P47944 · MT4_HUMAN

  • Protein
    Metallothionein-4
  • Gene
    MT4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Features

Showing features for binding site.

16251015202530354045505560
MDPRECVCMSGGICMCGDNCKCTTCNCKTYWKSCCPCCPPGCAKCARGCICKGGSDKCSCCP
TypeIDPosition(s)Description
Binding site6a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site8a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site8a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site14a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site16a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site16a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site20a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site22a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site25a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site25a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site27a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site34a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site35a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site35a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site37a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site38a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site38a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site42a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site45a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site45a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site49a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site51a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site51a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site58a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site60a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site61a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site61a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Biological Processcellular response to cadmium ion
Biological Processcellular response to copper ion
Biological Processcellular response to zinc ion
Biological Processdetoxification of copper ion
Biological Processintracellular zinc ion homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metallothionein-4
  • Short names
    MT-4
  • Alternative names
    • Metallothionein-IV (MT-IV)

Gene names

    • Name
      MT4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P47944
  • Secondary accessions
    • Q14DA1

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03411030in dbSNP:rs666636
Natural variantVAR_03411131in dbSNP:rs666647
Natural variantVAR_03411248in dbSNP:rs11643815

Variants

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The viewer provides 90 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001972551-62Metallothionein-4

Proteomic databases

Expression

Gene expression databases

    • ENSG00000102891Expressed in primordial germ cell in gonad and 76 other cell types or tissues

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    62
  • Mass (Da)
    6,509
  • Last updated
    2010-02-09 v2
  • Checksum
    55DA475A17BF28C9
MDPRECVCMSGGICMCGDNCKCTTCNCKTYWKSCCPCCPPGCAKCARGCICKGGSDKCSCCP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U07807
EMBL· GenBank· DDBJ
AAA20232.1
EMBL· GenBank· DDBJ
Genomic DNA
AC026461
EMBL· GenBank· DDBJ
-mRNA No translation available.
BC113442
EMBL· GenBank· DDBJ
AAI13443.1
EMBL· GenBank· DDBJ
mRNA
BC113444
EMBL· GenBank· DDBJ
AAI13445.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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