P46436 · GST1_ASCSU
- ProteinGlutathione S-transferase 1
- GeneGST1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids206 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can also function as a GSH peroxidase.
Catalytic activity
- glutathione + RX = a halide anion + an S-substituted glutathione + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 8 | glutathione (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 39 | glutathione (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 43 | glutathione (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 49-51 | glutathione (UniProtKB | ChEBI) | ||||
Sequence: GQL | ||||||
Binding site | 63-64 | glutathione (UniProtKB | ChEBI) | ||||
Sequence: QS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | brush border | |
Cellular Component | cytoplasm | |
Molecular Function | glutathione peroxidase activity | |
Molecular Function | glutathione transferase activity | |
Biological Process | cellular oxidant detoxification | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione S-transferase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Ascaridoidea > Ascarididae > Ascaris
Accessions
- Primary accessionP46436
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Protein family/group databases
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000185922 | 2-206 | Glutathione S-transferase 1 | |||
Sequence: PQYKLTYFDIRGLGEGARLIFHQAGVKFEDNRLKREDWPALKPKTPFGQLPLLEVDGEVLAQSAAIYRYLGRQFGLAGKTPMEEAQVDSIFDQFKDFMAELRPCFRVLAGFEEGDKEKVLKEVAVPARDKHLPLLEKFLAKSGSEYMVGKSVTWADLVITDSLASWESLIPDFLSGHLQLKKYIEHVRELPNIKKWIAERPKTPY |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-79 | GST N-terminal | ||||
Sequence: PQYKLTYFDIRGLGEGARLIFHQAGVKFEDNRLKREDWPALKPKTPFGQLPLLEVDGEVLAQSAAIYRYLGRQFGLAG | ||||||
Domain | 81-206 | GST C-terminal | ||||
Sequence: TPMEEAQVDSIFDQFKDFMAELRPCFRVLAGFEEGDKEKVLKEVAVPARDKHLPLLEKFLAKSGSEYMVGKSVTWADLVITDSLASWESLIPDFLSGHLQLKKYIEHVRELPNIKKWIAERPKTPY |
Sequence similarities
Belongs to the GST superfamily. Sigma family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length206
- Mass (Da)23,585
- Last updated2007-01-23 v3
- ChecksumB8366238A63DF399
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X75502 EMBL· GenBank· DDBJ | CAA53218.1 EMBL· GenBank· DDBJ | mRNA | ||
Y10613 EMBL· GenBank· DDBJ | CAA71620.1 EMBL· GenBank· DDBJ | Genomic DNA |