic databases
Expression
Tissue specificity
In ventral nerve cord and supraesophageal ganglion of embryos. Is most prominent in the mushroom body neuropil and the outer proliferation center of the optic lobes in third instar larvae.
Developmental stage
Isoform A and isoform C are present mainly in embryos and pupae. By contrast, isoform D appears to be expressed most markedly in third instar larvae and pupae.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P49657 | wap Q9VR53 | 2 | EBI-466373, EBI-92828 | |
BINARY | P49657 | wts Q9VA38 | 3 | EBI-466373, EBI-82717 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-46 | Disordered | ||||
Sequence: MYRLEDTNSGGVMDKNKQKLSAYGSSGGSVDAAQGSGSGGGRQRHA | ||||||
Compositional bias | 11-33 | Polar residues | ||||
Sequence: GVMDKNKQKLSAYGSSGGSVDAA | ||||||
Region | 119-143 | Disordered | ||||
Sequence: KKRRAQQTQGDDDSSNKKERKLYND | ||||||
Motif | 121-139 | Bipartite nuclear localization signal | ||||
Sequence: RRAQQTQGDDDSSNKKERK | ||||||
Domain | 164-484 | Protein kinase | ||||
Sequence: YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF | ||||||
Compositional bias | 552-574 | Polar residues | ||||
Sequence: AAGSSGSGSSVGGGSSAAQQQQA | ||||||
Region | 552-592 | Disordered | ||||
Sequence: AAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPG | ||||||
Region | 623-669 | Disordered | ||||
Sequence: NAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSR | ||||||
Region | 863-895 | Disordered | ||||
Sequence: PAAQVGISQSVGSGSSGSATGASSSDASSSSPM | ||||||
Compositional bias | 865-895 | Polar residues | ||||
Sequence: AQVGISQSVGSGSSGSATGASSSDASSSSPM |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
P49657-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Length908
- Mass (Da)95,903
- Last updated2005-08-16 v2
- ChecksumFFE6841F42F0BAD8
P49657-3
- NameC
P49657-2
- NameD
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-33 | Polar residues | ||||
Sequence: GVMDKNKQKLSAYGSSGGSVDAA | ||||||
Sequence conflict | 45-46 | in Ref. 1; CAA50065/CAA50068/CAA50069 | ||||
Sequence: HA → S | ||||||
Compositional bias | 552-574 | Polar residues | ||||
Sequence: AAGSSGSGSSVGGGSSAAQQQQA | ||||||
Alternative sequence | VSP_004913 | 601-604 | in isoform D | |||
Sequence: GLLM → DDRR | ||||||
Alternative sequence | VSP_004915 | 601-607 | in isoform C | |||
Sequence: GLLMHSV → VRRIVRI | ||||||
Alternative sequence | VSP_004914 | 605-908 | in isoform D | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_004916 | 608-908 | in isoform C | |||
Sequence: Missing | ||||||
Compositional bias | 865-895 | Polar residues | ||||
Sequence: AQVGISQSVGSGSSGSATGASSSDASSSSPM |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X70794 EMBL· GenBank· DDBJ | CAA50065.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
X70798 EMBL· GenBank· DDBJ | CAA50068.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
X70799 EMBL· GenBank· DDBJ | CAA50069.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AE014298 EMBL· GenBank· DDBJ | AAF48777.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAN09442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAX52504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT015255 EMBL· GenBank· DDBJ | AAT94484.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |