P48365 · GYP7_YEAST
- ProteinGTPase-activating protein GYP7
- GeneGYP7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids746 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
GTPase-activating protein (GAP) that most effectively accelerates the intrinsic GTPase activity of Ypt/Rab-type GTPase YPT7 involved in vacuole docking and fusion (PubMed:10091609, PubMed:11210571).
It is also active, but to a lesser extent, on YPT31, YPT32, YPT1, YPT6 and SEC4 (PubMed:10091609, PubMed:11210571).
Provides a catalytic arginine (arginine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable)
It is also active, but to a lesser extent, on YPT31, YPT32, YPT1, YPT6 and SEC4 (PubMed:10091609, PubMed:11210571).
Provides a catalytic arginine (arginine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable)
Miscellaneous
Present with 2460 molecules/cell in log phase SD medium.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 458 | Arginine finger | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | late endosome | |
Molecular Function | GTPase activator activity | |
Biological Process | regulation of vacuole fusion, non-autophagic | |
Biological Process | vesicle-mediated transport |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTPase-activating protein GYP7
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP48365
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 458 | Completely abolishes catalytic activity. | ||||
Sequence: R → A or K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 15 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000208017 | 1-746 | GTPase-activating protein GYP7 | |||
Sequence: MSKILFCKSKVFLHPTSDARDNIAGFLLLTLEANKLSHQAILQYIPESGLSTLEISKLLKHEAKVGTCPTSTPFVIENSINFSNLVNTSLGQAFEISLSQIYCIQFRPPSPNGWYVGSLVIYPLTEQFTGFQPPVLFFHDQLCPSTTDKLKRLRKSMNPFDDSDELYWGGVDLRNKINELMELKKSNLEPEFWLVNPSLNDLRNFVSKDLLESYNNSKKDTTELATAGVKLNEKFQEWKWNVMSKIADVTTKSTNFIDSWLTNNSPIQKSQIDNEYLQKLLNNEKVKQIEQDYDSARVYLANWSLGVKQEAERYQKQNKLFDSYRNNIFNDLNLTDELSDTEINNALQRQFPLTEAKWNSLWDENDGRLRVTVNEVKDFIFHGGLENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENNSTSPESANDESDDADDGVRNPHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFLRDQSGIHEQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVWFKREFEMEDIMHIWENFWTFYYSSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNELNGKLDWNDLMVRAELLFKKFEKMMHVMERDLQNVSSSSSSSSTGVLPCQSERLTLLLSKKPIIRHEGQRSKNSVK | ||||||
Modified residue | 265 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 339 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P48365 | UBI4 P0CG63 | 2 | EBI-8018, EBI-7000452 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 385-633 | Rab-GAP TBC | ||||
Sequence: LENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENNSTSPESANDESDDADDGVRNPHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFLRDQSGIHEQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVWFKREFEMEDIMHIWENFWTFY | ||||||
Region | 470-505 | Disordered | ||||
Sequence: TIDGLPPPPQQLPANENNSTSPESANDESDDADDGV |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length746
- Mass (Da)87,306
- Last updated1996-02-01 v1
- Checksum10F0F2B11A9993A6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X79552 EMBL· GenBank· DDBJ | CAA56095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74281 EMBL· GenBank· DDBJ | CAA98813.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74282 EMBL· GenBank· DDBJ | CAA98814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA11632.1 EMBL· GenBank· DDBJ | Genomic DNA |