P48307 · TFPI2_HUMAN
- ProteinTissue factor pathway inhibitor 2
- GeneTFPI2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids235 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 46-47 | Reactive bond | ||||
Sequence: RA | ||||||
Site | 107-108 | Reactive bond | ||||
Sequence: EG | ||||||
Site | 168-169 | Reactive bond | ||||
Sequence: SA |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | extracellular matrix structural constituent | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Biological Process | blood coagulation | |
Biological Process | cellular response to fluid shear stress |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameTissue factor pathway inhibitor 2
- Short namesTFPI-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP48307
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_012005 | 102 | in dbSNP:rs1804202 | |||
Sequence: V → A | ||||||
Natural variant | VAR_050064 | 231 | in dbSNP:rs12669450 | |||
Sequence: R → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 293 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-22 | UniProt | |||||
Sequence: MDPARPLGLSILLLFLTEAALG | |||||||
Chain | PRO_0000016876 | 23-235 | UniProt | Tissue factor pathway inhibitor 2 | |||
Sequence: DAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF | |||||||
Disulfide bond | 36↔86 | UniProt | |||||
Sequence: CLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDAC | |||||||
Disulfide bond | 45↔69 | UniProt | |||||
Sequence: CRALLLRYYYDRYTQSCRQFLYGGC | |||||||
Disulfide bond | 61↔82 | UniProt | |||||
Sequence: CRQFLYGGCEGNANNFYTWEAC | |||||||
Disulfide bond | 96↔149 | UniProt | |||||
Sequence: CRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFC | |||||||
Disulfide bond | 106↔130 | UniProt | |||||
Sequence: CEGSTEKYFFNLSSMTCEKFFSGGC | |||||||
Glycosylation | 116 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 122↔145 | UniProt | |||||
Sequence: CEKFFSGGCHRNRIENRFPDEATC | |||||||
Disulfide bond | 158↔208 | UniProt | |||||
Sequence: CYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRAC | |||||||
Disulfide bond | 167↔191 | UniProt | |||||
Sequence: CSANVTRYYFNPRYRTCDAFTYTGC | |||||||
Modified residue (large scale data) | 168 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 170 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 183↔204 | UniProt | |||||
Sequence: CDAFTYTGCGGNDNNFVSREDC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-86 | BPTI/Kunitz inhibitor 1 | ||||
Sequence: CLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDAC | ||||||
Domain | 96-149 | BPTI/Kunitz inhibitor 2 | ||||
Sequence: CRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFC | ||||||
Domain | 158-208 | BPTI/Kunitz inhibitor 3 | ||||
Sequence: CYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRAC |
Domain
This inhibitor contains three inhibitory domains.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P48307-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length235
- Mass (Da)26,934
- Last updated1996-02-01 v1
- Checksum975ABA5C53F7C65F
P48307-2
- Name2
- Differences from canonical
- 30-40: Missing
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H7C4A3 | H7C4A3_HUMAN | TFPI2 | 107 | ||
A0A3B3IS67 | A0A3B3IS67_HUMAN | TFPI2 | 241 | ||
A0A3B3IRW1 | A0A3B3IRW1_HUMAN | TFPI2 | 169 | ||
A0A3B3ISY1 | A0A3B3ISY1_HUMAN | TFPI2 | 161 |
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 23 | in Ref. 11; AA sequence | ||||
Sequence: D → A | ||||||
Sequence conflict | 23 | in Ref. 10; AA sequence | ||||
Sequence: D → G | ||||||
Alternative sequence | VSP_056031 | 30-40 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 36 | in Ref. 10; AA sequence | ||||
Sequence: C → I | ||||||
Sequence conflict | 42 | in Ref. 10; AA sequence | ||||
Sequence: Y → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D29992 EMBL· GenBank· DDBJ | BAA06272.1 EMBL· GenBank· DDBJ | mRNA | ||
L27624 EMBL· GenBank· DDBJ | AAA20094.1 EMBL· GenBank· DDBJ | mRNA | ||
AF217542 EMBL· GenBank· DDBJ | AAK13254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY691946 EMBL· GenBank· DDBJ | AAU04568.1 EMBL· GenBank· DDBJ | mRNA | ||
AK092499 EMBL· GenBank· DDBJ | BAC03906.1 EMBL· GenBank· DDBJ | mRNA | ||
AK313260 EMBL· GenBank· DDBJ | BAG36070.1 EMBL· GenBank· DDBJ | mRNA | ||
AC002076 EMBL· GenBank· DDBJ | AAS02022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH236949 EMBL· GenBank· DDBJ | EAL24140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471091 EMBL· GenBank· DDBJ | EAW76809.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471091 EMBL· GenBank· DDBJ | EAW76811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC005330 EMBL· GenBank· DDBJ | AAH05330.1 EMBL· GenBank· DDBJ | mRNA |