P48542 · KCNJ6_MOUSE
- ProteinG protein-activated inward rectifier potassium channel 2
- GeneKcnj6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids425 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 184 | Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium | ||||
Sequence: N |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cell surface | |
Cellular Component | dendrite | |
Cellular Component | monoatomic ion channel complex | |
Cellular Component | neuronal cell body membrane | |
Cellular Component | parallel fiber to Purkinje cell synapse | |
Cellular Component | plasma membrane | |
Cellular Component | postsynapse | |
Cellular Component | presynapse | |
Cellular Component | presynaptic membrane | |
Molecular Function | G-protein activated inward rectifier potassium channel activity | |
Molecular Function | G-protein alpha-subunit binding | |
Molecular Function | inward rectifier potassium channel activity | |
Molecular Function | potassium channel activity | |
Molecular Function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | |
Biological Process | negative regulation of insulin secretion | |
Biological Process | potassium ion import across plasma membrane | |
Biological Process | regulation of monoatomic ion transmembrane transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameG protein-activated inward rectifier potassium channel 2
- Short namesGIRK-2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP48542
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-91 | Cytoplasmic | ||||
Sequence: MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKW | ||||||
Transmembrane | 92-116 | Helical; Name=M1 | ||||
Sequence: RFNLLIFVMVYTVTWLFFGMIWWLI | ||||||
Topological domain | 117-140 | Extracellular | ||||
Sequence: AYIRGDMDHIEDPSWTPCVTNLNG | ||||||
Intramembrane | 141-152 | Helical; Pore-forming; Name=H5 | ||||
Sequence: FVSAFLFSIETE | ||||||
Intramembrane | 153-159 | Pore-forming | ||||
Sequence: TTIGYGY | ||||||
Topological domain | 160-168 | Extracellular | ||||
Sequence: RVITDKCPE | ||||||
Transmembrane | 169-190 | Helical; Name=M2 | ||||
Sequence: GIILLLIQSVLGSIVNAFMVGC | ||||||
Topological domain | 191-425 | Cytoplasmic | ||||
Sequence: MFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQSDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGIVEATGMTCQARSSYITSEILWGYRFTPVLTMEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAEVPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV |
Keywords
- Cellular component
Phenotypes & Variants
Involvement in disease
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 156 | in wv | ||||
Sequence: G → S | ||||||
Natural variant | 313 | |||||
Sequence: I → M | ||||||
Natural variant | 344 | |||||
Sequence: M → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Chemistry
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000154944 | 1-425 | G protein-activated inward rectifier potassium channel 2 | |||
Sequence: MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQSDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGIVEATGMTCQARSSYITSEILWGYRFTPVLTMEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAEVPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV | ||||||
Modified residue | 18 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 25 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Interaction
Subunit
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 154-159 | Selectivity filter | ||||
Sequence: TIGYGY | ||||||
Region | 392-425 | Disordered | ||||
Sequence: NQHAELETEEEEKNPEELTERNGDVANLENESKV | ||||||
Compositional bias | 394-425 | Basic and acidic residues | ||||
Sequence: HAELETEEEEKNPEELTERNGDVANLENESKV | ||||||
Motif | 422-425 | PDZ-binding | ||||
Sequence: ESKV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
P48542-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameGIRK2A
- Length425
- Mass (Da)48,652
- Last updated1996-02-01 v1
- Checksum2E5153DCB1B60331
P48542-2
- NameGIRK2-1
- Differences from canonical
- 415-425: Missing
P48542-3
- NameGIRK2B
P48542-4
- NameGIRK2C
P48542-5
- NameGIRK2D
- SynonymsKIR3.2D
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A338P6L0 | A0A338P6L0_MOUSE | Kcnj6 | 407 | ||
A0A0R4J239 | A0A0R4J239_MOUSE | Kcnj6 | 302 | ||
Q8C4T8 | Q8C4T8_MOUSE | Kcnj6 | 414 | ||
Q0VB45 | Q0VB45_MOUSE | Kcnj6 | 425 |
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_002806 | 1-18 | in isoform GIRK2C | |||
Sequence: Missing | ||||||
Sequence conflict | 67 | in Ref. 3 and 4 | ||||
Sequence: V → C | ||||||
Sequence conflict | 260 | in Ref. 3; BAA12972, 4; AAC34145 and 5; BAA88430 | ||||
Sequence: S → T | ||||||
Alternative sequence | VSP_002807 | 319-320 | in isoform GIRK2C | |||
Sequence: MT → QF | ||||||
Alternative sequence | VSP_002804 | 319-327 | in isoform GIRK2B | |||
Sequence: MTCQARSSY → KMGFALGFL | ||||||
Alternative sequence | VSP_002808 | 321-425 | in isoform GIRK2C | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_002805 | 328-425 | in isoform GIRK2B | |||
Sequence: Missing | ||||||
Sequence conflict | 381 | in Ref. 5; BAA88430 | ||||
Sequence: V → L | ||||||
Compositional bias | 394-425 | Basic and acidic residues | ||||
Sequence: HAELETEEEEKNPEELTERNGDVANLENESKV | ||||||
Alternative sequence | VSP_002803 | 415-425 | in isoform GIRK2-1 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U37253 EMBL· GenBank· DDBJ | AAA91457.1 EMBL· GenBank· DDBJ | mRNA | ||
U11859 EMBL· GenBank· DDBJ | AAA53245.1 EMBL· GenBank· DDBJ | mRNA | ||
U51122 EMBL· GenBank· DDBJ | AAC34141.1 EMBL· GenBank· DDBJ | mRNA | ||
U51123 EMBL· GenBank· DDBJ | AAC34142.1 EMBL· GenBank· DDBJ | mRNA | ||
U51124 EMBL· GenBank· DDBJ | AAC34143.1 EMBL· GenBank· DDBJ | mRNA | ||
U51125 EMBL· GenBank· DDBJ | AAC34144.1 EMBL· GenBank· DDBJ | mRNA | ||
U51126 EMBL· GenBank· DDBJ | AAC34145.1 EMBL· GenBank· DDBJ | mRNA | ||
AF040049 EMBL· GenBank· DDBJ | AAC34286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040047 EMBL· GenBank· DDBJ | AAC34286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040050 EMBL· GenBank· DDBJ | AAC34287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040049 EMBL· GenBank· DDBJ | AAC34287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040051 EMBL· GenBank· DDBJ | AAC34285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040047 EMBL· GenBank· DDBJ | AAC34285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040049 EMBL· GenBank· DDBJ | AAC34285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040052 EMBL· GenBank· DDBJ | AAC34284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040047 EMBL· GenBank· DDBJ | AAC34284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040049 EMBL· GenBank· DDBJ | AAC34284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF040051 EMBL· GenBank· DDBJ | AAC34284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
D86040 EMBL· GenBank· DDBJ | BAA12972.1 EMBL· GenBank· DDBJ | mRNA | ||
AB029502 EMBL· GenBank· DDBJ | BAA88430.1 EMBL· GenBank· DDBJ | mRNA |