P48451 · CANB1_DROME
- ProteinCalcineurin subunit B type 1
- GeneCanB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids170 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.
Miscellaneous
This protein has four functional calcium-binding sites.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 31 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 33 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 35 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 42 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 63 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 65 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 67 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 69 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 74 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 100 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 102 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 104 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 106 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 111 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 141 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 143 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 145 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 147 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 152 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | calcineurin complex | |
Cellular Component | synaptic vesicle | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent protein serine/threonine phosphatase regulator activity | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatase binding | |
Biological Process | calcineurin-mediated signaling | |
Biological Process | neurotransmitter secretion | |
Biological Process | sleep | |
Biological Process | vesicle-mediated transport |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcineurin subunit B type 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP48451
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000073488 | 1-170 | Calcineurin subunit B type 1 | |||
Sequence: MGNETSLPMDMCSNFDADEIRRLGKRFRKLDLDNSGALSIDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVRGDKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTICFADKDEDGKISFDEFCSVVGNTDIHKKMVVDV |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-46 | EF-hand 1 | ||||
Sequence: DEIRRLGKRFRKLDLDNSGALSIDEFMSL | ||||||
Domain | 50-85 | EF-hand 2 | ||||
Sequence: QQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVR | ||||||
Domain | 87-122 | EF-hand 3 | ||||
Sequence: DKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGN | ||||||
Domain | 128-163 | EF-hand 4 | ||||
Sequence: QLQQIVDKTICFADKDEDGKISFDEFCSVVGNTDIH |
Sequence similarities
Belongs to the calcineurin regulatory subunit family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length170
- Mass (Da)19,341
- Last updated1996-02-01 v1
- Checksum77D89BE9BD961900
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M9NFW6 | M9NFW6_DROME | CanB | 170 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M97215 EMBL· GenBank· DDBJ | AAA28411.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF46026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY070642 EMBL· GenBank· DDBJ | AAL48113.1 EMBL· GenBank· DDBJ | mRNA |