P47110 · DPOD3_YEAST
- ProteinDNA polymerase delta subunit 3
- GenePOL32
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids350 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.
Miscellaneous
Present with 2410 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | delta DNA polymerase complex | |
Cellular Component | nucleus | |
Cellular Component | zeta DNA polymerase complex | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | H3-H4 histone complex chaperone activity | |
Biological Process | base-excision repair | |
Biological Process | DNA amplification | |
Biological Process | DNA metabolic process | |
Biological Process | DNA replication, removal of RNA primer | |
Biological Process | double-strand break repair via break-induced replication | |
Biological Process | error-prone translesion synthesis | |
Biological Process | lagging strand elongation | |
Biological Process | leading strand elongation | |
Biological Process | nucleotide-excision repair | |
Biological Process | RNA-templated DNA biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase delta subunit 3
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP47110
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000186050 | 1-350 | DNA polymerase delta subunit 3 | |||
Sequence: MDQKASYFINEKLFTEVKPVLFTDLIHHLKIGPSMAKKLMFDYYKQTTNAKYNCVVICCYKDQTIKIIHDLSNIPQQDSIIDCFIYAFNPMDSFIPYYDIIDQKDCLTIKNSYELKVSESSKIIERTKTLEEKSKPLVRPTARSKTTPEETTGRKSKSKDMGLRSTALLAKMKKDRDDKETSRQNELRKRKEENLQKINKQNPEREAQMKELNNLFVEDDLDTEEVNGGSKPNSPKETDSNDKDKNNDDLEDLLETTAEDSLMDVPKIQQTKPSETEHSKEPKSEEEPSSFIDEDGYIVTKRPATSTPPRKPSPVVKRALSSSKKQETPSSNKRLKKQGTLESFFKRKAK | ||||||
Modified residue | 223 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 230 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
DNA polymerase delta is a heterotrimer of POL3, POL32 and HYS2. POL32 can form homodimers.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P47110 | POL30 P15873 | 4 | EBI-6084, EBI-12993 | |
BINARY | P47110 | REV1 P12689 | 4 | EBI-6084, EBI-14951 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 131-350 | Disordered | ||||
Sequence: EEKSKPLVRPTARSKTTPEETTGRKSKSKDMGLRSTALLAKMKKDRDDKETSRQNELRKRKEENLQKINKQNPEREAQMKELNNLFVEDDLDTEEVNGGSKPNSPKETDSNDKDKNNDDLEDLLETTAEDSLMDVPKIQQTKPSETEHSKEPKSEEEPSSFIDEDGYIVTKRPATSTPPRKPSPVVKRALSSSKKQETPSSNKRLKKQGTLESFFKRKAK | ||||||
Compositional bias | 169-217 | Basic and acidic residues | ||||
Sequence: LAKMKKDRDDKETSRQNELRKRKEENLQKINKQNPEREAQMKELNNLFV | ||||||
Compositional bias | 236-252 | Basic and acidic residues | ||||
Sequence: KETDSNDKDKNNDDLED | ||||||
Compositional bias | 271-290 | Basic and acidic residues | ||||
Sequence: TKPSETEHSKEPKSEEEPSS | ||||||
Compositional bias | 319-338 | Polar residues | ||||
Sequence: ALSSSKKQETPSSNKRLKKQ |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length350
- Mass (Da)40,310
- Last updated1996-02-01 v1
- ChecksumD0B9CC52F26E20B2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 169-217 | Basic and acidic residues | ||||
Sequence: LAKMKKDRDDKETSRQNELRKRKEENLQKINKQNPEREAQMKELNNLFV | ||||||
Compositional bias | 236-252 | Basic and acidic residues | ||||
Sequence: KETDSNDKDKNNDDLED | ||||||
Compositional bias | 271-290 | Basic and acidic residues | ||||
Sequence: TKPSETEHSKEPKSEEEPSS | ||||||
Compositional bias | 319-338 | Polar residues | ||||
Sequence: ALSSSKKQETPSSNKRLKKQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L36344 EMBL· GenBank· DDBJ | AAA88745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49543 EMBL· GenBank· DDBJ | CAA89571.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY557918 EMBL· GenBank· DDBJ | AAS56244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08830.1 EMBL· GenBank· DDBJ | Genomic DNA |