P48642 · GSHRC_ORYSJ
- ProteinGlutathione reductase, cytosolic
- GeneGRC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids496 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Maintains high levels of reduced glutathione in the cytosol.
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- 2 glutathione + NADP+ = glutathione disulfide + H+ + NADPH
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | glutathione-disulfide reductase (NADPH) activity | |
Molecular Function | NADP binding | |
Molecular Function | thioredoxin-disulfide reductase (NADPH) activity | |
Biological Process | cell redox homeostasis | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione reductase, cytosolic
- EC number
- Short namesGR; GRase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionP48642
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, disulfide bond, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000067963 | 1-496 | UniProt | Glutathione reductase, cytosolic | |||
Sequence: MARKMLKDEEVEVAVTDGGSYDYDLFVIGAGSGGVRGSRTSASFGAKVAICELPFHPISSDWQGGHGGTCVIRGCVPKKILVYGSSFRGEFEDAKNFGWEINGDINFNWKRLLENKTQEIVRLNGVYQRILGNSGVTMIEGAGSLVDAHTVEVTKPDGSKQRYTAKHILIATGSRAQRVNIPGKELAITSDEALSLEELPKRAVILGGGYIAVEFASIWKGMGAHVDLFYRKELPLRGFDDEMRTVVASNLEGRGIRLHPGTNLSELSKTADGIKVVTDKGEEIIADVVLFATGRTPNSQRLNLEAAGVEVDNIGAIKVDDYSRTSVPNIWAVGDVTNRINLTPVALMEATCFSKTVFGGQPTKPDYRDVPCAVFSIPPLSVVGLSEQQALEEAKSDVLVYTSSFNPMKNSISKRQEKTVMKLVVDSETDKVLGASMCGPDAPEIIQGMAVALKCGATKATFDSTVGIHPSAAEEFVTMRTLTRRVSPSSKPKTNL | |||||||
Disulfide bond | 70↔75 | UniProt | Redox-active | ||||
Sequence: CVIRGC | |||||||
Modified residue (large scale data) | 86 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 487 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length496
- Mass (Da)53,507
- Last updated2001-09-26 v2
- ChecksumA27FEE5D847F97F6
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0P0VR27 | A0A0P0VR27_ORYSJ | Os02g0813500 | 190 | ||
A0A0P0VR44 | A0A0P0VR44_ORYSJ | Os02g0813500 | 159 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 31 | in Ref. 1; BAA11214 | ||||
Sequence: G → V | ||||||
Sequence conflict | 48 | in Ref. 1; BAA11214 | ||||
Sequence: V → F | ||||||
Sequence conflict | 97 | in Ref. 1; BAA11214 | ||||
Sequence: F → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D78136 EMBL· GenBank· DDBJ | BAA11214.1 EMBL· GenBank· DDBJ | mRNA | ||
D85751 EMBL· GenBank· DDBJ | BAA36283.1 EMBL· GenBank· DDBJ | mRNA | ||
AB009592 EMBL· GenBank· DDBJ | BAA37092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP004120 EMBL· GenBank· DDBJ | BAD21653.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP005691 EMBL· GenBank· DDBJ | BAD22392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008208 EMBL· GenBank· DDBJ | BAF10399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014958 EMBL· GenBank· DDBJ | BAS81540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000139 EMBL· GenBank· DDBJ | EAZ25050.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136760 EMBL· GenBank· DDBJ | AAN15933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136761 EMBL· GenBank· DDBJ | AAN15934.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136762 EMBL· GenBank· DDBJ | AAN15935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136763 EMBL· GenBank· DDBJ | AAN15936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136764 EMBL· GenBank· DDBJ | AAN15937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136765 EMBL· GenBank· DDBJ | AAN15938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY136766 EMBL· GenBank· DDBJ | AAN15939.1 EMBL· GenBank· DDBJ | Genomic DNA |