P47927 · AP2_ARATH

Function

function

Probable transcriptional activator that promotes early floral meristem identity (PubMed:7919989).
Is required subsequently for the transition of an inflorescence meristem into a floral meristem (PubMed:1675158).
Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes (PubMed:1675158, PubMed:23034631).
Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and SEUSS (PubMed:1675158).
Directly represses AGAMOUS by recruiting the transcriptional corepressor TOPLESS and the histone deacetylase HDA19 (PubMed:23034631).
It is also required during seed development (PubMed:1675158).

Miscellaneous

Mutations in the APETALA2 gene result in the ectopic expression of AGAMOUS, leading to the replacement of sepals by carpels and stamens and of petals by stamens.

Features

Showing features for dna binding.

143250100150200250300350400
TypeIDPosition(s)Description
DNA binding131-187AP2/ERF 1
DNA binding223-280AP2/ERF 2

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processcell differentiation
Biological Processflower development
Biological Processmeristem maintenance
Biological Processplant ovule development
Biological Processseed development
Biological Processspecification of floral organ identity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Floral homeotic protein APETALA 2

Gene names

    • Name
      AP2
    • ORF names
      AP22.49, C7A10.440
    • Ordered locus names
      At4g36920

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P47927
  • Secondary accessions
    • Q8L7P9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis159In AP2-5; temperature-sensitive.
Mutagenesis251In AP2-1; temperature-sensitive.
Mutagenesis304-308Loss of interaction with TPL.
Mutagenesis420In AP2-5; temperature-sensitive.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001125221-432Floral homeotic protein APETALA 2

Proteomic databases

Expression

Tissue specificity

Sepals, petals, stamens, carpels, developing ovules, inflorescence stem, leaf and stem.

Induction

Negatively regulated by the C class floral homeotic protein AGAMOUS in stamens and carpels. MicroRNA 172 (miRNA172) negatively regulates APETALA2 at the translational level and may modulate its expression pattern. Seems not to be influenced by jasmonate and Alternaria brassicicola.

Developmental stage

It is detectable at low levels throughout the shoot apex and at enhanced levels in the inflorescence meristem, young floral buds and throughout the early stages of flower development and organogenesis. During floral organ differentiation it becomes spatially restricted to specific organ, tissue and cell types within the flower.

Gene expression databases

Interaction

Subunit

May form homodimer. Interacts with HDA19 and with TPL in an EAR-motif dependent manner (PubMed:23034631).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region1-56Disordered
Compositional bias8-22Basic and acidic residues
Compositional bias24-42Polar residues
Motif119-128Nuclear localization signal
Region287-362Disordered
Compositional bias288-316Polar residues
Motif304-308EAR
Compositional bias323-362Polar residues
Region395-432Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    47,833
  • Last updated
    1996-02-01 v1
  • Checksum
    376A355291EFFB42
MWDLNDAPHQTQREEESEEFCYSSPSKRVGSFSNSSSSAVVIEDGSDDDELNRVRPNNPLVTHQFFPEMDSNGGGVASGFPRAHWFGVKFCQSDLATGSSAGKATNVAAAVVEPAQPLKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVEADINFNIDDYDDDLKQMTNLTKEEFVHVLRRQSTGFPRGSSKYRGVTLHKCGRWEARMGQFLGKKYVYLGLFDTEVEAARAYDKAAIKCNGKDAVTNFDPSIYDEELNAESSGNPTTPQDHNLDLSLGNSANSKHKSQDMRLRMNQQQQDSLHSNEVLGLGQTGMLNHTPNSNHQFPGSSNIGSGGGFSLFPAAENHRFDGRASTNQVLTNAAASSGFSPHHHNQIFNSTSTPHQNWLQTNGFQPPLMRPS

Sequence caution

The sequence AAM91531.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias8-22Basic and acidic residues
Compositional bias24-42Polar residues
Compositional bias288-316Polar residues
Compositional bias323-362Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U12546
EMBL· GenBank· DDBJ
AAC13770.1
EMBL· GenBank· DDBJ
mRNA
Z99707
EMBL· GenBank· DDBJ
CAB16765.1
EMBL· GenBank· DDBJ
Genomic DNA
AL161590
EMBL· GenBank· DDBJ
CAB80358.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE86717.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE86718.1
EMBL· GenBank· DDBJ
Genomic DNA
AY128328
EMBL· GenBank· DDBJ
AAM91531.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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