Structure and regulation of the mouse cardiac troponin I gene.Ausoni S., Campione M., Picard A., Moretti P., Vittadello M., de Nardi C., Schiaffino S.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 269:339-346 (1994)Cited in1Mapped to4
Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation.Guo X., Wattanapermpool J., Palmiter K.A., Murphy A.M., Solaro R.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]StrainCD-1TissueHeartCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 269:15210-15216 (1994)Cited in1Mapped to4
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueHeartCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation.Scruggs S.B., Walker L.A., Lyu T., Geenen D.L., Solaro R.J., Buttrick P.M., Goldspink P.H.View abstractCited forPHOSPHORYLATION AT SER-43 AND SER-45CategoryPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Mol. Cell. Cardiol. 40:465-473 (2006)Cited in2Mapped to2
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueHeartCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin.Howarth J.W., Meller J., Solaro R.J., Trewhella J., Rosevear P.R.View abstractCited forSTRUCTURE BY NMR OF 1-32, PHOSPHORYLATION AT SER-23 AND SER-24CategoriesPTM / Processing, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Mol. Biol. 373:706-722 (2007)Cited in1Mapped to1
Cardiac troponin I gene knockout: a mouse model of myocardial troponin I deficiency.Huang X., Pi Y., Lee K.J., Henkel A.S., Gregg R.G., Powers P.A., Walker J.W.View abstractAnnotationKnockout mice lacking cTnI (Tnni3) die of acute heart failure at P18 displaying shortened sarcomeres.CategoryPhenotypes & VariantsSourceGeneRif: 21954, MGI: 98783PubMedEurope PMCCirc Res 84:1-8 (1999)Mapped to10
Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo.Di Lisi R., Millino C., Calabria E., Altruda F., Schiaffino S., Ausoni S.View abstractCategoryExpressionSourceMGI: 98783PubMedEurope PMCJ Biol Chem 273:25371-25380 (1998)Mapped to71
Developmentally regulated muscle type-specific alternative splicing of the COOH-terminal variable region of fast skeletal muscle troponin T and an aberrant splicing pathway to encode a mutant COOH-terminus.Jin J.P., Wang J., Ogut O.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCBiochem Biophys Res Commun 242:540-544 (1998)Mapped to5
Tissue-specific alternative splicing of ascidian troponin I isoforms. Redesign of a protein isoform-generating mechanism during chordate evolution.MacLean D.W., Meedel T.H., Hastings K.E.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCJ Biol Chem 272:32115-32120 (1997)Cited in4Mapped to13
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy.Kimura A., Harada H., Park J.-E., Nishi H., Satoh M., Takahashi M., Hiroi S., Sasaoka T., Ohbuchi N.[...], Sasazuki T.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCNat. Genet. 16:379-382 (1997)Cited in1Mapped to5
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M.View abstractCategoryFunctionSourceMGI: 98783PubMedEurope PMCGenes Dev 11:1048-1060 (1997)Mapped to62
Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7.Guenet J.L., Simon-Chazottes D., Gravel M., Hastings K.E., Schiaffino S.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCMamm Genome 7:13-15 (1996)Mapped to65
Mapping TNNC1, the gene that encodes cardiac troponin I in the human and the mouse.Bermingham N., Hernandez D., Balfour A., Gilmour F., Martin J.E., Fisher E.M.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCGenomics 30:620-622 (1995)Mapped to9
Strong evolutionary conservation of broadly expressed protein isoforms in the troponin I gene family and other vertebrate gene families.Hastings K.E.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCJ Mol Evol 42:631-640 (1996)Cited in1Mapped to5
Isolation and characterization of the human cardiac troponin I gene (TNNI3).Bhavsar P.K., Brand N.J., Yacoub M.H., Barton P.J.R.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCGenomics 35:11-23 (1996)Cited in1Mapped to5
Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.Chen Z., Friedrich G.A., Soriano P.View abstractCategorySequencesSourceMGI: 98783PubMedEurope PMCGenes Dev. 8:2293-2301 (1994)Cited in1Mapped to37
Developmental regulation of troponin I isoform genes in striated muscles of transgenic mice.Zhu L., Lyons G.E., Juhasz O., Joya J.E., Hardeman E.C., Wade R.View abstractCategoriesSequences, ExpressionSourceMGI: 98783PubMedEurope PMCDev Biol 169:487-503 (1995)Mapped to13
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.Lyons I., Parsons L.M., Hartley L., Li R., Andrews J.E., Robb L., Harvey R.P.View abstractCategoryExpressionSourceMGI: 98783PubMedEurope PMCGenes Dev 9:1654-1666 (1995)Mapped to99+
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1.Noland T.A. Jr., Guo X., Raynor R.L., Jideama N.M., Averyhart-Fullard V., Solaro R.J., Kuo J.F.View abstractCategoryPTM / ProcessingSourcePhosphoSitePlus: P48787PubMedEurope PMCJ Biol Chem 270:25445-25454 (1995)Mapped to1
ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.Mah S.Y.Y., Vanyai H.K., Li-Wai-Suen C.S.N., Garnham A.L., Wynn J., Bergamasco M.I., Malelang S., Wilcox S., Biben C.[...], Voss A.K.View abstractCategoryFunctionSourceMGI: 98783PubMedEurope PMCDevelopment 151:dev202617-dev202617 (2024)Mapped to40
Coordinated metabolic responses to cyclophilin D deletion in the developing heart.Beutner G., Burris J.R., Collins M.P., Kulkarni C.A., Nadtochiy S.M., de Mesy Bentley K.L., Cohen E.D., Brookes P.S., Porter G.A. Jr.View abstractCategoryFunctionSourceMGI: 98783PubMedEurope PMCiScience 27:109157-109157 (2024)Mapped to69
Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes.Li C., Zhang Y., Shen J., Bao H., Zhao Y., Li D., Li S., Liu Y., Yang J.[...], Cai B.View abstractCategoryFunctionSourceMGI: 98783PubMedEurope PMCAdv Sci (Weinh) 11:e2305992-e2305992 (2024)Mapped to99+
eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling.Eley L., Richardson R.V., Alqahtani A., Chaudhry B., Henderson D.J.View abstractCategoryFunctionSourceMGI: 98783PubMedEurope PMCDis Model Mech 17:dmm050265-dmm050265 (2024)Mapped to99+
Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function.Salyer L.G., Salhi H.E., Brundage E.A., Shettigar V., Sturgill S.L., Zanella H., Templeton B., Abay E., Emmer K.M.[...], Biesiadecki B.J.View abstractAnnotationTroponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function.CategoryFunctionSourceGeneRif: 21954PubMedEurope PMCCirc Res 134:33-45 (2024)Mapped to3