P47927 · AP2_ARATH
- ProteinFloral homeotic protein APETALA 2
- GeneAP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids432 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Probable transcriptional activator that promotes early floral meristem identity (PubMed:7919989).
Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:1675158).
Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes (PubMed:1675158, PubMed:23034631).
Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and SEUSS (PubMed:1675158).
Directly represses AGAMOUS by recruiting the transcriptional corepressor TOPLESS and the histone deacetylase HDA19 (PubMed:23034631).
It is also required during seed development (PubMed:1675158).
Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:1675158).
Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes (PubMed:1675158, PubMed:23034631).
Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and SEUSS (PubMed:1675158).
Directly represses AGAMOUS by recruiting the transcriptional corepressor TOPLESS and the histone deacetylase HDA19 (PubMed:23034631).
It is also required during seed development (PubMed:1675158).
Miscellaneous
Mutations in the APETALA2 gene result in the ectopic expression of AGAMOUS, leading to the replacement of sepals by carpels and stamens and of petals by stamens.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 131-187 | AP2/ERF 1 | ||||
Sequence: QYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVEADINFN | ||||||
DNA binding | 223-280 | AP2/ERF 2 | ||||
Sequence: KYRGVTLHKCGRWEARMGQFLGKKYVYLGLFDTEVEAARAYDKAAIKCNGKDAVTNFD |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | cell differentiation | |
Biological Process | flower development | |
Biological Process | meristem maintenance | |
Biological Process | plant ovule development | |
Biological Process | seed development | |
Biological Process | specification of floral organ identity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameFloral homeotic protein APETALA 2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP47927
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 159 | In AP2-5; temperature-sensitive. | ||||
Sequence: G → E | ||||||
Mutagenesis | 251 | In AP2-1; temperature-sensitive. | ||||
Sequence: G → S | ||||||
Mutagenesis | 304-308 | Loss of interaction with TPL. | ||||
Sequence: LDLSL → ADASA | ||||||
Mutagenesis | 420 | In AP2-5; temperature-sensitive. | ||||
Sequence: Q → E |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000112522 | 1-432 | Floral homeotic protein APETALA 2 | |||
Sequence: MWDLNDAPHQTQREEESEEFCYSSPSKRVGSFSNSSSSAVVIEDGSDDDELNRVRPNNPLVTHQFFPEMDSNGGGVASGFPRAHWFGVKFCQSDLATGSSAGKATNVAAAVVEPAQPLKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVEADINFNIDDYDDDLKQMTNLTKEEFVHVLRRQSTGFPRGSSKYRGVTLHKCGRWEARMGQFLGKKYVYLGLFDTEVEAARAYDKAAIKCNGKDAVTNFDPSIYDEELNAESSGNPTTPQDHNLDLSLGNSANSKHKSQDMRLRMNQQQQDSLHSNEVLGLGQTGMLNHTPNSNHQFPGSSNIGSGGGFSLFPAAENHRFDGRASTNQVLTNAAASSGFSPHHHNQIFNSTSTPHQNWLQTNGFQPPLMRPS |
Proteomic databases
Expression
Tissue specificity
Sepals, petals, stamens, carpels, developing ovules, inflorescence stem, leaf and stem.
Induction
Negatively regulated by the C class floral homeotic protein AGAMOUS in stamens and carpels. MicroRNA 172 (miRNA172) negatively regulates APETALA2 at the translational level and may modulate its expression pattern. Seems not to be influenced by jasmonate and Alternaria brassicicola.
Developmental stage
It is detectable at low levels throughout the shoot apex and at enhanced levels in the inflorescence meristem, young floral buds and throughout the early stages of flower development and organogenesis. During floral organ differentiation it becomes spatially restricted to specific organ, tissue and cell types within the flower.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-56 | Disordered | ||||
Sequence: MWDLNDAPHQTQREEESEEFCYSSPSKRVGSFSNSSSSAVVIEDGSDDDELNRVRP | ||||||
Compositional bias | 8-22 | Basic and acidic residues | ||||
Sequence: PHQTQREEESEEFCY | ||||||
Compositional bias | 24-42 | Polar residues | ||||
Sequence: SPSKRVGSFSNSSSSAVVI | ||||||
Motif | 119-128 | Nuclear localization signal | ||||
Sequence: KKSRRGPRSR | ||||||
Region | 287-362 | Disordered | ||||
Sequence: ELNAESSGNPTTPQDHNLDLSLGNSANSKHKSQDMRLRMNQQQQDSLHSNEVLGLGQTGMLNHTPNSNHQFPGSSN | ||||||
Compositional bias | 288-316 | Polar residues | ||||
Sequence: LNAESSGNPTTPQDHNLDLSLGNSANSKH | ||||||
Motif | 304-308 | EAR | ||||
Sequence: LDLSL | ||||||
Compositional bias | 323-362 | Polar residues | ||||
Sequence: LRMNQQQQDSLHSNEVLGLGQTGMLNHTPNSNHQFPGSSN | ||||||
Region | 395-432 | Disordered | ||||
Sequence: ASSGFSPHHHNQIFNSTSTPHQNWLQTNGFQPPLMRPS |
Sequence similarities
Belongs to the AP2/ERF transcription factor family. AP2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length432
- Mass (Da)47,833
- Last updated1996-02-01 v1
- Checksum376A355291EFFB42
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 8-22 | Basic and acidic residues | ||||
Sequence: PHQTQREEESEEFCY | ||||||
Compositional bias | 24-42 | Polar residues | ||||
Sequence: SPSKRVGSFSNSSSSAVVI | ||||||
Compositional bias | 288-316 | Polar residues | ||||
Sequence: LNAESSGNPTTPQDHNLDLSLGNSANSKH | ||||||
Compositional bias | 323-362 | Polar residues | ||||
Sequence: LRMNQQQQDSLHSNEVLGLGQTGMLNHTPNSNHQFPGSSN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U12546 EMBL· GenBank· DDBJ | AAC13770.1 EMBL· GenBank· DDBJ | mRNA | ||
Z99707 EMBL· GenBank· DDBJ | CAB16765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161590 EMBL· GenBank· DDBJ | CAB80358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE86717.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE86718.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY128328 EMBL· GenBank· DDBJ | AAM91531.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |