P48307 · TFPI2_HUMAN

  • Protein
    Tissue factor pathway inhibitor 2
  • Gene
    TFPI2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Features

Showing features for site.

123520406080100120140160180200220
TypeIDPosition(s)Description
Site46-47Reactive bond
Site107-108Reactive bond
Site168-169Reactive bond

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Molecular Functionextracellular matrix structural constituent
Molecular Functionserine-type endopeptidase inhibitor activity
Biological Processblood coagulation
Biological Processcellular response to fluid shear stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Tissue factor pathway inhibitor 2
  • Short names
    TFPI-2
  • Alternative names
    • Placental protein 5 (PP5)

Gene names

    • Name
      TFPI2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P48307
  • Secondary accessions
    • Q66ME8
    • Q8NAK6
    • Q9UC86

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_012005102in dbSNP:rs1804202
Natural variantVAR_050064231in dbSNP:rs12669450

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 293 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Signal1-22UniProt
ChainPRO_000001687623-235UniProtTissue factor pathway inhibitor 2
Disulfide bond36↔86UniProt
Disulfide bond45↔69UniProt
Disulfide bond61↔82UniProt
Disulfide bond96↔149UniProt
Disulfide bond106↔130UniProt
Glycosylation116UniProtN-linked (GlcNAc...) asparagine
Disulfide bond122↔145UniProt
Disulfide bond158↔208UniProt
Disulfide bond167↔191UniProt
Modified residue (large scale data)168PRIDEPhosphoserine
Glycosylation170UniProtN-linked (GlcNAc...) asparagine
Disulfide bond183↔204UniProt

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-86BPTI/Kunitz inhibitor 1
Domain96-149BPTI/Kunitz inhibitor 2
Domain158-208BPTI/Kunitz inhibitor 3

Domain

This inhibitor contains three inhibitory domains.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P48307-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    235
  • Mass (Da)
    26,934
  • Last updated
    1996-02-01 v1
  • Checksum
    975ABA5C53F7C65F
MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF

P48307-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H7C4A3H7C4A3_HUMANTFPI2107
A0A3B3IS67A0A3B3IS67_HUMANTFPI2241
A0A3B3IRW1A0A3B3IRW1_HUMANTFPI2169
A0A3B3ISY1A0A3B3ISY1_HUMANTFPI2161

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict23in Ref. 11; AA sequence
Sequence conflict23in Ref. 10; AA sequence
Alternative sequenceVSP_05603130-40in isoform 2
Sequence conflict36in Ref. 10; AA sequence
Sequence conflict42in Ref. 10; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D29992
EMBL· GenBank· DDBJ
BAA06272.1
EMBL· GenBank· DDBJ
mRNA
L27624
EMBL· GenBank· DDBJ
AAA20094.1
EMBL· GenBank· DDBJ
mRNA
AF217542
EMBL· GenBank· DDBJ
AAK13254.1
EMBL· GenBank· DDBJ
Genomic DNA
AY691946
EMBL· GenBank· DDBJ
AAU04568.1
EMBL· GenBank· DDBJ
mRNA
AK092499
EMBL· GenBank· DDBJ
BAC03906.1
EMBL· GenBank· DDBJ
mRNA
AK313260
EMBL· GenBank· DDBJ
BAG36070.1
EMBL· GenBank· DDBJ
mRNA
AC002076
EMBL· GenBank· DDBJ
AAS02022.1
EMBL· GenBank· DDBJ
Genomic DNA
CH236949
EMBL· GenBank· DDBJ
EAL24140.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471091
EMBL· GenBank· DDBJ
EAW76809.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471091
EMBL· GenBank· DDBJ
EAW76811.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005330
EMBL· GenBank· DDBJ
AAH05330.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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