P48365 · GYP7_YEAST

Function

function

GTPase-activating protein (GAP) that most effectively accelerates the intrinsic GTPase activity of Ypt/Rab-type GTPase YPT7 involved in vacuole docking and fusion (PubMed:10091609, PubMed:11210571).
It is also active, but to a lesser extent, on YPT31, YPT32, YPT1, YPT6 and SEC4 (PubMed:10091609, PubMed:11210571).
Provides a catalytic arginine (arginine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable)

Miscellaneous

Present with 2460 molecules/cell in log phase SD medium.

Features

Showing features for site.

1746100200300400500600700
TypeIDPosition(s)Description
Site458Arginine finger

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentlate endosome
Molecular FunctionGTPase activator activity
Biological Processregulation of vacuole fusion, non-autophagic
Biological Processvesicle-mediated transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTPase-activating protein GYP7
  • Alternative names
    • GAP for YPT7

Gene names

    • Name
      GYP7
    • Ordered locus names
      YDL234C

Organism names

Accessions

  • Primary accession
    P48365
  • Secondary accessions
    • D6VRC2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis458Completely abolishes catalytic activity.

Variants

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The viewer provides 15 variants from UniProt as well as other sources including ClinVar and dbSNP.

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PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002080171-746GTPase-activating protein GYP7
Modified residue265Phosphoserine
Modified residue339Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P48365UBI4 P0CG632EBI-8018, EBI-7000452

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain385-633Rab-GAP TBC
Region470-505Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    746
  • Mass (Da)
    87,306
  • Last updated
    1996-02-01 v1
  • Checksum
    10F0F2B11A9993A6
MSKILFCKSKVFLHPTSDARDNIAGFLLLTLEANKLSHQAILQYIPESGLSTLEISKLLKHEAKVGTCPTSTPFVIENSINFSNLVNTSLGQAFEISLSQIYCIQFRPPSPNGWYVGSLVIYPLTEQFTGFQPPVLFFHDQLCPSTTDKLKRLRKSMNPFDDSDELYWGGVDLRNKINELMELKKSNLEPEFWLVNPSLNDLRNFVSKDLLESYNNSKKDTTELATAGVKLNEKFQEWKWNVMSKIADVTTKSTNFIDSWLTNNSPIQKSQIDNEYLQKLLNNEKVKQIEQDYDSARVYLANWSLGVKQEAERYQKQNKLFDSYRNNIFNDLNLTDELSDTEINNALQRQFPLTEAKWNSLWDENDGRLRVTVNEVKDFIFHGGLENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENNSTSPESANDESDDADDGVRNPHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFLRDQSGIHEQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVWFKREFEMEDIMHIWENFWTFYYSSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNELNGKLDWNDLMVRAELLFKKFEKMMHVMERDLQNVSSSSSSSSTGVLPCQSERLTLLLSKKPIIRHEGQRSKNSVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X79552
EMBL· GenBank· DDBJ
CAA56095.1
EMBL· GenBank· DDBJ
Genomic DNA
Z74281
EMBL· GenBank· DDBJ
CAA98813.1
EMBL· GenBank· DDBJ
Genomic DNA
Z74282
EMBL· GenBank· DDBJ
CAA98814.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006938
EMBL· GenBank· DDBJ
DAA11632.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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