P47792 · SX19A_DANRE
- ProteinTranscription factor Sox-19a
- Genesox19a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids297 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Transcriptional activator.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 53-121 | HMG box | ||||
Sequence: VKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTDAEKRPFIDEAKRLRALHMKEYPDYK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | transcription regulator complex | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | brain development | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | neuron differentiation | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription factor Sox-19a
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionP47792
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048776 | 1-297 | Transcription factor Sox-19a | |||
Sequence: MYSMLEHDMKSAVPPTHQSAQGMTQLNGGVTHGSAKPAVNSQQQQSSDPMDKVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLTDAEKRPFIDEAKRLRALHMKEYPDYKYKPRRKTKPVLKKDNPAAKYPLSAGNLLAAAAAQGSGGSPRMDSYGWGHTGGYPGMQTDALGYSQQLHRYDLSALQYPSAMATAQTYMNGANSYNPMSYSSTPQQPSPVMSMVKPEQVSHSPTGAHSHQRGPLQGDLRDMISMYIPGGDTTDSGAQRGYSNIQQHYLTGTAPLTHI | ||||||
Modified residue | 160 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
PTM databases
Expression
Developmental stage
Expressed zygotically. First detected at the mid-blastula transition. Confined to the future ectoderm by the shield stage, and to the presumptive neuroectoderm by the 75-80% epiboly stage. From the tail bud to the 3-somite stage, expressed throughout the neural plate, except in the anterior margin; strongest expression in the presumptive ventral diencephalon. At the 12- to 25-somite stage, expressed broadly in the central nervous system. From 24-30 hours post-fertilization, restricted to the ventral diencephalon, midbrain and hindbrain/anterior spinal cord region, and to the retina and lens.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-52 | Disordered | ||||
Sequence: MYSMLEHDMKSAVPPTHQSAQGMTQLNGGVTHGSAKPAVNSQQQQSSDPMDK | ||||||
Compositional bias | 14-51 | Polar residues | ||||
Sequence: PPTHQSAQGMTQLNGGVTHGSAKPAVNSQQQQSSDPMD | ||||||
Compositional bias | 219-249 | Polar residues | ||||
Sequence: SYSSTPQQPSPVMSMVKPEQVSHSPTGAHSH | ||||||
Region | 219-255 | Disordered | ||||
Sequence: SYSSTPQQPSPVMSMVKPEQVSHSPTGAHSHQRGPLQ |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length297
- Mass (Da)32,785
- Last updated2006-05-30 v2
- Checksum5990122DC7A953EA
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 14-51 | Polar residues | ||||
Sequence: PPTHQSAQGMTQLNGGVTHGSAKPAVNSQQQQSSDPMD | ||||||
Sequence conflict | 27-33 | in Ref. 1; CAA56221 | ||||
Sequence: NGGVTHG → KRWSDPR | ||||||
Sequence conflict | 39-41 | in Ref. 1; CAA56221 | ||||
Sequence: VNS → CQQ | ||||||
Sequence conflict | 47 | in Ref. 1; CAA56221 | ||||
Sequence: S → R | ||||||
Sequence conflict | 128-129 | in Ref. 1; CAA56221 | ||||
Sequence: TK → Q | ||||||
Sequence conflict | 154 | in Ref. 1; CAA56221 | ||||
Sequence: Missing | ||||||
Sequence conflict | 200 | in Ref. 1; CAA56221 | ||||
Sequence: S → C | ||||||
Compositional bias | 219-249 | Polar residues | ||||
Sequence: SYSSTPQQPSPVMSMVKPEQVSHSPTGAHSH | ||||||
Sequence conflict | 220-236 | in Ref. 1; CAA56221 | ||||
Sequence: YSSTPQQPSPVMSMVKP → IAALHSSPAQSVSHGET | ||||||
Sequence conflict | 243-251 | in Ref. 1; CAA56221 | ||||
Sequence: PTGAHSHQR → SHWSPQPPA | ||||||
Sequence conflict | 266 | in Ref. 1; CAA56221 | ||||
Sequence: I → M | ||||||
Sequence conflict | 280-297 | in Ref. 1; CAA56221 | ||||
Sequence: YSNIQQHYLTGTAPLTHI → LLQHSQHSITGRRLLHTSDQKLSLPSVSGLESHRCRVKMREH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X79821 EMBL· GenBank· DDBJ | CAA56221.1 EMBL· GenBank· DDBJ | mRNA | ||
AB242331 EMBL· GenBank· DDBJ | BAE48585.1 EMBL· GenBank· DDBJ | mRNA | ||
BX119902 EMBL· GenBank· DDBJ | CAM13211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC078221 EMBL· GenBank· DDBJ | AAH78221.1 EMBL· GenBank· DDBJ | mRNA |