P46701 · PURK_MYCLE

Function

function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Features

Showing features for binding site.

143950100150200250300350400
TypeIDPosition(s)Description
Binding site113ATP (UniProtKB | ChEBI)
Binding site160ATP (UniProtKB | ChEBI)
Binding site197-200ATP (UniProtKB | ChEBI)
Binding site205ATP (UniProtKB | ChEBI)
Binding site283-284ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-(carboxyamino)imidazole ribonucleotide synthase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylaminoimidazole carboxylase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N5-carboxyaminoimidazole ribonucleotide synthase
  • EC number
  • Short names
    N5-CAIR synthase
  • Alternative names
    • 5-(carboxyamino)imidazole ribonucleotide synthetase

Gene names

    • Name
      purK
    • ORF names
      B1308_F1_32
    • Ordered locus names
      ML0735

Organism names

Accessions

  • Primary accession
    P46701

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000749991-439N5-carboxyaminoimidazole ribonucleotide synthase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain117-313ATP-grasp

Sequence similarities

Belongs to the PurK/PurT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    439
  • Mass (Da)
    47,306
  • Last updated
    1995-11-01 v1
  • Checksum
    288C5DD5EE7508EE
MMAVPSRCSLGVAPLVAMVGGGQLARMTHQAAIALGQTLRVLATAADEPAAQVTPDVVIGSHTDLEDLRRVALGADALTFDHEHVPTELLDKLVAEGINVAPSPQALVHAQDKLVMRRRLAALGAAMPRFMALDSVDDLAEIDAFAQRLTGSKDAPMVVKAVRGGYDGRGVQMVRDSAHAREVASGYLVDGMPVLVEERVELRRELSALVARSPFGQGAAWPVVETVQRDGICVLVVAPALALADDLASAAQQLALRLAAELGVVGVFAVELFETADGALLVNELAMRPHNSGHWTMDGARTSQFEQHLRAVLDYPLGETDAVAPVTVMVNVLGAPQPPTLSVVTMDERLHHLFARMPDARVHLYDKVERPGRKVGHINFRGTDKDRKNPTKLRERAELAAHWLSHGQWTDGWDPHRAGDDVVEISLACGGRNDAQRQR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U00012
EMBL· GenBank· DDBJ
AAA85935.1
EMBL· GenBank· DDBJ
Genomic DNA
AL583919
EMBL· GenBank· DDBJ
CAC30244.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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