P47199 · QOR_MOUSE

  • Protein
    Quinone oxidoreductase
  • Gene
    Cryz
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).

Catalytic activity

Features

Showing features for binding site.

133150100150200250300
TypeIDPosition(s)Description
Binding site53NADP+ (UniProtKB | ChEBI)
Binding site158-161NADP+ (UniProtKB | ChEBI)
Binding site181NADP+ (UniProtKB | ChEBI)
Binding site200NADP+ (UniProtKB | ChEBI)
Binding site231NADP+ (UniProtKB | ChEBI)
Binding site248-251NADP+ (UniProtKB | ChEBI)
Binding site271-273NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionidentical protein binding
Molecular FunctionmRNA 3'-UTR binding
Molecular FunctionNADP binding
Molecular FunctionNADPH binding
Molecular FunctionNADPH:quinone reductase activity
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Functionzinc ion binding
Biological Processprotein homotetramerization
Biological Processxenobiotic catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Quinone oxidoreductase
  • EC number
  • Alternative names
    • NADPH:quinone reductase
    • Zeta-crystallin

Gene names

    • Name
      Cryz

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P47199
  • Secondary accessions
    • Q62508
    • Q99L63

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

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The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00001609082-331Quinone oxidoreductase
Modified residue23N6-acetyllysine
Modified residue35Phosphoserine
Modified residue186N6-acetyllysine
Modified residue298N6-succinyllysine

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    331
  • Mass (Da)
    35,269
  • Last updated
    1995-11-01 v1
  • Checksum
    35816C043EFE16A2
MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPVPQSHQVLIKVHACGVNPVETYIRSGAYSRKPALPYTPGSDVAGIIESVGDKVSAFKKGDRVFCYSTVSGGYAEFALAADDTIYPLPETLNFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKMSVGDKDKGVDVIIEMLANENLSNDLKLLSHGGRVVVVGCRGPIEINPRDTMAKETSIIGVSLSSSTKEEFQQFAGLLQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHGSGKTGKMILLL

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
V9GXY8V9GXY8_MOUSECryz223
A0A0A6YVS7A0A0A6YVS7_MOUSECryz171
A0A0A6YXR4A0A0A6YXR4_MOUSECryz301
D3YUG9D3YUG9_MOUSECryz173
D3YWU6D3YWU6_MOUSECryz97
D3Z4Q4D3Z4Q4_MOUSECryz137
D3Z2X0D3Z2X0_MOUSECryz152
A0A0G2JFU5A0A0G2JFU5_MOUSECryz56

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict58in Ref. 2; AAH03800
Sequence conflict131-133in Ref. 3; BAA11463

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S70056
EMBL· GenBank· DDBJ
AAB30620.2
EMBL· GenBank· DDBJ
mRNA
BC003800
EMBL· GenBank· DDBJ
AAH03800.1
EMBL· GenBank· DDBJ
mRNA
D78646
EMBL· GenBank· DDBJ
BAA11463.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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