P48346 · IL15_MOUSE

  • Protein
    Interleukin-15
  • Gene
    Il15
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:11466332, PubMed:8757333).
Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8757333).
In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity).
Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed:10882748, PubMed:19632221).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentnuclear speck
Molecular Functioncytokine activity
Molecular Functioncytokine receptor binding
Biological Processcell maturation
Biological Processextrathymic T cell selection
Biological Processhyaluronan metabolic process
Biological Processimmune response
Biological Processinterleukin-15-mediated signaling pathway
Biological Processlymph node development
Biological Processmacrophage differentiation
Biological Processnatural killer cell differentiation
Biological Processnatural killer cell proliferation
Biological Processnegative regulation of cold-induced thermogenesis
Biological Processnegative regulation of smooth muscle cell proliferation
Biological Processneutrophil activation
Biological ProcessNK T cell proliferation
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of cytokine production
Biological Processpositive regulation of immune response
Biological Processpositive regulation of interleukin-17 production
Biological Processpositive regulation of natural killer cell differentiation
Biological Processpositive regulation of natural killer cell proliferation
Biological Processpositive regulation of peptidyl-tyrosine phosphorylation
Biological Processpositive regulation of phagocytosis
Biological Processpositive regulation of protein O-linked glycosylation
Biological Processpositive regulation of T cell proliferation
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processregulation of defense response to virus by host
Biological Processregulation of T cell differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-15
  • Short names
    IL-15

Gene names

    • Name
      Il15

Organism names

  • Taxonomic identifier
  • Strains
    • WC/REJ X C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P48346

Proteomes

Organism-specific databases

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-29
PropeptidePRO_000001539930-48
ChainPRO_000001540049-162Interleukin-15
Disulfide bond83↔133
Disulfide bond90↔136
Glycosylation104N-linked (GlcNAc...) asparagine
Glycosylation108N-linked (GlcNAc...) asparagine
Glycosylation119N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Induction

By type I interferons, double-stranded RNA, or lipopolysaccharides.

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the IL-15/IL-21 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    162
  • Mass (Da)
    18,593
  • Last updated
    1996-02-01 v1
  • Checksum
    68C971498CEBF296
MKILKPYMRNTSISCYLCFLLNSHFLTEAGIHVFILGCVSVGLPKTEANWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFINTS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1B0GQZ2A0A1B0GQZ2_MOUSEIl1548
A0A1B0GQZ8A0A1B0GQZ8_MOUSEIl1561

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U14332
EMBL· GenBank· DDBJ
AAA75377.1
EMBL· GenBank· DDBJ
mRNA
BC023698
EMBL· GenBank· DDBJ
AAH23698.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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