P48441 · IDUA_MOUSE

  • Protein
    Alpha-L-iduronidase
  • Gene
    Idua
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Catalytic activity

  • Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.
    EC:3.2.1.76 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

163450100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site44alpha-D-mannopyranose (UniProtKB | ChEBI)
Binding site46alpha-D-mannopyranose (UniProtKB | ChEBI)
Binding site48alpha-D-mannopyranose (UniProtKB | ChEBI)
Binding site81alpha-L-iduronate (UniProtKB | ChEBI)
Binding site171alpha-L-iduronate (UniProtKB | ChEBI)
Active site172Proton donor
Binding site172alpha-L-iduronate (UniProtKB | ChEBI)
Binding site254alpha-L-iduronate (UniProtKB | ChEBI)
Active site289Nucleophile
Binding site289alpha-L-iduronate (UniProtKB | ChEBI)
Binding site295alpha-L-iduronate (UniProtKB | ChEBI)
Binding site296alpha-D-mannopyranose (UniProtKB | ChEBI)
Binding site339alpha-L-iduronate (UniProtKB | ChEBI)
Binding site353alpha-L-iduronate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentlysosomal lumen
Cellular Componentlysosome
Molecular FunctionL-iduronidase activity
Molecular Functionsignaling receptor binding
Biological Processadult locomotory behavior
Biological Processadult walking behavior
Biological Processbone development
Biological Processcarbohydrate metabolic process
Biological Processcartilage homeostasis
Biological Processcell morphogenesis
Biological Processchemical homeostasis
Biological Processdermatan sulfate catabolic process
Biological Processextracellular matrix organization
Biological Processglycosaminoglycan catabolic process
Biological Processheparan sulfate proteoglycan catabolic process
Biological Processheparin catabolic process
Biological Processlimb morphogenesis
Biological Processlocomotory behavior
Biological Processlysosome organization
Biological Processmemory
Biological Processnegative regulation of cartilage development
Biological Processnegative regulation of secretion of lysosomal enzymes
Biological Processpositive regulation of bone resorption
Biological Processpositive regulation of collagen catabolic process
Biological Processskeletal system morphogenesis
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Idua

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6 X CBA
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P48441
  • Secondary accessions
    • E9QM17

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000001220117-634Alpha-L-iduronidase
Glycosylation100N-linked (GlcNAc...) asparagine
Glycosylation180N-linked (GlcNAc...) asparagine
Glycosylation233N-linked (GlcNAc...) asparagine
Glycosylation326N-linked (GlcNAc...) asparagine
Glycosylation362N-linked (GlcNAc...) asparagine
Glycosylation405N-linked (GlcNAc...) asparagine
Glycosylation441N-linked (GlcNAc...) asparagine
Disulfide bond531↔567

Post-translational modification

N-glycosylation contributes to substrate binding and is required for full enzymatic activity.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 39 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    634
  • Mass (Da)
    71,254
  • Last updated
    2011-07-27 v2
  • Checksum
    41A8F5B036B360DB
MLTFFAAFLAAPLALAESPYLVRVDAARPLRPLLPFWRSTGFCPPLPHDQADQYDLSWDQQLNLAYIGAVPHSGIEQVRIHWLLDLITARKSPGQGLMYNFTHLDAFLDLLMENQLLPGFELMGSPSGYFTDFDDKQQVFEWKDLVSLLARRYIGRYGLTHVSKWNFETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLKLGGPGDSFHPLPRSPMCWSLLGHCANGTNFFTGEVGVRLDYISLHKKGAGSSIAILEQEMAVVEQVQQLFPEFKDTPIYNDEADPLVGWSLPQPWRADVTYAALVVKVIAQHQNLLFANSSSSMRYVLLSNDNAFLSYHPYPFSQRTLTARFQVNNTHPPHVQLLRKPVLTVMGLMALLDGEQLWAEVSKAGAVLDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSDDTHAHPNHSIPVTLRLRGVPPGLDLVYIVLYLDNQLSSPYSAWQHMGQPVFPSAEQFRRMRMVEDPVAEAPRPFPARGRLTLHRKLPVPSLLLVHVCTRPLKPPGQVSRLRALPLTHGQLILVWSDERVGSKCLWTYEIQFSQKGEEYAPINRRPSTFNLFVFSPDTAVVSGSYRVRALDYWARPGPFSDPVTYLDVPAS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8BMG0Q8BMG0_MOUSEIdua643
Q8BLF6Q8BLF6_MOUSEIdua596
D6RIN7D6RIN7_MOUSEIdua151
D6REH5D6REH5_MOUSEIdua281

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict359in Ref. 1; AAC42044
Sequence conflict423in Ref. 1; AAC42044

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L34111
EMBL· GenBank· DDBJ
AAC42044.1
EMBL· GenBank· DDBJ
mRNA
AC161813
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

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