P46436 · GST1_ASCSU

Function

function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can also function as a GSH peroxidase.

Catalytic activity

Features

Showing features for binding site.

120620406080100120140160180200
TypeIDPosition(s)Description
Binding site8glutathione (UniProtKB | ChEBI)
Binding site39glutathione (UniProtKB | ChEBI)
Binding site43glutathione (UniProtKB | ChEBI)
Binding site49-51glutathione (UniProtKB | ChEBI)
Binding site63-64glutathione (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentbrush border
Cellular Componentcytoplasm
Molecular Functionglutathione peroxidase activity
Molecular Functionglutathione transferase activity
Biological Processcellular oxidant detoxification
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione S-transferase 1
  • EC number
  • Alternative names
    • GST class-sigma

Gene names

    • Name
      GST1

Organism names

Accessions

  • Primary accession
    P46436

Subcellular Location

Phenotypes & Variants

Protein family/group databases

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001859222-206Glutathione S-transferase 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-79GST N-terminal
Domain81-206GST C-terminal

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    206
  • Mass (Da)
    23,585
  • Last updated
    2007-01-23 v3
  • Checksum
    B8366238A63DF399
MPQYKLTYFDIRGLGEGARLIFHQAGVKFEDNRLKREDWPALKPKTPFGQLPLLEVDGEVLAQSAAIYRYLGRQFGLAGKTPMEEAQVDSIFDQFKDFMAELRPCFRVLAGFEEGDKEKVLKEVAVPARDKHLPLLEKFLAKSGSEYMVGKSVTWADLVITDSLASWESLIPDFLSGHLQLKKYIEHVRELPNIKKWIAERPKTPY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X75502
EMBL· GenBank· DDBJ
CAA53218.1
EMBL· GenBank· DDBJ
mRNA
Y10613
EMBL· GenBank· DDBJ
CAA71620.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp