P46778 · RL21_HUMAN
- ProteinLarge ribosomal subunit protein eL21
- GeneRPL21
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids160 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | cytosolic large ribosomal subunit | |
Cellular Component | cytosolic ribosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Cellular Component | synapse | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | cytoplasmic translation | |
Biological Process | translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLarge ribosomal subunit protein eL21
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP46778
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Detected on cytosolic polysomes (PubMed:25957688).
Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Hypotrichosis 12 (HYPT12)
- Note
- DescriptionA form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent. HYPT12 inheritance is autosomal dominant.
- See alsoMIM:615885
Natural variants in HYPT12
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_066030 | 32 | R>Q | in HYPT12; autosomal dominant; dbSNP:rs587777527 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034459 | 15 | in dbSNP:rs17085349 | |||
Sequence: F → S | ||||||
Natural variant | VAR_066030 | 32 | in HYPT12; autosomal dominant; dbSNP:rs587777527 | |||
Sequence: R → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 141 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000149669 | 2-160 | Large ribosomal subunit protein eL21 | |||
Sequence: TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 112-145 | Disordered | ||||
Sequence: NDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNG |
Sequence similarities
Belongs to the eukaryotic ribosomal protein eL21 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length160
- Mass (Da)18,565
- Last updated2007-01-23 v2
- ChecksumC51D0B5E8EB9D69E
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 72 | in Ref. 2; AAA93231 | ||||
Sequence: V → A | ||||||
Sequence conflict | 78 | in Ref. 2; AAA93231 | ||||
Sequence: K → E | ||||||
Sequence conflict | 104 | in Ref. 2; AAA93231 | ||||
Sequence: S → N | ||||||
Sequence conflict | 112 | in Ref. 2; AAA93231 | ||||
Sequence: N → D | ||||||
Sequence conflict | 115 | in Ref. 2; AAA93231 | ||||
Sequence: K → E | ||||||
Sequence conflict | 120 | in Ref. 2; AAA93231 | ||||
Sequence: K → Q | ||||||
Sequence conflict | 131 | in Ref. 5; AAA80462 | ||||
Sequence: Q → H |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X89401 EMBL· GenBank· DDBJ | CAA61582.1 EMBL· GenBank· DDBJ | mRNA | ||
U14967 EMBL· GenBank· DDBJ | AAA85655.1 EMBL· GenBank· DDBJ | mRNA | ||
AB061826 EMBL· GenBank· DDBJ | BAB79464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC001603 EMBL· GenBank· DDBJ | AAH01603.1 EMBL· GenBank· DDBJ | mRNA | ||
BC007505 EMBL· GenBank· DDBJ | AAH07505.1 EMBL· GenBank· DDBJ | mRNA | ||
BC062981 EMBL· GenBank· DDBJ | AAH62981.1 EMBL· GenBank· DDBJ | mRNA | ||
BC070184 EMBL· GenBank· DDBJ | AAH70184.1 EMBL· GenBank· DDBJ | mRNA | ||
BC070323 EMBL· GenBank· DDBJ | AAH70323.1 EMBL· GenBank· DDBJ | mRNA | ||
BC070330 EMBL· GenBank· DDBJ | AAH70330.1 EMBL· GenBank· DDBJ | mRNA | ||
U25789 EMBL· GenBank· DDBJ | AAA93231.1 EMBL· GenBank· DDBJ | mRNA | ||
L38826 EMBL· GenBank· DDBJ | AAA80462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB007176 EMBL· GenBank· DDBJ | BAA25835.1 EMBL· GenBank· DDBJ | Genomic DNA |