P48558 · BXI1_YEAST

Function

function

Links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis (PubMed:21673659, PubMed:21673967).
Induces cell death and disruption of the mitochondrial transmembrane potential via the mitochondrial phosphate carrier MIR1 (PubMed:21673659).
Dispensible for starvation-induced autophagy (PubMed:21926971).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentfungal-type vacuole
Cellular Componentmembrane
Cellular Componentmitochondrial membrane
Cellular Componentmitochondrion
Cellular Componentvacuolar membrane
Biological Processapoptotic process
Biological Processcalcium-mediated signaling
Biological Processendoplasmic reticulum unfolded protein response

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 1.A.14.3.5the calcium transporter a (cata) family (formerly the testis-enhanced gene transfer (tegt) family)

Names & Taxonomy

Protein names

  • Recommended name
    Bax inhibitor 1
  • Alternative names
    • BH3 domain-containing protein BXI1

Gene names

    • Name
      BXI1
    • Synonyms
      YBH3
    • ORF names
      N0405
    • Ordered locus names
      YNL305C

Organism names

Accessions

  • Primary accession
    P48558
  • Secondary accessions
    • D6W0P0
    • Q6B2Q1

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Vacuole membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Note: Translocated from predominantly vacuolar sites in healthy cells to mitochondria upon apoptosis induction.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-53Lumenal
Transmembrane54-74Helical
Topological domain75-85Cytoplasmic
Transmembrane86-106Helical
Topological domain107-146Lumenal
Transmembrane147-167Helical
Topological domain168-171Cytoplasmic
Transmembrane172-192Helical
Topological domain193-208Lumenal
Transmembrane209-229Helical
Topological domain230-239Cytoplasmic
Transmembrane240-260Helical
Topological domain261-270Lumenal
Transmembrane271-291Helical
Topological domain292-297Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

No effect on autophagy during nitrogen starvation.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002033691-297Bax inhibitor 1

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P48558YOL075C Q082342EBI-28349, EBI-29278

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    33,645
  • Last updated
    1996-02-01 v1
  • Checksum
    330784DA17152BB0
MSGPPPPYEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVISCEPIIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIWLAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFRKVYPDEEVRCAMMLYLDIVNLFLSILRILANSNDDN

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict84in Ref. 4; AAT92698

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U23084
EMBL· GenBank· DDBJ
AAC49093.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71581
EMBL· GenBank· DDBJ
CAA96233.1
EMBL· GenBank· DDBJ
Genomic DNA
AY692679
EMBL· GenBank· DDBJ
AAT92698.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006947
EMBL· GenBank· DDBJ
DAA10256.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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