P48542 · KCNJ6_MOUSE

  • Protein
    G protein-activated inward rectifier potassium channel 2
  • Gene
    Kcnj6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation, possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Features

Showing features for site.

142550100150200250300350400
TypeIDPosition(s)Description
Site184Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcell surface
Cellular Componentdendrite
Cellular Componentmonoatomic ion channel complex
Cellular Componentneuronal cell body membrane
Cellular Componentparallel fiber to Purkinje cell synapse
Cellular Componentplasma membrane
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentpresynaptic membrane
Molecular FunctionG-protein activated inward rectifier potassium channel activity
Molecular FunctionG-protein alpha-subunit binding
Molecular Functioninward rectifier potassium channel activity
Molecular Functionpotassium channel activity
Molecular Functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Biological Processnegative regulation of insulin secretion
Biological Processpotassium ion import across plasma membrane
Biological Processregulation of monoatomic ion transmembrane transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    G protein-activated inward rectifier potassium channel 2
  • Short names
    GIRK-2
  • Alternative names
    • Inward rectifier K(+) channel Kir3.2
    • Potassium channel, inwardly rectifying subfamily J member 6

Gene names

    • Name
      Kcnj6
    • Synonyms
      Girk2, Kcnj7, W

Organism names

  • Taxonomic identifier
  • Strains
    • 129/SvJ
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P48542
  • Secondary accessions
    • O70290
    • P70216
    • P70306
    • P70307
    • P70308

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-91Cytoplasmic
Transmembrane92-116Helical; Name=M1
Topological domain117-140Extracellular
Intramembrane141-152Helical; Pore-forming; Name=H5
Intramembrane153-159Pore-forming
Topological domain160-168Extracellular
Transmembrane169-190Helical; Name=M2
Topological domain191-425Cytoplasmic

Keywords

Phenotypes & Variants

Involvement in disease

  • Defects in Kcnj6 are the cause of the weaver (wv) phenotype. Homozygous animals suffer from severe ataxia that is obvious by about the second postnatal week. The cerebellum of these animals is drastically reduced in size due to depletion of the major cell type of cerebellum, the granule cell neuron. Heterozygous animals are not ataxic but have an intermediate number of surviving granule cells. Male homozygotes are sterile, because of complete failure of sperm production. Both hetero- and homozygous animals undergo sporadic tonic-clonic seizures

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant156in wv
Natural variant313
Natural variant344

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Chemistry

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001549441-425G protein-activated inward rectifier potassium channel 2
Modified residue18Phosphoserine
Modified residue25Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Cerebellum, testes, cortex and substentia nigra.

Interaction

Subunit

May associate with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for motif, region, compositional bias.

TypeIDPosition(s)Description
Motif154-159Selectivity filter
Region392-425Disordered
Compositional bias394-425Basic and acidic residues
Motif422-425PDZ-binding

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

P48542-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    GIRK2A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    425
  • Mass (Da)
    48,652
  • Last updated
    1996-02-01 v1
  • Checksum
    2E5153DCB1B60331
MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQSDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGIVEATGMTCQARSSYITSEILWGYRFTPVLTMEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAEVPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV

P48542-2

  • Name
    GIRK2-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P48542-3

  • Name
    GIRK2B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P48542-4

P48542-5

  • Name
    GIRK2D
  • Synonyms
    KIR3.2D
  • See also
    sequence in UniParc or sequence clusters in UniRef

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A338P6L0A0A338P6L0_MOUSEKcnj6407
A0A0R4J239A0A0R4J239_MOUSEKcnj6302
Q8C4T8Q8C4T8_MOUSEKcnj6414
Q0VB45Q0VB45_MOUSEKcnj6425

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0028061-18in isoform GIRK2C
Sequence conflict67in Ref. 3 and 4
Sequence conflict260in Ref. 3; BAA12972, 4; AAC34145 and 5; BAA88430
Alternative sequenceVSP_002807319-320in isoform GIRK2C
Alternative sequenceVSP_002804319-327in isoform GIRK2B
Alternative sequenceVSP_002808321-425in isoform GIRK2C
Alternative sequenceVSP_002805328-425in isoform GIRK2B
Sequence conflict381in Ref. 5; BAA88430
Compositional bias394-425Basic and acidic residues
Alternative sequenceVSP_002803415-425in isoform GIRK2-1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U37253
EMBL· GenBank· DDBJ
AAA91457.1
EMBL· GenBank· DDBJ
mRNA
U11859
EMBL· GenBank· DDBJ
AAA53245.1
EMBL· GenBank· DDBJ
mRNA
U51122
EMBL· GenBank· DDBJ
AAC34141.1
EMBL· GenBank· DDBJ
mRNA
U51123
EMBL· GenBank· DDBJ
AAC34142.1
EMBL· GenBank· DDBJ
mRNA
U51124
EMBL· GenBank· DDBJ
AAC34143.1
EMBL· GenBank· DDBJ
mRNA
U51125
EMBL· GenBank· DDBJ
AAC34144.1
EMBL· GenBank· DDBJ
mRNA
U51126
EMBL· GenBank· DDBJ
AAC34145.1
EMBL· GenBank· DDBJ
mRNA
AF040049
EMBL· GenBank· DDBJ
AAC34286.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040047
EMBL· GenBank· DDBJ
AAC34286.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040050
EMBL· GenBank· DDBJ
AAC34287.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040049
EMBL· GenBank· DDBJ
AAC34287.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040051
EMBL· GenBank· DDBJ
AAC34285.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040047
EMBL· GenBank· DDBJ
AAC34285.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040049
EMBL· GenBank· DDBJ
AAC34285.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040052
EMBL· GenBank· DDBJ
AAC34284.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040047
EMBL· GenBank· DDBJ
AAC34284.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040049
EMBL· GenBank· DDBJ
AAC34284.1
EMBL· GenBank· DDBJ
Genomic DNA
AF040051
EMBL· GenBank· DDBJ
AAC34284.1
EMBL· GenBank· DDBJ
Genomic DNA
D86040
EMBL· GenBank· DDBJ
BAA12972.1
EMBL· GenBank· DDBJ
mRNA
AB029502
EMBL· GenBank· DDBJ
BAA88430.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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