P47977 · CTH2_YEAST

Function

function

Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3'-end processing, creating extended transcripts that are prone for degradation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular ComponentP-body
Molecular Functionmetal ion binding
Molecular FunctionmRNA binding
Molecular Functiontranslation repressor activity
Biological Processelectron transport coupled proton transport
Biological Processintracellular iron ion homeostasis
Biological Processnegative regulation of cytoplasmic translation
Biological Processnuclear-transcribed mRNA catabolic process
Biological Processresponse to iron ion starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mRNA decay factor CTH2
  • Alternative names
    • Cysteine-three-histidine protein 2
    • Protein TIS11 homolog
    • Protein YTIS11
    • TPA-induced sequence protein 11

Gene names

    • Name
      TIS11
    • Synonyms
      CTH2
    • ORF names
      L3143, L9606.12
    • Ordered locus names
      YLR136C

Organism names

Accessions

  • Primary accession
    P47977
  • Secondary accessions
    • D6VYD1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis190Abolishes mRNA binding.
Mutagenesis213Abolishes mRNA binding.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000891741-285mRNA decay factor CTH2

Proteomic databases

PTM databases

Expression

Induction

By transcription factors AFT1 and AFT2 in response to iron deficiency.

Interaction

Subunit

Interacts with DHH1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, zinc finger.

TypeIDPosition(s)Description
Region37-55Required for mRNA decay activity
Region132-164Disordered
Zinc finger169-197C3H1-type 1
Zinc finger207-235C3H1-type 2
Region252-271Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    32,314
  • Last updated
    1996-10-01 v1
  • Checksum
    72E041AE31EC4099
MWAQLSYTRPESQKTDLTSLFSTDQEQNPLNDYQYQINIRELEEYYNKTILNEDNIQETSSEISSAVSFSPPKNTNAIQPGLLYDPQLMNPFLPSAHLNSTAPTTFKKKLEVQINPDYVPKSSQLPLTSQNLQQLSQQKPKNDASFSSEKESSAQPKVKSQVQETPKQLYKTELCESFTLKGSCPYGSKCQFAHGLGELKVKKSCKNFRTKPCVNWEKLGYCPYGRRCCFKHGDDNDIAVYVKAGTYCNVSSTSKQSDEKRSNGRGSAKKKNLNVKVKALQRMTW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S76619
EMBL· GenBank· DDBJ
AAB33266.1
EMBL· GenBank· DDBJ
Genomic DNA
L42134
EMBL· GenBank· DDBJ
AAB39898.1
EMBL· GenBank· DDBJ
Genomic DNA
X91258
EMBL· GenBank· DDBJ
CAA62651.1
EMBL· GenBank· DDBJ
Genomic DNA
Z73308
EMBL· GenBank· DDBJ
CAA97707.1
EMBL· GenBank· DDBJ
Genomic DNA
U53881
EMBL· GenBank· DDBJ
AAB82400.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558210
EMBL· GenBank· DDBJ
AAS56536.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006945
EMBL· GenBank· DDBJ
DAA09447.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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