P48182 · ACR2_CAEEL

  • Protein
    Acetylcholine receptor subunit beta-type acr-2
  • Gene
    acr-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Non-alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:20027209, PubMed:8581398).
Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209, PubMed:23658528, PubMed:27782882).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacetylcholine-gated channel complex
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Molecular Functionacetylcholine-gated monoatomic cation-selective channel activity
Molecular Functionexcitatory extracellular ligand-gated monoatomic ion channel activity
Molecular Functiontransmembrane signaling receptor activity
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Processcalcium ion import across plasma membrane
Biological Processinorganic cation transmembrane transport
Biological Processneuromuscular synaptic transmission
Biological Processpositive regulation of translation
Biological Processregulation of gene expression
Biological Processregulation of locomotion
Biological Processregulation of muscle contraction

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 1.A.9.1.13the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
    • 1.A.9.1.2the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomy

Protein names

  • Recommended name
    Acetylcholine receptor subunit beta-type acr-2

Gene names

    • Name
      acr-2
    • ORF names
      K11G12.2

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P48182

Proteomes

Organism-specific databases

Subcellular Location

Postsynaptic cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain21-270Extracellular
Transmembrane271-291Helical
Transmembrane299-319Helical
Transmembrane331-351Helical
Topological domain352-527Cytoplasmic
Transmembrane528-548Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Locomotion is slower. Moderately resistant to paralysis induced by acetylcholine esterase inhibitor aldicarb but sensitivity to acetylcholine agonist levamisole is normal. Reduced both cholinergic and GABAergic motoneuron activities characterized by a reduction in miniature postsynaptic currents in muscles.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis309In n2420; constitutively active. Spontaneous convulsions and shrinking behavior in response to touch. Convulsions are suppressed in an unc-74, unc-50, unc-38 or unc-63 mutant background. Enhanced neurotransmitter release by cholinergic motoneurons and reduced neurotransmitter release by GABAergic motoneurons. Increases neuropeptide flp-18 expression in cholinergic B-type motor neurons. Increases sensitivity to paralysis induced by acetylcholine esterase inhibitor aldicarb or acetylcholine agonist levamisole in L3-L4 larvae and adults.

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000000039821-575Acetylcholine receptor subunit beta-type acr-2
Glycosylation41N-linked (GlcNAc...) asparagine
Glycosylation42N-linked (GlcNAc...) asparagine
Glycosylation80N-linked (GlcNAc...) asparagine
Glycosylation131N-linked (GlcNAc...) asparagine
Disulfide bond185↔199

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Specifically expressed in cholinergic ventral cord motoneurons of the VA, VB, DA and DB classes but not AS and VC classes. Expressed in PVQ and DVC neurons in the tail.

Developmental stage

Expressed from L1 larval stage through adults.

Gene expression databases

Interaction

Subunit

Component of nicotinic acetylcholine receptor. In cholinergic motoneurons, composed of 2 non-alpha subunits acr-2 and acr-3, and 3 alpha subunits unc-38, unc-63 and acr-12.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region31-57Disordered
Compositional bias35-51Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    575
  • Mass (Da)
    65,595
  • Last updated
    1996-02-01 v1
  • Checksum
    7EB24296100EEB05
MKKTVKILLILITVFLKVHCNGGHDDEAADFLSHTNIDDPNNSSDPNKNSDQGDTMGEDEDRLVIDLFREYNFLIRPVKNVSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLAWNPAEYGNISNLHVPSDRVWLPDIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRIDVEWFPFDEQCCTLVFGSWTYNSEEVRLHWYNNIQAVQLHDYSYSGIWDVIDVPGQLVHKPDLKENKMVFNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTISLLLALVVFLLLVSKILPPTSNIPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALSHKMPTWVRKVFLEFLPHLLVMKRPERIPIFNGYFVEEYCASEIFDASLVMPSMTATMLPFLQVTTNLKAASSTSSGQSSEHHENCSKWKKRLSIRMSKRRAPRARLDDDSEDIIDDTNGNHVDSLQEKISKEMKTTVEAIAYIAEHMKREMSLKKMRDDWKYVAMVLDRLILLIFFGVTLGGTLGIICSAPHVFDFVDQEAIISKLNAKYLPSDMYS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias35-51Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X86403
EMBL· GenBank· DDBJ
CAA60157.1
EMBL· GenBank· DDBJ
mRNA
FO081325
EMBL· GenBank· DDBJ
CCD70794.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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