P47116 · PTK2_YEAST

Function

function

Essential determinant for high-affinity spermidine transport. Required for the activation of the plasma membrane proton pump PMA1 via phosphorylation of 'Ser-899'.

Miscellaneous

Present with 1420 molecules/cell in log phase SD medium.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site261-269ATP (UniProtKB | ChEBI)
Binding site285ATP (UniProtKB | ChEBI)
Active site388Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionprotein kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processintracellular monoatomic ion homeostasis
Biological Processputrescine transport
Biological Processregulation of cell size
Biological Processspermidine transport
Biological Processspermine transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase PTK2/STK2
  • EC number

Gene names

    • Name
      PTK2
    • Synonyms
      STK2
    • ORF names
      J1725
    • Ordered locus names
      YJR059W

Organism names

Accessions

  • Primary accession
    P47116
  • Secondary accessions
    • D6VWN0
    • E9P962

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000865911-818Serine/threonine-protein kinase PTK2/STK2
Modified residue56Phosphothreonine
Modified residue59Phosphoserine
Modified residue80Phosphoserine
Modified residue623Phosphoserine
Modified residue632Phosphoserine
Modified residue694Phosphoserine
Modified residue700Phosphothreonine
Modified residue711Phosphoserine
Modified residue737Phosphothreonine
Modified residue752Phosphoserine
Modified residue755Phosphoserine
Modified residue778Phosphoserine
Modified residue781Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region28-100Disordered
Compositional bias117-131Polar residues
Region117-177Disordered
Compositional bias138-163Basic and acidic residues
Domain255-562Protein kinase
Region585-795Disordered
Compositional bias633-687Basic and acidic residues
Compositional bias688-706Polar residues
Compositional bias756-790Polar residues

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    818
  • Mass (Da)
    91,400
  • Last updated
    1996-02-01 v1
  • Checksum
    55B6C882894FB4BD
MAGNGKDKEVDKSPSVSTLKLLGKRLFNSSSHTDNSSLLLSAEQLGNGRSLRKRPTSPSISGSGSGGNSPSSSAGARQRSASLHRRKNNASVGFSNGSVSSHKSSVALQDLIKHNNNPYLNSPSDILGTGTGIASTRDRDRAVLDREKEKERARNKERNTHHAGLPQRSNSMASHHFPNENIVYNPYGISPNHARPDTAFADTLNTNKENDLSFYMHDGNSKIRMLPLPIANPNDFLPEDMKQYSVHLTDNFVFDTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFFQQIETCVEPNDDDLVRVPELRKSTSTNDFSENSLDAPHDQEVIHTSNPFLKKETLTSKPRSMLEIAESPSLKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEATTTNVDSILEKPTPTSTKVEDNLSEDDSTMKELKSMLNSTPTTPTHNGPTPLPAKAGTQLDKRMSDLSLKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSSKKKKVIHHHLDITNSVTNMSSVSAFISR

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias117-131Polar residues
Compositional bias138-163Basic and acidic residues
Compositional bias633-687Basic and acidic residues
Compositional bias688-706Polar residues
Compositional bias756-790Polar residues
Sequence conflict801in Ref. 5; AAU09754

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D87274
EMBL· GenBank· DDBJ
BAA13325.1
EMBL· GenBank· DDBJ
Genomic DNA
Z49559
EMBL· GenBank· DDBJ
CAA89587.1
EMBL· GenBank· DDBJ
Genomic DNA
L47993
EMBL· GenBank· DDBJ
AAB39285.1
EMBL· GenBank· DDBJ
Genomic DNA
AY723837
EMBL· GenBank· DDBJ
AAU09754.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006943
EMBL· GenBank· DDBJ
DAA08846.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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