P47937 · NK3R_MOUSE
- ProteinNeuromedin-K receptor
- GeneTacr3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids452 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite membrane | |
Cellular Component | neuronal cell body membrane | |
Cellular Component | plasma membrane | |
Cellular Component | sperm midpiece | |
Molecular Function | tachykinin receptor activity | |
Biological Process | positive regulation of blood pressure | |
Biological Process | positive regulation of flagellated sperm motility | |
Biological Process | positive regulation of heart rate | |
Biological Process | positive regulation of uterine smooth muscle contraction | |
Biological Process | regulation of dopamine metabolic process | |
Biological Process | regulation of feeding behavior | |
Biological Process | response to cocaine | |
Biological Process | response to estradiol |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeuromedin-K receptor
- Short namesNKR
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP47937
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-71 | Extracellular | ||||
Sequence: MASVPTGENWTDGTAGVGSHTGNLSAALGITEWLALQAGNFSSALGLPVTSQAPSQVRANLTNQFVQPSWR | ||||||
Transmembrane | 72-94 | Helical; Name=1 | ||||
Sequence: IALWSLAYGLVVAVAVFGNLIVI | ||||||
Topological domain | 95-104 | Cytoplasmic | ||||
Sequence: WIILAHKRMR | ||||||
Transmembrane | 105-126 | Helical; Name=2 | ||||
Sequence: TVTNYFLVNLAFSDASVAAFNT | ||||||
Topological domain | 127-146 | Extracellular | ||||
Sequence: LVNFIYGVHSEWYFGANYCR | ||||||
Transmembrane | 147-168 | Helical; Name=3 | ||||
Sequence: FQNFFPITAVFASIYSMTAIAV | ||||||
Topological domain | 169-188 | Cytoplasmic | ||||
Sequence: DRYMAIIDPLKPRLSATATK | ||||||
Transmembrane | 189-209 | Helical; Name=4 | ||||
Sequence: IVIGSIWILAFLLAFPQCLYS | ||||||
Topological domain | 210-232 | Extracellular | ||||
Sequence: KIKVMPGRTLCYVQWPEGPKQHF | ||||||
Transmembrane | 233-257 | Helical; Name=5 | ||||
Sequence: TYHIIVIILVYCFPLLIMGVTYTIV | ||||||
Topological domain | 258-286 | Cytoplasmic | ||||
Sequence: GITLWGGEIPGDTCDKYHEQLKAKRKVVK | ||||||
Transmembrane | 287-308 | Helical; Name=6 | ||||
Sequence: MMIIVVVTFAICWLPYHVYFIL | ||||||
Topological domain | 309-321 | Extracellular | ||||
Sequence: TAIYQQLNRWKYI | ||||||
Transmembrane | 322-346 | Helical; Name=7 | ||||
Sequence: QQVYLASFWLAMSSTMYNPIIYCCL | ||||||
Topological domain | 347-452 | Cytoplasmic | ||||
Sequence: NKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLYDPSEGDPAKSSRKKRAVPRDPSANGCSHREFKSASTTSSFISSPYTSVDEYS |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069900 | 1-452 | Neuromedin-K receptor | |||
Sequence: MASVPTGENWTDGTAGVGSHTGNLSAALGITEWLALQAGNFSSALGLPVTSQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLVNFIYGVHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLYDPSEGDPAKSSRKKRAVPRDPSANGCSHREFKSASTTSSFISSPYTSVDEYS | ||||||
Glycosylation | 9 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 23 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 40 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 60 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 145↔220 | |||||
Sequence: CRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLC | ||||||
Lipidation | 361 | S-palmitoyl cysteine | ||||
Sequence: C |
Post-translational modification
The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 401-452 | Disordered | ||||
Sequence: DPSEGDPAKSSRKKRAVPRDPSANGCSHREFKSASTTSSFISSPYTSVDEYS | ||||||
Compositional bias | 428-452 | Polar residues | ||||
Sequence: HREFKSASTTSSFISSPYTSVDEYS |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length452
- Mass (Da)51,026
- Last updated2003-05-30 v2
- Checksum7A46D400AD7FC444
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 59 | in Ref. 3; CAA61088 | ||||
Sequence: A → D | ||||||
Sequence conflict | 198 | in Ref. 4; AAA17893 | ||||
Sequence: A → S | ||||||
Sequence conflict | 267 | in Ref. 3; CAA61088 | ||||
Sequence: P → L | ||||||
Sequence conflict | 385 | in Ref. 3; CAA61088 | ||||
Sequence: S → P | ||||||
Compositional bias | 428-452 | Polar residues | ||||
Sequence: HREFKSASTTSSFISSPYTSVDEYS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF233341 EMBL· GenBank· DDBJ | AAF62517.1 EMBL· GenBank· DDBJ | mRNA | ||
AK031898 EMBL· GenBank· DDBJ | BAC27596.1 EMBL· GenBank· DDBJ | mRNA | ||
AK046424 EMBL· GenBank· DDBJ | BAC32723.1 EMBL· GenBank· DDBJ | mRNA | ||
X87823 EMBL· GenBank· DDBJ | CAA61088.1 EMBL· GenBank· DDBJ | mRNA | ||
L27827 EMBL· GenBank· DDBJ | AAA17893.1 EMBL· GenBank· DDBJ | mRNA |