P47058 · TAD2_YEAST
- ProteintRNA-specific adenosine deaminase subunit TAD2
- GeneTAD2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids250 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Deaminates adenosine-34 to inosine in many tRNAs.
Miscellaneous
Present with 830 molecules/cell in log phase SD medium.
Catalytic activity
- adenosine34 in tRNA + H+ + H2O = inosine34 in tRNA + NH4+
RHEA-COMP:10373 CHEBI:74411 Position: 34+ CHEBI:15378 + CHEBI:15377 = RHEA-COMP:10374 CHEBI:82852 Position: 34+ CHEBI:28938
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | tRNA-specific adenosine-34 deaminase complex | |
Molecular Function | tRNA-specific adenosine deaminase activity | |
Molecular Function | tRNA-specific adenosine-34 deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | tRNA modification | |
Biological Process | tRNA wobble adenosine to inosine editing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA-specific adenosine deaminase subunit TAD2
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP47058
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000171740 | 1-250 | tRNA-specific adenosine deaminase subunit TAD2 | |||
Sequence: MQHIKHMRTAVRLARYALDHDETPVACIFVHTPTGQVMAYGMNDTNKSLTGVAHAEFMGIDQIKAMLGSRGVVDVFKDITLYVTVEPCIMCASALKQLDIGKVVFGCGNERFGGNGTVLSVNHDTCTLVPKNNSAAGYESIPGILRKEAIMLLRYFYVRQNERAPKPRSKSDRVLDKNTFPPMEWSKYLNEEAFIETFGDDYRTCFANKVDLSSNSVDWDLIDSHQDNIIQELEEQCKMFKFNVHKKSKV |
Proteomic databases
Interaction
Subunit
Heterodimer with TAD3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P47058 | TAD3 Q9URQ3 | 3 | EBI-18939, EBI-2094330 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-119 | CMP/dCMP-type deaminase | ||||
Sequence: MQHIKHMRTAVRLARYALDHDETPVACIFVHTPTGQVMAYGMNDTNKSLTGVAHAEFMGIDQIKAMLGSRGVVDVFKDITLYVTVEPCIMCASALKQLDIGKVVFGCGNERFGGNGTVL |
Sequence similarities
Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length250
- Mass (Da)28,252
- Last updated1996-02-01 v1
- ChecksumC774A1E50AA68106
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ242667 EMBL· GenBank· DDBJ | CAB60629.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49310 EMBL· GenBank· DDBJ | CAA89326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY693172 EMBL· GenBank· DDBJ | AAT93191.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z48229 EMBL· GenBank· DDBJ | CAA88261.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
BK006943 EMBL· GenBank· DDBJ | DAA08764.1 EMBL· GenBank· DDBJ | Genomic DNA |