P46999 · PIR5_YEAST
- ProteinCell wall protein PIR5
- GenePIR5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids287 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of the outer cell wall layer (By similarity).
May be involved in meiosis and sporulation
May be involved in meiosis and sporulation
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 62-63 | Cleavage; by KEX2 | ||||
Sequence: RN | ||||||
Site | 72 | Covalent attachment to cell wall glycan | ||||
Sequence: Q | ||||||
Site | 91 | Covalent attachment to cell wall glycan | ||||
Sequence: Q | ||||||
Site | 114 | Covalent attachment to cell wall glycan | ||||
Sequence: Q | ||||||
Site | 154 | Covalent attachment to cell wall glycan | ||||
Sequence: Q |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | fungal-type cell wall | |
Cellular Component | fungal-type vacuole | |
Molecular Function | structural constituent of cell wall | |
Biological Process | fungal-type cell wall organization |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCell wall protein PIR5
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP46999
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Covalently attached to the cell wall.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, propeptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MHYKKAFLASLLSSIALTAYA | ||||||
Propeptide | PRO_0000377623 | 22-62 | ||||
Sequence: PPEPWATLTPSSKMDGGTTEYRTSFGLAVIPFTVTESKVKR | ||||||
Chain | PRO_0000014333 | 63-287 | Cell wall protein PIR5 | |||
Sequence: NVISQINDGQVQVTTQKLPHPVSQIGDGQIQVTTQKVPPVVSHIVSQIGDGQLQITTAKNVVTKSTIAVPSKTVTATATSTATAVSQIHDGQVQVTISSASSSSVLSKSKLEPTKKPNNEKVIKVQACKSSGTLAITLQGGVLIDSSGRIGSIVANRQFQFDGPPPQAGAIYAGGWSITKHGTLAIGDNDVFYQCLSGTFYNLYDQSIGGQCNPVHLQTVGLVDC |
Post-translational modification
Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
Keywords
- PTM
Proteomic databases
Expression
Induction
Cell cycle-regulated. Expression peaks during mitosis.
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 62-80 | PIR1/2/3 1 | ||||
Sequence: RNVISQINDGQVQVTTQKL | ||||||
Repeat | 81-99 | PIR1/2/3 2 | ||||
Sequence: PHPVSQIGDGQIQVTTQKV | ||||||
Repeat | 104-122 | PIR1/2/3 3 | ||||
Sequence: SHIVSQIGDGQLQITTAKN | ||||||
Repeat | 144-162 | PIR1/2/3 4 | ||||
Sequence: ATAVSQIHDGQVQVTISSA |
Domain
The PIR1/2/3 repeats are required for the covalent linkage to the cell wall (By similarity).
Their number varies among different strains of S.cerevisiae
Their number varies among different strains of S.cerevisiae
Sequence similarities
Belongs to the PIR protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length287
- Mass (Da)30,215
- Last updated2006-05-16 v2
- Checksum3E02845EA0DD7F33
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z49435 EMBL· GenBank· DDBJ | CAA89455.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift | |
AY260893 EMBL· GenBank· DDBJ | AAP21761.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006943 EMBL· GenBank· DDBJ | DAA08643.1 EMBL· GenBank· DDBJ | Genomic DNA |