P49657 · MNB_DROME

Function

function

Role in the specific control of proper proliferation of optic lobe neuronal progeny.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site170-178ATP (UniProtKB | ChEBI)
Binding site193ATP (UniProtKB | ChEBI)
Binding site243-246ATP (UniProtKB | ChEBI)
Active site292Proton acceptor

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componentterminal bouton
Molecular FunctionATP binding
Molecular Functionprotein kinase inhibitor activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Molecular Functionprotein tyrosine kinase activity
Molecular Functiontranscription coactivator activity
Biological Processcell differentiation
Biological Processcircadian rhythm
Biological Processnegative regulation of cell cycle
Biological Processnegative regulation of hippo signaling
Biological Processnervous system development
Biological Processolfactory learning
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of feeding behavior
Biological Processpositive regulation of growth
Biological Processpositive regulation of neuron differentiation
Biological Processpositive regulation of organ growth
Biological Processpositive regulation of synaptic assembly at neuromuscular junction
Biological Processpositive regulation of synaptic vesicle endocytosis
Biological Processvisual behavior

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase minibrain
  • EC number

Gene names

    • Name
      mnb
    • ORF names
      CG7826

Organism names

  • Taxonomic identifier
  • Strains
    • Berlin
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P49657
  • Secondary accessions
    • Q59E39
    • Q6AWJ3
    • Q9I7R8
    • Q9VX07

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Flies exhibit a specific and marked size reduction of the optic lobes and central brain hemispheres but no major alteration in neuronal architecture can be found.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant191in mnb1; reduced brain volume

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000863401-908Serine/threonine-protein kinase minibrain

Proteomic databases

Expression

Tissue specificity

In ventral nerve cord and supraesophageal ganglion of embryos. Is most prominent in the mushroom body neuropil and the outer proliferation center of the optic lobes in third instar larvae.

Developmental stage

Isoform A and isoform C are present mainly in embryos and pupae. By contrast, isoform D appears to be expressed most markedly in third instar larvae and pupae.

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P49657wap Q9VR532EBI-466373, EBI-92828
BINARY P49657wts Q9VA383EBI-466373, EBI-82717

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

TypeIDPosition(s)Description
Region1-46Disordered
Compositional bias11-33Polar residues
Region119-143Disordered
Motif121-139Bipartite nuclear localization signal
Domain164-484Protein kinase
Compositional bias552-574Polar residues
Region552-592Disordered
Region623-669Disordered
Region863-895Disordered
Compositional bias865-895Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

P49657-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    908
  • Mass (Da)
    95,903
  • Last updated
    2005-08-16 v2
  • Checksum
    FFE6841F42F0BAD8
MYRLEDTNSGGVMDKNKQKLSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGGVGVGVVGQRRHITGPAAQVGISQSVGSGSSGSATGASSSDASSSSPMVGVCVQQNPVVIH

P49657-3

  • Name
    C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P49657-2

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
X2JFM3X2JFM3_DROMEmnb743
Q9VX06Q9VX06_DROMEmnb1047

Sequence caution

The sequence CAA50065.1 differs from that shown. Reason: Frameshift
The sequence CAA50068.1 differs from that shown. Reason: Frameshift
The sequence CAA50069.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias11-33Polar residues
Sequence conflict45-46in Ref. 1; CAA50065/CAA50068/CAA50069
Compositional bias552-574Polar residues
Alternative sequenceVSP_004913601-604in isoform D
Alternative sequenceVSP_004915601-607in isoform C
Alternative sequenceVSP_004914605-908in isoform D
Alternative sequenceVSP_004916608-908in isoform C
Compositional bias865-895Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X70794
EMBL· GenBank· DDBJ
CAA50065.1
EMBL· GenBank· DDBJ
mRNA Frameshift
X70798
EMBL· GenBank· DDBJ
CAA50068.1
EMBL· GenBank· DDBJ
mRNA Frameshift
X70799
EMBL· GenBank· DDBJ
CAA50069.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AE014298
EMBL· GenBank· DDBJ
AAF48777.3
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAN09442.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAX52504.1
EMBL· GenBank· DDBJ
Genomic DNA
BT015255
EMBL· GenBank· DDBJ
AAT94484.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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