P47116 · PTK2_YEAST
- ProteinSerine/threonine-protein kinase PTK2/STK2
- GenePTK2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids818 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Essential determinant for high-affinity spermidine transport. Required for the activation of the plasma membrane proton pump PMA1 via phosphorylation of 'Ser-899'.
Miscellaneous
Present with 1420 molecules/cell in log phase SD medium.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | G1/S transition of mitotic cell cycle | |
Biological Process | intracellular monoatomic ion homeostasis | |
Biological Process | putrescine transport | |
Biological Process | regulation of cell size | |
Biological Process | spermidine transport | |
Biological Process | spermine transport |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase PTK2/STK2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP47116
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086591 | 1-818 | Serine/threonine-protein kinase PTK2/STK2 | |||
Sequence: MAGNGKDKEVDKSPSVSTLKLLGKRLFNSSSHTDNSSLLLSAEQLGNGRSLRKRPTSPSISGSGSGGNSPSSSAGARQRSASLHRRKNNASVGFSNGSVSSHKSSVALQDLIKHNNNPYLNSPSDILGTGTGIASTRDRDRAVLDREKEKERARNKERNTHHAGLPQRSNSMASHHFPNENIVYNPYGISPNHARPDTAFADTLNTNKENDLSFYMHDGNSKIRMLPLPIANPNDFLPEDMKQYSVHLTDNFVFDTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFFQQIETCVEPNDDDLVRVPELRKSTSTNDFSENSLDAPHDQEVIHTSNPFLKKETLTSKPRSMLEIAESPSLKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEATTTNVDSILEKPTPTSTKVEDNLSEDDSTMKELKSMLNSTPTTPTHNGPTPLPAKAGTQLDKRMSDLSLKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSSKKKKVIHHHLDITNSVTNMSSVSAFISR | ||||||
Modified residue | 56 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 59 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 80 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 623 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 632 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 694 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 700 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 711 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 737 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 752 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 755 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 778 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 781 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 28-100 | Disordered | ||||
Sequence: NSSSHTDNSSLLLSAEQLGNGRSLRKRPTSPSISGSGSGGNSPSSSAGARQRSASLHRRKNNASVGFSNGSVS | ||||||
Compositional bias | 117-131 | Polar residues | ||||
Sequence: NPYLNSPSDILGTGT | ||||||
Region | 117-177 | Disordered | ||||
Sequence: NPYLNSPSDILGTGTGIASTRDRDRAVLDREKEKERARNKERNTHHAGLPQRSNSMASHHF | ||||||
Compositional bias | 138-163 | Basic and acidic residues | ||||
Sequence: DRDRAVLDREKEKERARNKERNTHHA | ||||||
Domain | 255-562 | Protein kinase | ||||
Sequence: DTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFF | ||||||
Region | 585-795 | Disordered | ||||
Sequence: STSTNDFSENSLDAPHDQEVIHTSNPFLKKETLTSKPRSMLEIAESPSLKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEATTTNVDSILEKPTPTSTKVEDNLSEDDSTMKELKSMLNSTPTTPTHNGPTPLPAKAGTQLDKRMSDLSLKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSSKKKKV | ||||||
Compositional bias | 633-687 | Basic and acidic residues | ||||
Sequence: LKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEA | ||||||
Compositional bias | 688-706 | Polar residues | ||||
Sequence: TTTNVDSILEKPTPTSTKV | ||||||
Compositional bias | 756-790 | Polar residues | ||||
Sequence: LKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSS |
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length818
- Mass (Da)91,400
- Last updated1996-02-01 v1
- Checksum55B6C882894FB4BD
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 117-131 | Polar residues | ||||
Sequence: NPYLNSPSDILGTGT | ||||||
Compositional bias | 138-163 | Basic and acidic residues | ||||
Sequence: DRDRAVLDREKEKERARNKERNTHHA | ||||||
Compositional bias | 633-687 | Basic and acidic residues | ||||
Sequence: LKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEA | ||||||
Compositional bias | 688-706 | Polar residues | ||||
Sequence: TTTNVDSILEKPTPTSTKV | ||||||
Compositional bias | 756-790 | Polar residues | ||||
Sequence: LKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSS | ||||||
Sequence conflict | 801 | in Ref. 5; AAU09754 | ||||
Sequence: D → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D87274 EMBL· GenBank· DDBJ | BAA13325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49559 EMBL· GenBank· DDBJ | CAA89587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L47993 EMBL· GenBank· DDBJ | AAB39285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY723837 EMBL· GenBank· DDBJ | AAU09754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08846.1 EMBL· GenBank· DDBJ | Genomic DNA |