P48998 · INVO_RAT
- ProteinInvolucrin
- GeneIvl
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids568 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cornified envelope | |
Cellular Component | cytoplasm | |
Biological Process | keratinization | |
Biological Process | keratinocyte differentiation | |
Biological Process | regulation of antibacterial peptide production | |
Biological Process | response to UV-B |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameInvolucrin
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP48998
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Constituent of the scaffolding of the cornified envelope.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000159743 | 1-568 | Involucrin | |||
Sequence: MSHQHTVPVTVPAVVQESLKTVCSPAQTQQEQTKQPTPYPAQCQVFTDTQEKGFPKHEEKEANPVKDLPEQESEHHQQPGPQKQQLQVKKPEQELQEQELHSEKQPQEPQGLLCLGQQQQREPQEQEQHLRQHQQPQQESQGQGLCLGQQQDVLAPQELHMGQHQKEKLQEPELPLGQQQKTPEEQELILGEKQQKLHLVERHQEPQEQELHHGQKQKQQQPQEQELQLVQHQKQKQHEPELCLRKQQQQESHERELHLGKQQQQESHEPELHLGKQQHQESHEPELHLGKQQHQESCEPELHLGEQQHQEQQQHQESCEPELHLGKQQHQETQESELQLGKQQKPHEPDMVLDPKEKQKLHDPELHLGKQQHQESQESELQVEKKQHEKSPEPELHLGKQQELHEPDMTEDQKEKQSLHEPELHLGKQQESHEPDMTEDQKEKQSLYEPELHLGKQQEQQIEYEGYQRSKSLNQLLKQEKASRGQELDDSHLEQEKELLDQRLDQELVNKDEQLERKKHKLENLTQKEKQIKQLVPSTDRVQETQPIQPVKEDSLTTKKQQHSHEVQ | ||||||
Modified residue | 472 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Keratinocytes of epidermis and other stratified squamous epithelia.
Interaction
Subunit
Directly or indirectly cross-linked to cornifelin (CNFN).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-49 | Polar residues | ||||
Sequence: CSPAQTQQEQTKQPTPYPAQCQVFTDT | ||||||
Region | 23-499 | Disordered | ||||
Sequence: CSPAQTQQEQTKQPTPYPAQCQVFTDTQEKGFPKHEEKEANPVKDLPEQESEHHQQPGPQKQQLQVKKPEQELQEQELHSEKQPQEPQGLLCLGQQQQREPQEQEQHLRQHQQPQQESQGQGLCLGQQQDVLAPQELHMGQHQKEKLQEPELPLGQQQKTPEEQELILGEKQQKLHLVERHQEPQEQELHHGQKQKQQQPQEQELQLVQHQKQKQHEPELCLRKQQQQESHERELHLGKQQQQESHEPELHLGKQQHQESHEPELHLGKQQHQESCEPELHLGEQQHQEQQQHQESCEPELHLGKQQHQETQESELQLGKQQKPHEPDMVLDPKEKQKLHDPELHLGKQQHQESQESELQVEKKQHEKSPEPELHLGKQQELHEPDMTEDQKEKQSLHEPELHLGKQQESHEPDMTEDQKEKQSLYEPELHLGKQQEQQIEYEGYQRSKSLNQLLKQEKASRGQELDDSHLEQEKEL | ||||||
Compositional bias | 51-77 | Basic and acidic residues | ||||
Sequence: EKGFPKHEEKEANPVKDLPEQESEHHQ | ||||||
Compositional bias | 90-104 | Basic and acidic residues | ||||
Sequence: KPEQELQEQELHSEK | ||||||
Compositional bias | 130-150 | Polar residues | ||||
Sequence: LRQHQQPQQESQGQGLCLGQQ | ||||||
Compositional bias | 186-219 | Basic and acidic residues | ||||
Sequence: QELILGEKQQKLHLVERHQEPQEQELHHGQKQKQ | ||||||
Compositional bias | 231-331 | Basic and acidic residues | ||||
Sequence: QHQKQKQHEPELCLRKQQQQESHERELHLGKQQQQESHEPELHLGKQQHQESHEPELHLGKQQHQESCEPELHLGEQQHQEQQQHQESCEPELHLGKQQHQ | ||||||
Compositional bias | 341-450 | Basic and acidic residues | ||||
Sequence: GKQQKPHEPDMVLDPKEKQKLHDPELHLGKQQHQESQESELQVEKKQHEKSPEPELHLGKQQELHEPDMTEDQKEKQSLHEPELHLGKQQESHEPDMTEDQKEKQSLYEP | ||||||
Compositional bias | 461-481 | Polar residues | ||||
Sequence: QIEYEGYQRSKSLNQLLKQEK | ||||||
Compositional bias | 482-499 | Basic and acidic residues | ||||
Sequence: ASRGQELDDSHLEQEKEL | ||||||
Region | 517-568 | Disordered | ||||
Sequence: RKKHKLENLTQKEKQIKQLVPSTDRVQETQPIQPVKEDSLTTKKQQHSHEVQ | ||||||
Compositional bias | 529-555 | Polar residues | ||||
Sequence: EKQIKQLVPSTDRVQETQPIQPVKEDS |
Sequence similarities
Belongs to the involucrin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length568
- Mass (Da)67,021
- Last updated1996-02-01 v1
- ChecksumE2B07740FE779345
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1LPF7 | F1LPF7_RAT | Ivl | 578 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-49 | Polar residues | ||||
Sequence: CSPAQTQQEQTKQPTPYPAQCQVFTDT | ||||||
Compositional bias | 51-77 | Basic and acidic residues | ||||
Sequence: EKGFPKHEEKEANPVKDLPEQESEHHQ | ||||||
Compositional bias | 90-104 | Basic and acidic residues | ||||
Sequence: KPEQELQEQELHSEK | ||||||
Compositional bias | 130-150 | Polar residues | ||||
Sequence: LRQHQQPQQESQGQGLCLGQQ | ||||||
Compositional bias | 186-219 | Basic and acidic residues | ||||
Sequence: QELILGEKQQKLHLVERHQEPQEQELHHGQKQKQ | ||||||
Compositional bias | 231-331 | Basic and acidic residues | ||||
Sequence: QHQKQKQHEPELCLRKQQQQESHERELHLGKQQQQESHEPELHLGKQQHQESHEPELHLGKQQHQESCEPELHLGEQQHQEQQQHQESCEPELHLGKQQHQ | ||||||
Compositional bias | 341-450 | Basic and acidic residues | ||||
Sequence: GKQQKPHEPDMVLDPKEKQKLHDPELHLGKQQHQESQESELQVEKKQHEKSPEPELHLGKQQELHEPDMTEDQKEKQSLHEPELHLGKQQESHEPDMTEDQKEKQSLYEP | ||||||
Compositional bias | 461-481 | Polar residues | ||||
Sequence: QIEYEGYQRSKSLNQLLKQEK | ||||||
Compositional bias | 482-499 | Basic and acidic residues | ||||
Sequence: ASRGQELDDSHLEQEKEL | ||||||
Compositional bias | 529-555 | Polar residues | ||||
Sequence: EKQIKQLVPSTDRVQETQPIQPVKEDS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L28818 EMBL· GenBank· DDBJ | AAA41445.1 EMBL· GenBank· DDBJ | Genomic DNA |