P47134 · BIR1_YEAST
- ProteinProtein BIR1
- GeneBIR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids954 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Seems to act in the pleiotropic control of cell division. May participate in chromosome segregation events.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome passenger complex | |
Cellular Component | cytoplasm | |
Cellular Component | kinetochore | |
Cellular Component | microtubule | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | spindle | |
Cellular Component | spindle midzone | |
Molecular Function | metal ion binding | |
Biological Process | apoptotic process | |
Biological Process | attachment of meiotic spindle microtubules to kinetochore | |
Biological Process | cell division | |
Biological Process | chromosome segregation | |
Biological Process | mitotic spindle assembly checkpoint signaling | |
Biological Process | mitotic spindle elongation | |
Biological Process | positive regulation of mitotic cell cycle spindle assembly checkpoint | |
Biological Process | sister chromatid biorientation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein BIR1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP47134
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000122388 | 1-954 | Protein BIR1 | |||
Sequence: MDGQIDKMEKRYSMTKLENRLRTFQDGVALEKKKLKWSFKVIPYQAMAKLGFYFDPVIDPKTSKLKKDSVRCCYCHRQTYNVRDCRSKRKDVLETLSNIMRQHLTVTDNKQVCLLIYLRNKLLTDYSFHMGVSDWKNDKYFSNPDDENVINLRKFTFQDNWPHSGSQNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGWSINDDPMSRHYKVSQNGNCYFFQTRNRFERIKNDNDSITKNCEVSPTLGENGKREVINTKTASQRQCPLFESPPSSTGPQLDDYNEKTDISVIQHNISVLDGAQGENVKRNSVEEKEQINMENGSTTLEEGNINRDVLADKKEVISTPTAKEIKRPNVQLTQSSSPIKKKRKFKRISPRKIFDEEDSEHSLNNNSANGDNKDKDLVIDFTSHIIKNRDVGRKNAILDDSTDEFSFSNQGHNTFDIPIPTSSHLLKGIDSDNDNVIREDDTGINTDTKGASSKHEKFSVNSEEDLNFSEVKLTGRDSSTNILIRTQIVDQNLGDIDRDKVPNGGSPEVPKTHELIRDNSEKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSSNITAIPKEEQRRGNSKTSSIPADIHPKPRKNLQEPRSLSISGKVVPTERKLDNINIDLNFSASDFSPSSQSEQSSKSSSVISTPVASPKINLTRSLHAVKELSGLKKETDDGKYFTNKQETIKILEDVSVKNETPNNEMLLFETGTPIASQENKSRKLFDEEFSGKELDIPIDSSTVEIKKVIKPEFEPVPSVARNLVSGTSSYPRNSRLEEQRKETSTSLADNSKKGSSFNEGNNEKEPNAAEWFKIDENRHLVKNYFHDLLKYINNNDATLANDKDGDLAFLIKQMPAEELDMTFNNWVNLKVQSIKREFIDDCDKKLDILRRDYYTATNFIETLEDDNQLIDIAKKMGIL | ||||||
Modified residue | 477 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 508 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 552 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 587 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 751 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 765 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Strongly interacts with CBF2/NDC10. Also interacts with CBF3D/SKP1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P47134 | IPL1 P38991 | 4 | EBI-3648, EBI-9319 | |
BINARY | P47134 | NBL1 Q3E7Y6 | 5 | EBI-3648, EBI-9513736 | |
BINARY | P47134 | SLI15 P38283 | 8 | EBI-3648, EBI-20842 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 20-117 | BIR 1 | ||||
Sequence: RLRTFQDGVALEKKKLKWSFKVIPYQAMAKLGFYFDPVIDPKTSKLKKDSVRCCYCHRQTYNVRDCRSKRKDVLETLSNIMRQHLTVTDNKQVCLLIY | ||||||
Repeat | 153-241 | BIR 2 | ||||
Sequence: RKFTFQDNWPHSGSQNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGWSINDDPMSRHYKVSQNGNCYFFQ | ||||||
Region | 375-419 | Disordered | ||||
Sequence: NVQLTQSSSPIKKKRKFKRISPRKIFDEEDSEHSLNNNSANGDNK | ||||||
Region | 541-645 | Disordered | ||||
Sequence: DIDRDKVPNGGSPEVPKTHELIRDNSEKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSSNITAIPKEEQRRGNSKTSSIPADIHPKPRKNLQEPRSLSISGKV | ||||||
Compositional bias | 557-585 | Basic and acidic residues | ||||
Sequence: KTHELIRDNSEKREAQNGEFRHQKDSTVR | ||||||
Compositional bias | 586-609 | Polar residues | ||||
Sequence: QSPDILHSNKSGDNSSNITAIPKE | ||||||
Region | 661-685 | Disordered | ||||
Sequence: FSASDFSPSSQSEQSSKSSSVISTP | ||||||
Region | 798-839 | Disordered | ||||
Sequence: LVSGTSSYPRNSRLEEQRKETSTSLADNSKKGSSFNEGNNEK | ||||||
Compositional bias | 823-838 | Polar residues | ||||
Sequence: ADNSKKGSSFNEGNNE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length954
- Mass (Da)108,667
- Last updated1996-02-01 v1
- Checksum6B20DC16065B4C39
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 557-585 | Basic and acidic residues | ||||
Sequence: KTHELIRDNSEKREAQNGEFRHQKDSTVR | ||||||
Compositional bias | 586-609 | Polar residues | ||||
Sequence: QSPDILHSNKSGDNSSNITAIPKE | ||||||
Compositional bias | 823-838 | Polar residues | ||||
Sequence: ADNSKKGSSFNEGNNE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z49589 EMBL· GenBank· DDBJ | CAA89616.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L47993 EMBL· GenBank· DDBJ | AAB39312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08873.1 EMBL· GenBank· DDBJ | Genomic DNA |