P48545 · KCNJ5_MOUSE

  • Protein
    G protein-activated inward rectifier potassium channel 4
  • Gene
    Kcnj5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Features

Showing features for site.

141950100150200250300350400
TypeIDPosition(s)Description
Site179Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular ComponentI(KACh) inward rectifier potassium channel complex
Cellular Componentplasma membrane
Cellular ComponentT-tubule
Molecular FunctionG-protein activated inward rectifier potassium channel activity
Molecular Functioninward rectifier potassium channel activity
Molecular Functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
Biological Processmembrane repolarization during atrial cardiac muscle cell action potential
Biological Processpotassium ion import across plasma membrane
Biological Processpotassium ion transmembrane transport
Biological Processregulation of heart rate by cardiac conduction
Biological Processregulation of monoatomic ion transmembrane transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    G protein-activated inward rectifier potassium channel 4
  • Short names
    GIRK-4
  • Alternative names
    • Cardiac inward rectifier (CIR)
    • Heart KATP channel
    • Inward rectifier K(+) channel Kir3.4
    • KATP-1
    • Potassium channel, inwardly rectifying subfamily J member 5

Gene names

    • Name
      Kcnj5
    • Synonyms
      Girk4

Organism names

  • Taxonomic identifier
  • Strains
    • 129/SvJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P48545
  • Secondary accessions
    • P97508
    • Q3TPX9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-86Cytoplasmic
Transmembrane87-111Helical; Name=M1
Topological domain112-135Extracellular
Intramembrane136-147Helical; Pore-forming; Name=H5
Intramembrane148-154Pore-forming
Topological domain155-163Extracellular
Transmembrane164-185Helical; Name=M2
Topological domain186-419Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001549351-419G protein-activated inward rectifier potassium channel 4
Modified residue5Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominantly atrial and pancreatic expression.

Gene expression databases

Interaction

Subunit

May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.
View interactors in UniProtKB
View CPX-3277 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for motif, region.

TypeIDPosition(s)Description
Motif149-154Selectivity filter
Region388-419Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    47,669
  • Last updated
    2011-07-27 v3
  • Checksum
    8383373921C7356A
MAGDSRNAMNQDMEIGVTSQDHKKIPKQARDYIPIATDRTRLLTEGKKPRQRYMEKTGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSRAQLEQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKRSGRLLQYLPSPPLLGGCAEAGNEAEAEKDEEGEPNGLSVSQATRGSM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1L1SRH1A0A1L1SRH1_MOUSEKcnj5106

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict102in Ref. 1; AAB01687
Sequence conflict109in Ref. 1; AAB01687
Sequence conflict172in Ref. 2; AAC53116
Sequence conflict193in Ref. 1; AAB01687
Sequence conflict214in Ref. 2; AAC53116
Sequence conflict232in Ref. 1; AAB01687
Sequence conflict269in Ref. 1; AAB01687
Sequence conflict287in Ref. 1; AAB01687
Sequence conflict296in Ref. 2; AAC53116
Sequence conflict351in Ref. 2; AAC53116

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U33631
EMBL· GenBank· DDBJ
AAB01687.1
EMBL· GenBank· DDBJ
mRNA
AF403131
EMBL· GenBank· DDBJ
AAC53116.1
EMBL· GenBank· DDBJ
Genomic DNA
AK164058
EMBL· GenBank· DDBJ
BAE37606.1
EMBL· GenBank· DDBJ
mRNA
CH466522
EMBL· GenBank· DDBJ
EDL25354.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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