P46694 · IEX1_MOUSE

  • Protein
    Radiation-inducible immediate-early gene IEX-1
  • Gene
    Ier3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity).
As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Cellular Componentnucleus
Biological ProcessDNA damage response
Biological Processglycolytic process
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processmitotic G2 DNA damage checkpoint signaling
Biological Processnegative regulation of glycolytic process
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Biological Processnegative regulation of systemic arterial blood pressure
Biological Processpositive regulation of protein catabolic process
Biological Processregulation of DNA repair
Biological Processregulation of nucleocytoplasmic transport
Biological Processregulation of reactive oxygen species metabolic process
Biological Processresponse to protozoan

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Radiation-inducible immediate-early gene IEX-1
  • Alternative names
    • Immediate early protein GLY96
    • Immediate early response 3 protein

Gene names

    • Name
      Ier3
    • Synonyms
      Gly96, Iex1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • 129/SvJ
    • C57BL/6J
    • NOD
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P46694
  • Secondary accessions
    • Q4FJY1
    • Q91VZ5

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-85Cytoplasmic
Transmembrane86-102Helical; Signal-anchor for type II membrane protein
Topological domain103-153Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000841601-160Radiation-inducible immediate-early gene IEX-1
Modified residue31Phosphoserine
Glycosylation137N-linked (GlcNAc...) asparagine

Post-translational modification

Glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed predominantly in the lung, testes and the uterus.

Induction

By serum growth factors and TPA.

Gene expression databases

Interaction

Subunit

Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-35Disordered

Sequence similarities

Belongs to the IER3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    160
  • Mass (Da)
    17,655
  • Last updated
    2022-02-23 v2
  • Checksum
    0666DF96E751FCF4
MCHSRNHLHTMTGLRAPSPAPSTGPELRRGSGPEIFTFDPLPERAVVSTARLNTSRGHRKRSRRVLYPRVVRRQLPTEEPNIAKRVLFLLFAIIFCQILMAEEGVSQPLAPEDATSAVTPEPISAPITAPPVLEPLNLTSESSDYALDLKAFLQQHPAAF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict134in Ref. 4; CAJ18479

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X67644
EMBL· GenBank· DDBJ
-mRNA No translation available.
AY168443
EMBL· GenBank· DDBJ
AAO39405.1
EMBL· GenBank· DDBJ
Genomic DNA
AK051003
EMBL· GenBank· DDBJ
BAC34493.1
EMBL· GenBank· DDBJ
mRNA
AK170477
EMBL· GenBank· DDBJ
BAE41821.1
EMBL· GenBank· DDBJ
mRNA
CT010247
EMBL· GenBank· DDBJ
CAJ18455.1
EMBL· GenBank· DDBJ
mRNA
CT010271
EMBL· GenBank· DDBJ
CAJ18479.1
EMBL· GenBank· DDBJ
mRNA
GL456179
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC006950
EMBL· GenBank· DDBJ
AAH06950.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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