P48614 · WN10B_MOUSE

  • Protein
    Protein Wnt-10b
  • Gene
    Wnt10b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionsignaling receptor binding
Biological Processanimal organ morphogenesis
Biological Processbone trabecula formation
Biological Processcanonical Wnt signaling pathway
Biological Processcell population proliferation
Biological Processcell-cell signaling
Biological Processcellular response to cAMP
Biological Processcellular response to organic cyclic compound
Biological Processcellular response to parathyroid hormone stimulus
Biological Processchondrocyte differentiation
Biological Processepithelial cell differentiation
Biological Processfat cell differentiation
Biological Processfungiform papilla development
Biological ProcessG2/M transition of mitotic cell cycle
Biological Processhematopoietic stem cell proliferation
Biological Processlipid metabolic process
Biological Processmyoblast development
Biological Processmyoblast differentiation involved in skeletal muscle regeneration
Biological Processnegative regulation of cold-induced thermogenesis
Biological Processnegative regulation of epithelial cell proliferation
Biological Processnegative regulation of fat cell differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processosteoblast differentiation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of bone mineralization
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processpositive regulation of epithelial cell differentiation
Biological Processpositive regulation of G2/M transition of mitotic cell cycle
Biological Processpositive regulation of hematopoietic stem cell proliferation
Biological Processpositive regulation of ossification
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Processpositive regulation of T cell differentiation
Biological Processpositive regulation of timing of anagen
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein stabilization
Biological Processregulation of cell cycle
Biological Processregulation of fat cell differentiation
Biological Processregulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processregulation of protein metabolic process
Biological Processregulation of skeletal muscle tissue development
Biological Processregulation of transcription by RNA polymerase II
Biological Processsensory perception of taste
Biological Processsignal transduction
Biological Processskeletal muscle fiber development
Biological Processskeletal muscle tissue regeneration
Biological Processsmoothened signaling pathway
Biological ProcessT cell differentiation
Biological Processtranscription by RNA polymerase II
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Wnt-10b
  • Alternative names
    • Protein Wnt-12

Gene names

    • Name
      Wnt10b
    • Synonyms
      Wnt-10b, Wnt10, Wnt12

Organism names

  • Taxonomic identifier
  • Strain
    • Swiss Webster
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P48614
  • Secondary accessions
    • P70702

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, modified residue, disulfide bond, glycosylation, lipidation.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_000004146429-389Protein Wnt-10b
Modified residue46Phosphothreonine
Disulfide bond83↔94
Glycosylation93N-linked (GlcNAc...) asparagine
Disulfide bond136↔144
Disulfide bond146↔199
Disulfide bond247↔261
Disulfide bond249↔256
Lipidation253O-palmitoleoyl serine; by PORCN
Disulfide bond318↔349
Disulfide bond334↔344
Glycosylation335N-linked (GlcNAc...) asparagine
Disulfide bond348↔388
Disulfide bond364↔379
Disulfide bond366↔376
Disulfide bond371↔372

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in embryos and in the mammary gland of non-pregnant mice.

Gene expression databases

Interaction

Subunit

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids.

Protein-protein interaction databases

Miscellaneous

Structure

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P48614-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    389
  • Mass (Da)
    43,119
  • Last updated
    1996-02-01 v1
  • MD5 Checksum
    5FE40D50927ABA32E6C604A09F19312C
MLEEPRSRPPPLGLAGLLFLALFSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKTFPISQPSPVPGSVPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAIGAALRERLSRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTLGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK

P48614-2

  • Name
    Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I3BQZ8A0A2I3BQZ8_MOUSEWnt10b171
Q1RME7Q1RME7_MOUSEWnt10b173

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_006796143-238in isoform Short

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U20658
EMBL· GenBank· DDBJ
AAA80110.1
EMBL· GenBank· DDBJ
mRNA
U30464
EMBL· GenBank· DDBJ
AAA84399.1
EMBL· GenBank· DDBJ
mRNA
U61970
EMBL· GenBank· DDBJ
AAB08086.1
EMBL· GenBank· DDBJ
mRNA
U61971
EMBL· GenBank· DDBJ
AAB08087.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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