P47110 · DPOD3_YEAST

Function

function

DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.

Miscellaneous

Present with 2410 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdelta DNA polymerase complex
Cellular Componentnucleus
Cellular Componentzeta DNA polymerase complex
Molecular FunctionDNA-directed DNA polymerase activity
Molecular FunctionH3-H4 histone complex chaperone activity
Biological Processbase-excision repair
Biological ProcessDNA amplification
Biological ProcessDNA metabolic process
Biological ProcessDNA replication, removal of RNA primer
Biological Processdouble-strand break repair via break-induced replication
Biological Processerror-prone translesion synthesis
Biological Processlagging strand elongation
Biological Processleading strand elongation
Biological Processnucleotide-excision repair
Biological ProcessRNA-templated DNA biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase delta subunit 3

Gene names

    • Name
      POL32
    • ORF names
      J1626
    • Ordered locus names
      YJR043C

Organism names

Accessions

  • Primary accession
    P47110
  • Secondary accessions
    • D6VWL4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001860501-350DNA polymerase delta subunit 3
Modified residue223Phosphothreonine
Modified residue230Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

DNA polymerase delta is a heterotrimer of POL3, POL32 and HYS2. POL32 can form homodimers.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P47110POL30 P158734EBI-6084, EBI-12993
BINARY P47110REV1 P126894EBI-6084, EBI-14951

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region131-350Disordered
Compositional bias169-217Basic and acidic residues
Compositional bias236-252Basic and acidic residues
Compositional bias271-290Basic and acidic residues
Compositional bias319-338Polar residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    350
  • Mass (Da)
    40,310
  • Last updated
    1996-02-01 v1
  • Checksum
    D0B9CC52F26E20B2
MDQKASYFINEKLFTEVKPVLFTDLIHHLKIGPSMAKKLMFDYYKQTTNAKYNCVVICCYKDQTIKIIHDLSNIPQQDSIIDCFIYAFNPMDSFIPYYDIIDQKDCLTIKNSYELKVSESSKIIERTKTLEEKSKPLVRPTARSKTTPEETTGRKSKSKDMGLRSTALLAKMKKDRDDKETSRQNELRKRKEENLQKINKQNPEREAQMKELNNLFVEDDLDTEEVNGGSKPNSPKETDSNDKDKNNDDLEDLLETTAEDSLMDVPKIQQTKPSETEHSKEPKSEEEPSSFIDEDGYIVTKRPATSTPPRKPSPVVKRALSSSKKQETPSSNKRLKKQGTLESFFKRKAK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias169-217Basic and acidic residues
Compositional bias236-252Basic and acidic residues
Compositional bias271-290Basic and acidic residues
Compositional bias319-338Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L36344
EMBL· GenBank· DDBJ
AAA88745.1
EMBL· GenBank· DDBJ
Genomic DNA
Z49543
EMBL· GenBank· DDBJ
CAA89571.1
EMBL· GenBank· DDBJ
Genomic DNA
AY557918
EMBL· GenBank· DDBJ
AAS56244.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006943
EMBL· GenBank· DDBJ
DAA08830.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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