P47710 · CASA1_HUMAN
- ProteinAlpha-S1-casein
- GeneCSN1S1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids185 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Important role in the capacity of milk to transport calcium phosphate.
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.
Miscellaneous
In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Biological Process | response to 11-deoxycorticosterone | |
Biological Process | response to dehydroepiandrosterone | |
Biological Process | response to estradiol | |
Biological Process | response to progesterone |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-S1-casein
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP47710
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_048614 | 117 | in dbSNP:rs10030475 | |||
Sequence: A → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 256 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
Protein family/group databases
PTM/Processing
Features
Showing features for signal, chain, modified residue, peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MRLLILTCLVAVALA | ||||||
Chain | PRO_0000004450 | 16-185 | Alpha-S1-casein | |||
Sequence: RPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW | ||||||
Modified residue | 31 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 33 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 41 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 71 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 85 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 86 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 88 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 89 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 90 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 91 | Phosphoserine | ||||
Sequence: S | ||||||
Peptide | PRO_0000004451 | 158-164 | Casoxin-D | |||
Sequence: YVPFPPF |
Post-translational modification
Not glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Mammary gland specific. Secreted in milk.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P47710 | UBQLN2 Q9UHD9 | 3 | EBI-2433045, EBI-947187 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 4 isoforms produced by Alternative splicing.
P47710-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length185
- Mass (Da)21,671
- Last updated1996-02-01 v1
- ChecksumA7717899CDC7D563
P47710-2
- Name2
- Differences from canonical
- 52-52: Missing
P47710-3
- Name3
- Differences from canonical
- 66-73: Missing
P47710-4
- Name4
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D6RF34 | D6RF34_HUMAN | CSN1S1 | 169 | ||
H0Y8K1 | H0Y8K1_HUMAN | CSN1S1 | 76 | ||
A0A0J9YVR3 | A0A0J9YVR3_HUMAN | CSN1S1 | 55 | ||
E9PDQ1 | E9PDQ1_HUMAN | CSN1S1 | 177 |
Features
Showing features for alternative sequence, sequence conflict.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X78416 EMBL· GenBank· DDBJ | CAA55185.1 EMBL· GenBank· DDBJ | mRNA | ||
U23157 EMBL· GenBank· DDBJ | AAA69477.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ064604 EMBL· GenBank· DDBJ | AAY68392.1 EMBL· GenBank· DDBJ | mRNA | ||
AC108941 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471057 EMBL· GenBank· DDBJ | EAX05599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC128227 EMBL· GenBank· DDBJ | AAI28228.1 EMBL· GenBank· DDBJ | mRNA | ||
BC128228 EMBL· GenBank· DDBJ | AAI28229.1 EMBL· GenBank· DDBJ | mRNA | ||
X98084 EMBL· GenBank· DDBJ | CAA66708.1 EMBL· GenBank· DDBJ | mRNA |