P46639 · KNAT1_ARATH
- ProteinHomeobox protein knotted-1-like 1
- GeneKNAT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids398 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play a role in meristem function, and may be involved in maintaining cells in an undifferentiated, meristematic state, and its expression disappears at the same time the shoot apex undergoes the transition from vegetative to reproductive development (PubMed:11934861).
Positive regulator of LATERAL ORGAN BOUNDARIES (LOB) (PubMed:11934861).
Probably binds to the DNA sequence 5'-TGAC-3' (PubMed:11934861).
Able to traffic from the L1 to the L2/L3 layers of the meristem, presumably through plasmodesmata (PubMed:12900451).
Positive regulator of LATERAL ORGAN BOUNDARIES (LOB) (PubMed:11934861).
Probably binds to the DNA sequence 5'-TGAC-3' (PubMed:11934861).
Able to traffic from the L1 to the L2/L3 layers of the meristem, presumably through plasmodesmata (PubMed:12900451).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 300-363 | Homeobox; TALE-type | ||||
Sequence: SKKKKKGKLPKEARQKLLTWWELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKRHWKPS |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | identical protein binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | cell fate commitment | |
Biological Process | cell fate specification | |
Biological Process | xylem and phloem pattern formation | |
Biological Process | xylem development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameHomeobox protein knotted-1-like 1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP46639
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048957 | 1-398 | Homeobox protein knotted-1-like 1 | |||
Sequence: MEEYQHDNSTTPQRVSFLYSPISSSNKNDNTSDTNNNNNNNNSSNYGPGYNNTNNNNHHHQHMLFPHMSSLLPQTTENCFRSDHDQPNNNNNPSVKSEASSSRINHYSMLMRAIHNTQEANNNNNDNVSDVEAMKAKIIAHPHYSTLLQAYLDCQKIGAPPDVVDRITAARQDFEARQQRSTPSVSASSRDPELDQFMEAYCDMLVKYREELTRPIQEAMEFIRRIESQLSMLCQSPIHILNNPDGKSDNMGSSDEEQENNSGGETELPEIDPRAEDRELKNHLLKKYSGYLSSLKQELSKKKKKGKLPKEARQKLLTWWELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKRHWKPSEDMQFMVMDGLQHPHHAALYMDGHYMGDGPYRLGP |
Proteomic databases
Expression
Tissue specificity
Expressed in the vegetative meristem. Present in the base of flower primordia (PubMed:26390296).
Induction
Negatively regulated by ASYMMETRIC LEAVES1 (AS1) and ASYMMETRIC LEAVES2 (AS2).
Gene expression databases
Interaction
Subunit
May form heterodimeric complex with the TALE/BELL proteins BEL1, BLH2, BLH8/PNF and BLH9/PNY (PubMed:11701881, PubMed:12897247, PubMed:16741748, PubMed:17873098).
Interacts with OFP1, OFP2, OFP4, OFP6 and OFP12 (PubMed:15781858).
Interacts with CCT7 and CCT8 (PubMed:21868675).
Interacts with KNATM-B (PubMed:18398054).
Binds to AGO10/PNH (PubMed:26390296).
Interacts with BZIP30 (PubMed:27402171).
Interacts with OFP1, OFP2, OFP4, OFP6 and OFP12 (PubMed:15781858).
Interacts with CCT7 and CCT8 (PubMed:21868675).
Interacts with KNATM-B (PubMed:18398054).
Binds to AGO10/PNH (PubMed:26390296).
Interacts with BZIP30 (PubMed:27402171).
Binary interactions
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 20-61 | Disordered | ||||
Sequence: SPISSSNKNDNTSDTNNNNNNNNSSNYGPGYNNTNNNNHHHQ | ||||||
Region | 78-102 | Disordered | ||||
Sequence: NCFRSDHDQPNNNNNPSVKSEASSS | ||||||
Compositional bias | 241-259 | Polar residues | ||||
Sequence: LNNPDGKSDNMGSSDEEQE | ||||||
Region | 241-273 | Disordered | ||||
Sequence: LNNPDGKSDNMGSSDEEQENNSGGETELPEIDP | ||||||
Domain | 279-299 | ELK | ||||
Sequence: ELKNHLLKKYSGYLSSLKQEL |
Sequence similarities
Belongs to the TALE/KNOX homeobox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length398
- Mass (Da)45,836
- Last updated1995-11-01 v1
- Checksum815A22786589A316
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 10 | in Ref. 2; AAM03027/AAM03026 | ||||
Sequence: T → S | ||||||
Sequence conflict | 77 | in Ref. 2; AAM03026 | ||||
Sequence: E → D | ||||||
Sequence conflict | 92 | in Ref. 2; AAM03027/AAM03026 | ||||
Sequence: N → NN | ||||||
Sequence conflict | 125 | in Ref. 2; AAM03027/AAM03026 | ||||
Sequence: N → NN | ||||||
Compositional bias | 241-259 | Polar residues | ||||
Sequence: LNNPDGKSDNMGSSDEEQE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U14174 EMBL· GenBank· DDBJ | AAA67881.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF482994 EMBL· GenBank· DDBJ | AAM03026.1 EMBL· GenBank· DDBJ | mRNA | ||
AF482995 EMBL· GenBank· DDBJ | AAM03027.1 EMBL· GenBank· DDBJ | mRNA | ||
AC006267 EMBL· GenBank· DDBJ | AAD27897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161510 EMBL· GenBank· DDBJ | CAB81151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY080834 EMBL· GenBank· DDBJ | AAL87309.1 EMBL· GenBank· DDBJ | mRNA | ||
AY113982 EMBL· GenBank· DDBJ | AAM45030.1 EMBL· GenBank· DDBJ | mRNA |