P47792 · SX19A_DANRE

Function

function

Transcriptional activator.

Features

Showing features for dna binding.

129720406080100120140160180200220240260280
TypeIDPosition(s)Description
DNA binding53-121HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processbrain development
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuron differentiation
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor Sox-19a

Gene names

    • Name
      sox19a
    • Synonyms
      sox19
    • ORF names
      si:ch211-137i24.8

Organism names

  • Taxonomic identifier
  • Strains
    • WT
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    P47792
  • Secondary accessions
    • A2BEN6
    • Q6DC63

Proteomes

    • Identifier
    • Component
      Alternate scaffold 5, Chromosome 5

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000487761-297Transcription factor Sox-19a
Modified residue160Phosphoserine

Keywords

PTM databases

Expression

Developmental stage

Expressed zygotically. First detected at the mid-blastula transition. Confined to the future ectoderm by the shield stage, and to the presumptive neuroectoderm by the 75-80% epiboly stage. From the tail bud to the 3-somite stage, expressed throughout the neural plate, except in the anterior margin; strongest expression in the presumptive ventral diencephalon. At the 12- to 25-somite stage, expressed broadly in the central nervous system. From 24-30 hours post-fertilization, restricted to the ventral diencephalon, midbrain and hindbrain/anterior spinal cord region, and to the retina and lens.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-52Disordered
Compositional bias14-51Polar residues
Compositional bias219-249Polar residues
Region219-255Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    32,785
  • Last updated
    2006-05-30 v2
  • Checksum
    5990122DC7A953EA
MYSMLEHDMKSAVPPTHQSAQGMTQLNGGVTHGSAKPAVNSQQQQSSDPMDKVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTDAEKRPFIDEAKRLRALHMKEYPDYKYKPRRKTKPVLKKDNPAAKYPLSAGNLLAAAAAQGSGGSPRMDSYGWGHTGGYPGMQTDALGYSQQLHRYDLSALQYPSAMATAQTYMNGANSYNPMSYSSTPQQPSPVMSMVKPEQVSHSPTGAHSHQRGPLQGDLRDMISMYIPGGDTTDSGAQRGYSNIQQHYLTGTAPLTHI

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias14-51Polar residues
Sequence conflict27-33in Ref. 1; CAA56221
Sequence conflict39-41in Ref. 1; CAA56221
Sequence conflict47in Ref. 1; CAA56221
Sequence conflict128-129in Ref. 1; CAA56221
Sequence conflict154in Ref. 1; CAA56221
Sequence conflict200in Ref. 1; CAA56221
Compositional bias219-249Polar residues
Sequence conflict220-236in Ref. 1; CAA56221
Sequence conflict243-251in Ref. 1; CAA56221
Sequence conflict266in Ref. 1; CAA56221
Sequence conflict280-297in Ref. 1; CAA56221

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X79821
EMBL· GenBank· DDBJ
CAA56221.1
EMBL· GenBank· DDBJ
mRNA
AB242331
EMBL· GenBank· DDBJ
BAE48585.1
EMBL· GenBank· DDBJ
mRNA
BX119902
EMBL· GenBank· DDBJ
CAM13211.1
EMBL· GenBank· DDBJ
Genomic DNA
BC078221
EMBL· GenBank· DDBJ
AAH78221.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp