P47156 · JHD2_YEAST
- ProteinHistone demethylase JHD2
- GeneJHD2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids728 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'.
Miscellaneous
Present with 290 molecules/cell in log phase SD medium.
Catalytic activity
- 3 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl4-[histone H3] + 3 succinate
3 CHEBI:16810 + RHEA-COMP:15537 CHEBI:61961 Position: 4+ 3 CHEBI:15379 = 3 CHEBI:16526 + 3 CHEBI:16842 + RHEA-COMP:15547 + 3 CHEBI:30031
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | histone H3K4 demethylase activity | |
Molecular Function | histone H3K4me/H3K4me2/H3K4me3 demethylase activity | |
Molecular Function | metal ion binding | |
Biological Process | antisense RNA transcript catabolic process | |
Biological Process | chromatin remodeling | |
Biological Process | mitotic cell cycle | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | rDNA heterochromatin formation | |
Biological Process | regulation of chromatin organization | |
Biological Process | regulation of chromosome condensation | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | sporulation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone demethylase JHD2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP47156
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 427 | Abolishes enzymatic activity. | ||||
Sequence: H → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000203116 | 1-728 | Histone demethylase JHD2 | |||
Sequence: MEEIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPPLSIDMENFTFQPRIQNLENLDLKNRCRLFFMKQLNNFKRSVKDPSKLILREPYTIVEYSDSTHASEILKKKVYFYDVFSELIKDNRTLTDTTQSFRRKLKFRDISQLRGDISLWRTISKKFNVPIGLLKEIFEKYIASYYIFLHSLNENVHTALHADQYPKSLLSDDEDDFDLGPDSNSGSDFEEDDDDACIVCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIVGNGYYGFTQDTHDYSLPEFQEYCKRQNSRLLPARKLSIDELEEMFWSLVTKNRRSSLTTVKYGADIHNELPGQITGFPTREFIPKNINGDELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWHMEDQYTLSANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLISPYDPNFKKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDYKLTQKACVFDMFDLMINVLDKYNKDTLLFNDAFVRQCYSSLIVFYNTELKRIRKIQAIVPRTTLLEVHTDPNDEDEEYDIFCSQCKTICSIAFVLRKNNYDSIRTYKRHKKNHLSIRQWNELSTTDSKVSILCTQDYLKSIQNLNNSDGEEPYIDDELYFTKSLKDIDSLIKQVGVKLDR |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-47 | JmjN | ||||
Sequence: IPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPP | ||||||
Zinc finger | 235-285 | PHD-type | ||||
Sequence: DDACIVCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIVG | ||||||
Domain | 381-549 | JmjC | ||||
Sequence: KYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWHMEDQYTLSANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLISPYDPNFKKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDYK |
Domain
The JmjC domain is required for enzymatic activity.
Sequence similarities
Belongs to the JARID1 histone demethylase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length728
- Mass (Da)84,984
- Last updated1996-02-01 v1
- ChecksumDB22C38B3813F69E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z49619 EMBL· GenBank· DDBJ | CAA89649.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49620 EMBL· GenBank· DDBJ | CAA89651.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08904.1 EMBL· GenBank· DDBJ | Genomic DNA |